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Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s

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Abstract

An ethylene glycol promoted catalyst-free practically efficient and sustainable approach has been developed for the synthesis of several benzylidene-bis-(4-hydroxycoumarin)s and 4,\(4^{\prime }\)-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s by the pseudo three-component reaction of an aldehyde with 4-hydroxycoumarin and 3-methyl-1-phenylpyrazol-5-one, respectively. Inexpensive, non-toxic, and easily available ethylene glycol used as the reaction solvent and promoter renders an efficient protocol in terms of catalyst-free reaction conditions, short reaction time, high yield, practical utility, and green approach.

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Fig. 1
Scheme 1
Scheme 2

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Acknowledgments

Authors are thankful to the Director, SAIF, Chandigarh for providing spectral data.

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Authors and Affiliations

  1. Department of Chemistry, Deogiri College, Station Road, Aurangabad, MS, 431 005, India

    Sushama S. Kauthale, Kavita M. Jadhav & Rajendra P. Pawar

  2. Department of Chemistry, Shri Muktanand College, Gangapur, MS, 431 109, India

    Sunil U. Tekale

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  1. Sushama S. Kauthale
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  2. Sunil U. Tekale
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  3. Kavita M. Jadhav
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  4. Rajendra P. Pawar
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Correspondence to Rajendra P. Pawar.

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Kauthale, S.S., Tekale, S.U., Jadhav, K.M. et al. Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s. Mol Divers 20, 763–770 (2016). https://doi.org/10.1007/s11030-016-9673-z

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  • DOI: https://doi.org/10.1007/s11030-016-9673-z

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