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Synthesis and Antimycobacterial Activity of 5-(Arylmethylene)Hexahydropyrimidine-2,4,6-Triones

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A series of 5-(arylmethylene)hexahydropyrimidine-2,4,6-triones were synthesized. Their antimycobacterial activity and acute daily toxicity with respect to M. lufu were investigated.

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Acknowledgments

The work was supported financially by the program “Development of innovative infrastructure at Russian Higher Educational Institutions” (Grant No. 13.637.31.0038) and used scientific equipment of the CCU “Biotechnology for creating original drug substances.”

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Authors and Affiliations

  1. Leprosy Research Institute, RF Ministry of Health, Astrakhan, 414057, Russia

    S. A. Luzhnova & N. M. Gabitova

  2. Astrakhan State University, Astrakhan, 414956, Russia

    A. G. Tyrkov

Authors
  1. S. A. Luzhnova
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  2. A. G. Tyrkov
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  3. N. M. Gabitova
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  4. E. A. Yurtaeva
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 12, pp. 12 – 14, December, 2015.

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Luzhnova, S.A., Tyrkov, A.G., Gabitova, N.M. et al. Synthesis and Antimycobacterial Activity of 5-(Arylmethylene)Hexahydropyrimidine-2,4,6-Triones. Pharm Chem J 49, 810–812 (2016). https://doi.org/10.1007/s11094-016-1376-3

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  • DOI: https://doi.org/10.1007/s11094-016-1376-3

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