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Prognosis and treatment outcomes of central neurocytomas: clinical interrogation based on a single center experience

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Abstract

Introduction

Central neurocytoma (CN) is a very rare neuronal neoplasm. The clinical implications of the potential prognostic factors for these lesions, including tumor atypia, have therefore not been clarified.

Methods

Forty CN patients were enrolled and reclassified as typical or atypical in accordance with an MIB-1 labeling index (LI) of above and below 2%.

Results

We classified our retrospective study cohort as 21 (52.5%) typical and 19 (47.5%) atypical CN cases. No significant differences were found in terms of sex, mean age, mean tumor size or tumor location between these groups. Recurrences occurred in 2 (9.5%) typical and 6 (33.3%) atypical cases. The typical CN 2-,3- and 5-year PFS rates were 100%, 100%, 92.3%, and those for the atypical group were 93.8%, 78.1%, 65.1%, respectively (p = 0.02). The PFS rates did not statistically differ by treatment modality (gross total resection alone, subtotal resection (STR) alone and STR plus radiation therapy (RT) or radiosurgery (RS)) either in the whole cohort (p = 0.75) or in the typical CN and atypical CN subgroups (p = 0.45 and 0.98, respectively). An atypical histology was the only prognostic indicator of recurrence by univariate analysis (hazard ratio: 5.40, p = 0.04).

Conclusions

An atypical lesion (MIB-LI > 2%) is an important prognostic indicator in CN. The clinical implications of the extent of resection for CN patients are still debatable. The use of STR plus RT or RS may be a viable treatment strategy for CN but different therapeutic and follow-up approaches for atypical CN will be needed.

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Acknowledgements

We thank the referring physicians, our institutional neuroradiologists and pathologists.

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Authors and Affiliations

  1. Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea

    Joonho Byun, Seok Ho Hong, Sae Min Kwon, Young Hyun Cho, Jeong Hoon Kim & Chang Jin Kim

  2. Department of Radiology, Konyang University Hospital, University of Konyang College of Medicine, Daejeon, South Korea

    Min Jae Yoon

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  1. Joonho Byun
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  2. Seok Ho Hong
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  3. Min Jae Yoon
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  4. Sae Min Kwon
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  5. Young Hyun Cho
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  7. Chang Jin Kim
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Correspondence to Seok Ho Hong.

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The authors declare no competing interests in relation to this study.

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Byun, J., Hong, S.H., Yoon, M.J. et al. Prognosis and treatment outcomes of central neurocytomas: clinical interrogation based on a single center experience. J Neurooncol 140, 669–677 (2018). https://doi.org/10.1007/s11060-018-2997-z

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  • DOI: https://doi.org/10.1007/s11060-018-2997-z

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