Abstract
Introduction
Central neurocytoma (CN) and extraventricular neurocytoma (EVN) are rare intracranial tumors. There is a paucity of studies reporting the population-based incidence of these tumors. We used the Central Brain Tumor Registry of the United States (CBTRUS), which contains the largest aggregation of population-based data on the incidence of primary central nervous system tumors in the United States to describe these tumors.
Methods
The CBTRUS database, provided by CDC representing approximately 100% of the US population, was queried using the following search criteria: diagnosis years 2006–2014, ICD-0-3 histology codes (9506/0: central neurocytoma, benign; 9506/1: central neurocytoma, uncertain). Annual age-adjusted incidence rates are presented per 100,000 population. Incidence was estimated by age, gender, race, and ethnicity.
Results
The combined overall annual incidence rate of CN and EVN was 0.032 [0.030–0.034]. The incidence rates were 0.022 [0.021–0.024] and 0.009 [0.008–0.010] for CN and EVN, respectively. The most frequently documented locations for EVN were frontal lobe and cerebellum, followed by temporal lobe. Peak incidence was found in the 20–34 years range for both CN and EVN. The incidence rate was slightly lower in males compared to females for CN and identical for EVN. The overall incidence rate of CN and EVN combined was lower in Blacks 0.026 [0.021–0.032] and Hispanic Whites 0.020 [0.016–0.025] compared to Non-Hispanic Whites 0.035 [0.033–0.038].
Conclusion
CN and EVN are rare tumors with a peak incidence in the 20–34 years age group. This study represents the largest population-based epidemiological study on CN and EVN in the US.
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Acknowledgements
We are truly thankful to our valued reviewer, Reda Wilson MPH, who volunteered her time and knowledge to review and comment upon this manuscript to ensure the quality and accuracy of this study.
Funding
Funding for CBTRUS was provided by the Centers for Disease Control and Prevention (CDC) under Contract No. 2016-M-9030, the American Brain Tumor Association, The Sontag Foundation, Novocure, Abbvie, and the National Cancer Institute (NCI) under Contract No. HHSN261201800176P, the Musella Foundation, as well as private and in kind donations. Contents are solely the responsibility of the authors and do not necessarily reflect the official views of the CDC and the NCI.
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Tish, S., Habboub, G., Jones, J. et al. The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014. J Neurooncol 143, 123–127 (2019). https://doi.org/10.1007/s11060-019-03144-9
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DOI: https://doi.org/10.1007/s11060-019-03144-9