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One-step synthesis of azole- and benzazole-based sulfonamides in aqueous media

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Abstract

Several benzazoles (benzoxazoles, benzothiazoles, and benzimidazoles) and azoles (1\(H\)-1,2,4-triazole-5(4\(H\))-thiones and 1,2,4-oxadiazoles) bearing a sulfonamide moiety were efficiently prepared via the reactions of dimethyl (arylsulfonyl) dithioimidocarbonate derivatives and their 2-aminobenzene precursors, thiosemicarbazides, and amidoximes, respectively, in the presence of \(\hbox {K}_{2}\hbox {CO}_{3}\) as a base in aqueous ethanol (25 %) as a green media in moderate to excellent yields.

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Acknowledgments

We warmly thank the University of Isfahan research council for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, University of Isfahan, 81746-73441, Isfahan, Iran

    Hassan Zali-Boeini, Zhaleh Najafi, Bahareh Abtahi & Hajar Golshadi Ghaleshahi

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  1. Hassan Zali-Boeini
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  2. Zhaleh Najafi
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  3. Bahareh Abtahi
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Correspondence to Hassan Zali-Boeini.

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Zali-Boeini, H., Najafi, Z., Abtahi, B. et al. One-step synthesis of azole- and benzazole-based sulfonamides in aqueous media. Mol Divers 19, 283–292 (2015). https://doi.org/10.1007/s11030-015-9567-5

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