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Association of ADIPOQ gene with obesity and adiponectin levels in Malaysian Malays

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Abstract

Studies have shown that single-nucleotide polymorphisms (SNPs) on the ADIPOQ gene have been linked with obesity and with adiponectin levels in various populations. Here, we aimed to investigate the association of ADIPOQ rs17366568 and rs3774261 SNPs with obesity and with adiponectin levels in Malaysian Malays. Obesity parameters and adiponectin levels were measured in 574 subjects. Genotyping was performed using real-time polymerase chain reaction and Sequenom MassARRAY. A significant genotypic association was observed between ADIPOQ rs17366568 and obesity. The frequencies of AG and AA genotypes were significantly higher in the obese group (11 %) than in the non-obese group (5 %) (P = 0.024). The odds of A alleles occurring among the obese group were twice those among the non-obese group (odds ratio 2.15; 95 % confidence interval 1.13–4.09). However, no significant association was found between allelic frequencies of ADIPOQ rs17366568 and obesity after Bonferroni correction (P > 0.025) or between ADIPOQ rs3774261 and obesity both at allelic and genotypic levels. ADIPOQ SNPs were not significantly associated with log-adiponectin levels. GA, GG, and AG haplotypes of the ADIPOQ gene were not associated with obesity. We confirmed the previously reported association of ADIPOQ rs17366568 with the risk of obesity. ADIPOQ SNPs are not important modulators of adiponectin levels in this population.

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Acknowledgments

This study was supported by research grants RG075-09HTM from the University of Malaya and HIR-MOHE E000049-20001. We would like to acknowledge the assistance of Ms. Devi Peramalah, the Wellness Program team, Narong Jaturas, Thanet Sornda, the medical students who assisted in data collection, and all of the participants in this research. We would also like to acknowledge Barbara Every, a board-certified Editor in the Life Sciences (ELS) for editing the manuscript.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia

    Yamunah Devi Apalasamy & Zahurin Mohamed

  2. Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia

    Sanjay Rampal, Foong Ming Moy & Awang Bulgiba

  3. Department of Mathematics and Statistics, La Trobe University, Bundoora, VIC, 3086, Australia

    Agus Salim

Authors
  1. Yamunah Devi Apalasamy
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  2. Sanjay Rampal
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  3. Agus Salim
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  4. Foong Ming Moy
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  5. Awang Bulgiba
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  6. Zahurin Mohamed
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Correspondence to Yamunah Devi Apalasamy.

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Apalasamy, Y.D., Rampal, S., Salim, A. et al. Association of ADIPOQ gene with obesity and adiponectin levels in Malaysian Malays. Mol Biol Rep 41, 2917–2921 (2014). https://doi.org/10.1007/s11033-014-3147-0

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  • DOI: https://doi.org/10.1007/s11033-014-3147-0

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