Abstract
All variables affecting the morphology of mesoporous silica nanoparticles (MSN) should be carefully analyzed in order to truly tailored design their mesoporous structure according to their final use. Although complete control on MCM-41 synthesis has been already claimed, reproducibility and repeatability of results remain a big issue due to the lack of information reported in literature. Stirring rate, reaction volume, and system configuration (i.e., opened or closed reactor) are three variables that are usually omitted, making the comparison of product characteristics difficult. Specifically, the rate of solvent evaporation is seldom disclosed, and its influence has not been previously analyzed. These variables were systematically studied in this work, and they were proven to have a fundamental impact on final particle morphology. Hence, a high degree of circularity (C = 0.97) and monodispersed particle size distributions were only achieved when a stirring speed of 500 rpm and a reaction scale of 500 mL were used in a partially opened system, for a 2 h reaction at 80 °C. Well-shaped spherical mesoporous silica nanoparticles with a diameter of 95 nm, a pore size of 2.8 nm, and a total surface area of 954 m2 g−1 were obtained. Final characteristics made this product suitable to be used in biomedicine and nanopharmaceutics, especially for the design of drug delivery systems.
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Acknowledgements
José L. Gómez Ribelles acknowledges the support of the Ministerio de Economía y Competitividad, MINECO (research number MAT2016-76039-C4-1-R). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work was also supported by COLCIENCIAS (Departamento Administrativo de Ciencia Tecnología e Innovación, Convocatoria 567 Doctorados Nacionales) and Universidad Nacional de Colombia (grant number DIB 201010021438).
The authors would like to thank Professor Ramón Martínez Máñez, Scientific Director of CIBER’s Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and his research group at the Laboratory of Nanomedicine, from the Center for Molecular Recognition and Technological Development (UPV-IQMA), for their support and willingness. The authors acknowledge the assistance from the Microscopy Service at the UPV where all micrographs were taken.
Funding
This study was funded partially by Departamento Administrativo de Ciencia Tecnología e Innovación–COLCIENCIAS (recipient, Angela A. Beltrán-Osuna); Ministerio de Economía y Competitividad, MINECO, research number MAT2016-76039-C4-1-R (Recipient, José L. Gómez-Ribelles); and Universidad Nacional de Colombia, grant number DIB 201010021438 (Recipient, Jairo E. Perilla).
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Beltrán-Osuna, Á.A., Gómez Ribelles, J.L. & Perilla, J.E. A study of some fundamental physicochemical variables on the morphology of mesoporous silica nanoparticles MCM-41 type. J Nanopart Res 19, 381 (2017). https://doi.org/10.1007/s11051-017-4077-2
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DOI: https://doi.org/10.1007/s11051-017-4077-2