The actions of chronic i.p. administration of the proinflammatory cytokine interleukin-1β (IL-1β) on exploratory behavior and spatial memory were studied in rats. IL-1β was given at the weakly pyrogenic dose of 0.5 μg/kg daily for 14 days (starting seven days before and continuing through seven days of behavioral testing). Behavior was analyzed 23.5 h after sequential injections of cytokine. A battery of tests was used, including the open field test (on three sequential days), exploration of novel objects, and the Morris water maze. Experimental animals showed a significant decrease in motor activity, a minor increase in anxiety, and suppression of exploratory behavior. Impairments to spatial memory were not seen.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 101, No. 5, pp. 550–558, May, 2015.
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Kalemenev, S.V., Sizov, V.V., Ishchenko, A.M. et al. Effects of Chronic Administration of Low-Dose Interleukin-1β on Exploratory Behavior and Spatial Memory in Rats. Neurosci Behav Physi 46, 903–907 (2016). https://doi.org/10.1007/s11055-016-0330-x
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DOI: https://doi.org/10.1007/s11055-016-0330-x