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Multicomponent reactions of ammonium thiocyanate, acyl chlorides, alkyl bromides, and enaminones: A facile one-pot synthesis of thiophenes

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Abstract

An efficient synthesis of thiophene derivatives is described via one-pot reaction between ammonium thiocyanate, acyl chlorides, α-halocarbonyls, and enaminones under solvent-free conditions at 65 °C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.

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Correspondence to Zinatossadat Hossaini.

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Hossaini, Z., Rostami-Charati, F., Soltani, S. et al. Multicomponent reactions of ammonium thiocyanate, acyl chlorides, alkyl bromides, and enaminones: A facile one-pot synthesis of thiophenes. Mol Divers 15, 911–916 (2011). https://doi.org/10.1007/s11030-011-9322-5

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  • DOI: https://doi.org/10.1007/s11030-011-9322-5

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