Abstract
We report that silicon nanoparticles (SiNPs) with typical sizes from 5 to 50 nm prepared by grinding of porous silicon can act as efficient scavengers of human immunodeficiency virus (HIV) and respiratory syncytial virus (RSV). In vitro studies have revealed a strong suppression of the viral activity in the presence of SiNPs with concentration above 0.1 and 0.01 mg/mL for HIV and RSV, respectively. The observed effect is explained by binding of the virions with SiNPs that is supposed to be universal for different enveloped viruses. Because of the cytotoxic concentration of SiNPs is of the order of 1 mg/mL, SiNPs can be proposed for applications in new harmless methods of antiviral treatment.
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Acknowledgments
The authors thank Mr. D. Petrov and Dr. A. Gylyazova for their assistance in SEM measurements and cell cytotoxicity evaluation, respectively. The work was partially supported by RFBR (Project No. 12-02-31266 mol_a) and the Russian Ministry of Education and Science (Project No. 8737).
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Osminkina, L.A., Timoshenko, V.Y., Shilovsky, I.P. et al. Porous silicon nanoparticles as scavengers of hazardous viruses. J Nanopart Res 16, 2430 (2014). https://doi.org/10.1007/s11051-014-2430-2
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DOI: https://doi.org/10.1007/s11051-014-2430-2