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Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas

  • Laboratory Investigation - Human/Animal Tissue
  • Published:
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Abstract

Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis are yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients, with prevalence of nuclear HDGF predicting short survival of patients with GBM after surgery. To delineate the mitogenic role of HDGF in gliomagenesis, an adenoviral-expressed HDGF small interfering RNA (Ad-HDGF siRNA) was used to knock down expression of nuclear HDGF. After knocking down nuclear HDGF expression in human GBM cells, cell growth and cell invasion and induction on apoptosis by caspase-3 activation were significantly inhibited. We conclude that HDGF is a mitogenic growth factor in glioma progression and can be a useful prognostic marker for GBM and therapeutic target for clinical management of glioma in the future.

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Acknowledgements

This work was supported in part by grants from the National Science Council (NSC 95-2311-B-214-001; NSC 96-2314-B-075B-007; NSC 98-2314-B-075B-006-MY3), Kaohsiung Veterans General Hospital(VGHKS-98-043; VGHKS-97-A010), and I-Shou University (ISU98-04-05), Taiwan.

Conflict of interest

None of the authors have conflicts of interests.

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Authors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.

    Shu-Shong Hsu, Chih-Hao Chen & Jain-Ching Wu

  2. O’Brien Institute, University of Melbourne, Fitzroy, Australia

    Guei-Sheung Liu & Elsa C. Chan

  3. Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C.

    Ming-Hong Tai

  4. Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.

    Jyh-Seng Wang

  5. Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C.

    Mei-Lang Kung

  6. Department of Biological Science & Technology, I-Shou University, No.242, Sec. 1, Syuecheng Rd, 840, Dashu, Kaohsiung, Taiwan, R.O.C.

    Li-Feng Liu

  7. Department of Electrical Engineering, I-Shou University, Kaohsiung, Taiwan, R.O.C.

    Chih-Hao Chen

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  1. Shu-Shong Hsu
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Correspondence to Li-Feng Liu.

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Hsu, SS., Chen, CH., Liu, GS. et al. Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas. J Neurooncol 107, 101–109 (2012). https://doi.org/10.1007/s11060-011-0733-z

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  • DOI: https://doi.org/10.1007/s11060-011-0733-z

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