Two groups of Wistar rats with opposite behavioral strategies – active and passive – were subjected to chronic mild stress. Half of the group of poststress animals received intranasal oxytocin (at a dose of 0.25 IU); their behavior was tested in the Porsolt test and their consumption of a sweet solution was evaluated. Stressed animals with the active behavioral strategy did not respond to oxytocin. Oxytocin partially restored behavior to prestress levels only in animals starting with the passive behavioral strategy.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 103, No. 1, pp. 3–9, January, 2017.
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Vinogradova, E.P., Zhukov, D.A. The Effects of Intranasal Administration of Oxytocin on the Behavior of Rats with Different Behavioral Strategies Subjected to Chronic Mild Stress. Neurosci Behav Physi 48, 333–336 (2018). https://doi.org/10.1007/s11055-018-0566-8
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DOI: https://doi.org/10.1007/s11055-018-0566-8