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Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity

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Pharmaceutical Chemistry Journal Aims and scope

5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human flu viruses A/H3N2 and A/H1N1pdm09.

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Acknowledgments

The work was performed on State Task Topic “Synthesis of biologically active heterocyclic and diterpenoid compounds” No. AAAA-A17 – 117011910025. Spectral and quantum-chemical parts used equipment at the Khimiya CUC, UfIC, RAS.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Scientific Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054, Russia

    I. B. Chernikova, S. L. Khursan & M. S. Yunusov

  2. Research Institute of Influenza, Ministry of Healthcare of the Russian Federation, 15/17 Prof. Popova St., St. Petersburg, 197376, Russia

    M. Yu. Eropkin

Authors
  1. I. B. Chernikova
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  2. S. L. Khursan
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  3. M. Yu. Eropkin
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  4. M. S. Yunusov
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Corresponding author

Correspondence to I. B. Chernikova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 2, pp. 16 – 20, February, 2019.

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Chernikova, I.B., Khursan, S.L., Eropkin, M.Y. et al. Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity. Pharm Chem J 53, 108–112 (2019). https://doi.org/10.1007/s11094-019-01962-9

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  • DOI: https://doi.org/10.1007/s11094-019-01962-9

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