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Morita Baylis Hillman Adduct Serves as Ligand in the Synthesis of Transition Metal Complexes Exhibiting Antibacterial Activity

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Pharmaceutical Chemistry Journal Aims and scope

In the present work, Morita—Baylis–Hillman (MBH) adduct ligand 3 was prepared under MBH reaction conditions. The compound was purified by chromatographic techniques and structurally confirmed by methods of spectral analysis. Ligand 3 was separately treated with various salts of transition metals (Mn, Cu, Ce and Lu) under basic conditions with and reflux and stirring. This treatment yielded complexes 5–8, the molecular and structural formulas of which were established by spectral and elemental analysis. Then, complexes 5–8 were checked for their antibacterial potential against four strains (E. coli, S. aureus, P. mirabilis, and P. aeruginosa). Almost all compounds exhibited good activity except Mn and Lu complexes which were inactive against S. aureus and P. aeruginosa, respectively. Cerium complex showed moderate antibacterial activity against all selected strains. Among all, Cu complex was fund to be the most active one against the selected bacterial strains. This study demonstrated the first example of using the MBH adduct as ligand for the formation of complexes.

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ACKNOWLEDGMENTS

The authors are thankful to MIU AJK for providing infrastructure and also thankful to PCSIR-Peshawar, Pakistan, for support in carrying out elemental analysis, spectral analysis and bioactivity studies.

CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Chemistry, Mohi-ud-Din Islamic University, NS, AJ&K, Islamabad, Pakistan

    Shazia Ishfaq, Taj Ur Rahman & Sadia Majid

  2. Department of Chemistry, FBS, BUITEMS, Takatu Campus, Quetta, 87300, Pakistan

    Hamid Ullah, Mujtaba Ellahi & Noornama Panezai

  3. Department of Physics, FBS, BUITEMS, Takatu Campus, Quetta, 87300, Pakistan

    Nisar Ahmad

  4. Institute of Chemical Sciences, Gomal University, KPK, D. I. Khan, Pakistan

    Syed Badshah

  5. PCSIR Laboratories Complex, Peshawar, Pakistan

    Muhammad Akram

  6. Department of Chemistry, University of Karachi, Karachi, Pakistan

    Shazia Ishfaq

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  1. Shazia Ishfaq
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  2. Hamid Ullah
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Correspondence to Hamid Ullah.

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Ishfaq, S., Ullah, H., Rahman, T.U. et al. Morita Baylis Hillman Adduct Serves as Ligand in the Synthesis of Transition Metal Complexes Exhibiting Antibacterial Activity. Pharm Chem J 56, 906–912 (2022). https://doi.org/10.1007/s11094-022-02725-9

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  • DOI: https://doi.org/10.1007/s11094-022-02725-9

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