Polymer complexes of the homopolymer of 2-acrylamido-2-methylpropanesulfonic acid containing 18.9 – 35.3 wt% of the antituberculosis antibiotic rifampicin were synthesized. The obtained complexes were shown to be stable in EtOH using liquid chromatography. The cytotoxicity of the polymer complexes was found to be 2.4 – 2.8 times less than that of the starting antibiotic while the high antituberculosis activity of rifampicin was retained.
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Acknowledgments
We thank Prof. V. V. Tets for participating in the work. The work was performed in the framework of a State Task, Reg. No. NIOKTR AAAA-A20-120022090044-2.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 8, pp. 17 – 20, August, 2022.
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Solovskii, M.V., Borisenko, M.S., Smirnova, M.Y. et al. Polymer Complexes of Rifampicin Antibiotic Based on poly(2-acrylamido-2-methylpropanesulfonic Acid). Pharm Chem J 56, 1041–1044 (2022). https://doi.org/10.1007/s11094-022-02749-1
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DOI: https://doi.org/10.1007/s11094-022-02749-1