Skip to main content
Log in

Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS) was measured by Kaplan–Meier and Cox proportional hazards methods. A total of 28 patients (15 males, 13 females) were treated between 1995 and 2014, with a median age at diagnosis of 26 years (range 5–61). Median follow-up was 62.2 months and 3 patients were lost to follow-up postoperatively. Thirteen patients experienced recurrent/progressive disease and 2-year PFS was 75 % (95 % CI 53–88 %). Two-year PFS was 48 % for MIB-1 labeling >4 % versus 90 % for ≤4 % (HR 5.4, CI 2.2–27.8, p = 0.0026). Nine patients (32 %) had gross total resections (GTR) and 19 (68 %) had subtotal resections (STR). PFS for >80 % resection was 83 versus 67 % for ≤80 % resection (HR 0.67, CI 0.23–2.0, p = 0.47). Three STR patients (16 %) received adjuvant radiation which significantly improved overall PFS (p = 0.049). Estimated 5-year PFS was 67 % for STR with radiotherapy versus 53 % for STR without radiotherapy. Salvage therapy regimens were diverse and resulted in stable disease for 54 % of patients and additional progression for 38 %. Two patients with neuropathology-confirmed atypical neurocytomas died at 4.3 and 113.4 months after initial surgery. For central neurocytomas, MIB-1 labeling index >4 % is predictive of poorer outcome and our data suggest that adjuvant radiotherapy after STR may improve PFS. Most patients requiring salvage therapy will be stabilized and multiple modalities can be effectively utilized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellissier JF, Toga M (1982) Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol (Berl) 56:151–156

    Article  CAS  Google Scholar 

  2. Mozes P, Szanto E, Tiszlavicz L, Barzo P, Cserhati A, Fodor E, Hideghety K (2013) Clinical Course of Central Neurocytoma with Malignant Transformation-An Indication for Craniospinal Irradiation. Pathol Oncol Res POR

  3. Hassoun J, Söylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P (1993) Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol Zurich Switz 3:297–306

    Article  CAS  Google Scholar 

  4. Sharma MC, Deb P, Sharma S, Sarkar C (2006) Neurocytoma: a comprehensive review. Neurosurg Rev 29:270–285

  5. Schmidt MH, Gottfried ON, von Koch CS, Chang SM, McDermott MW (2004) Central neurocytoma: a review. J Neurooncol 66:377–384

    Article  PubMed  Google Scholar 

  6. Zhang D, Wen L, Henning TD, Feng X-Y, Zhang Y-L, Zou L-G, Zhang Z-G (2006) Central neurocytoma: clinical, pathological and neuroradiological findings. Clin Radiol 61:348–357

    Article  CAS  PubMed  Google Scholar 

  7. Smith AB, Smirniotopoulos JG, Horkanyne-Szakaly I (2013) From the Radiologic Pathology Archives: Intraventricular Neoplasms: Radiologic-Pathologic Correlation. RadioGraphics 33:21–43

    Article  PubMed  Google Scholar 

  8. Wang M, Jia D, Shen J, Zhang J, Li G (2013) Clinical and imaging features of central neurocytomas. J Clin Neurosci Off J Neurosurg Soc Australas 20:679–685

    Google Scholar 

  9. Christov C, Adle-Biassette H, Le Guerinel C (1999) Recurrent central neurocytoma with marked increase in MIB-1 labelling index. Br J Neurosurg 13:496–499

    Article  CAS  PubMed  Google Scholar 

  10. Garcia RM, Ivan ME, Oh T, Barani I, Parsa AT (2014) Intraventricular neurocytomas: a systematic review of stereotactic radiosurgery and fractionated conventional radiotherapy for residual or recurrent tumors. Clin Neurol Neurosurg 117:55–64

    Article  PubMed  Google Scholar 

  11. Söylemezoglu F, Scheithauer BW, Esteve J, Kleihues P (1997) Atypical central neurocytoma. J Neuropathol Exp Neurol 56:551–556

    Article  PubMed  Google Scholar 

  12. Sharma MC, Rathore A, Karak AK, Sarkar C (1998) A study of proliferative markers in central neurocytoma. Pathology (Phila) 30:355–359

    CAS  Google Scholar 

  13. Mackenzie IR (1999) Central neurocytoma: histologic atypia, proliferation potential, and clinical outcome. Cancer 85:1606–1610

    Article  CAS  PubMed  Google Scholar 

  14. Genc A, Bozkurt SU, Karabagli P, Seker A, Bayri Y, Konya D, Kilic T (2011) Gamma knife radiosurgery for cranial neurocytomas. J Neurooncol 105:647–657

    Article  PubMed  Google Scholar 

  15. Rades D, Schild SE, Fehlauer F (2004) Prognostic value of the MIB-1 labeling index for central neurocytomas. Neurology 62:987–989

    Article  PubMed  Google Scholar 

  16. Kaur G, Kane AJ, Sughrue ME, Oh M, Safaee M, Sun M, Tihan T, McDermott MW, Berger MS, Parsa AT (2013) MIB-1 labeling index predicts recurrence in intraventricular central neurocytomas. J Clin Neurosci Off J Neurosurg Soc Australas 20:89–93

    Google Scholar 

  17. Leenstra JL, Rodriguez FJ, Frechette CM et al (2007) Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 67:1145–1154

    Article  PubMed  Google Scholar 

  18. Hallock A, Hamilton B, Ang LC, Tay KY, Meygesi JF, Fisher BJ, Watling CJ, Macdonald DR, Bauman GS (2011) Neurocytomas: long-term experience of a single institution. Neuro-Oncol 13:943–949

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Chen H, Zhou R, Liu J, Tang J (2012) Central neurocytoma. J Clin Neurosci Off J Neurosurg Soc Australas 19:849–853

    Google Scholar 

  20. Qian H, Lin S, Zhang M, Cao Y (2012) Surgical management of intraventricular central neurocytoma: 92 cases. Acta Neurochir (Wien) 154:1951–1960

    Article  Google Scholar 

  21. Kim JW, Kim DG, Kim IK et al (2013) Central neurocytoma: long-term outcomes of multimodal treatments and management strategies based on 30 years’ experience in a single institute. Neurosurgery 72:407–413

  22. Nakagawa K, Aoki Y, Sakata K, Sasaki Y, Matsutani M, Akanuma A (1993) Radiation therapy of well-differentiated neuroblastoma and central neurocytoma. Cancer 72:1350–1355

    Article  CAS  PubMed  Google Scholar 

  23. Schild SE, Scheithauer BW, Haddock MG, Schiff D, Burger PC, Wong WW, Lyons MK (1997) Central neurocytomas. Cancer 79:790–795

    Article  CAS  PubMed  Google Scholar 

  24. Kim DG, Paek SH, Kim IH, Chi JG, Jung HW, Han DH, Choi KS, Cho BK (1997) Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 79:1995–2002

    Article  CAS  PubMed  Google Scholar 

  25. Kulkarni V, Rajshekhar V, Haran RP, Chandi SM (2002) Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy. Br J Neurosurg 16:126–132

    Article  CAS  PubMed  Google Scholar 

  26. Anderson RC, Elder JB, Parsa AT, Issacson SR, Sisti MB (2001) Radiosurgery for the treatment of recurrent central neurocytomas. Neurosurgery 48:1231–1237

  27. Hara M, Aoyagi M, Yamamoto M, Maehara T, Takada Y, Nojiri T, Ohno K (2003) Rapid shrinkage of remnant central neurocytoma after gamma knife radiosurgery: a case report. J Neurooncol 62:269–273

    Article  PubMed  Google Scholar 

  28. Brandes AA, Amistà P, Gardiman M, Volpin L, Danieli D, Guglielmi B, Carollo C, Pinna G, Turazzi S, Monfardini S (2000) Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer 88:169–174

    Article  CAS  PubMed  Google Scholar 

  29. Rades D, Schild SE (2006) Treatment recommendations for the various subgroups of neurocytomas. J Neurooncol 77:305–309

    Article  PubMed  Google Scholar 

  30. Rades D, Fehlauer F, Schild SE (2004) Treatment of atypical neurocytomas. Cancer 100:814–817

    Article  PubMed  Google Scholar 

  31. Bertalanffy A, Roessler K, Koperek O, Gelpi E, Prayer D, Knosp E (2005) Recurrent central neurocytomas. Cancer 104:135–142

    Article  PubMed  Google Scholar 

  32. Vasiljevic A, François P, Loundou A, Fèvre-Montange M, Jouvet A, Roche P-H, Figarella-Branger D (2012) Prognostic factors in central neurocytomas: a multicenter study of 71 cases. Am J Surg Pathol 36:220–227

    Article  PubMed  Google Scholar 

  33. Chen Y-D, Li W-B, Feng J, Qiu X-G (2014) Long-term outcomes of adjuvant radiotherapy after surgical resection of central neurocytoma. Radiat Oncol Lond Engl 9:242

    Article  Google Scholar 

  34. Choudhari KA, Kaliaperumal C, Jain A, Sarkar C, Soo MYS, Rades D, Singh J (2009) Central neurocytoma: a multi-disciplinary review. Br J Neurosurg 23:585–595

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported in part by the NIH Brain Tumor SPORE grant P50 CA097257 (DHK), Nancy and Stephen Grand Philanthropic Fund (DHK), and The V Foundation (DHK) as well as by the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number TL1 TR000144 (BSI).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daphne A. Haas-Kogan.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Imber, B.S., Braunstein, S.E., Wu, F.Y. et al. Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience. J Neurooncol 126, 193–200 (2016). https://doi.org/10.1007/s11060-015-1959-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-015-1959-y

Keywords

Navigation