Abstract
A palladium-catalyzed selective synthesis of cis- or trans-chloro-substituted-\(\alpha \)-methylene-\(\gamma \)-butyrolactones from single substrate (propiolic acid) has been realized by controlling cis- or trans-chloropalladation. This method is highly effective for building C–Cl, C–O, and C–C bonds into a one-pot procedure because of its good atom and step efficiency.
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Acknowledgments
We acknowledge Bo Liu and Tongxiang Cao for their assistance in preparation of intermediates. This research is supported financially by the joint grant of National Natural Science Foundation of China (NSFC) and National Institute of Health (NIH) of USA (No. 81161120402) and the National 863 Program of China, No. 2012AA020303.
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Dong, Y., Guo, X., Yu, Y. et al. Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-\(\alpha \)-methylene-\(\gamma \)-butyrolactone by possibly controlling cis- and trans-chloropalladation. Mol Divers 17, 1–7 (2013). https://doi.org/10.1007/s11030-012-9419-5
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DOI: https://doi.org/10.1007/s11030-012-9419-5