Skip to main content
SpringerLink
Log in

Biodistribution of 177Lu-DOTA-PSMA in Mice with Prostate Carcinoma 22Rv1

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer and is a well-studied target for therapy of this pathology with PSMA-specific radioligands. The aim of this work was to study the biodistribution of the domestic radiopharmaceutical 177Lu-DOTA-PSMA in BALB/c nu/nu (nude) mice with subcutaneously transplanted human prostate carcinoma 22Rv1. 177Lu-DOTA-PSMA was administered intravenously (0.30 MBq/mouse). Uptake of 177Lu-DOTA-PSMA in organs and tissues was calculated in percent of the injected dose. It was shown that the tumor concentration of 177Lu-DOTA-PSMA decreased from 2.46 ± 0.15%/g to 0.020 ± 0.007%/g within 120 h. The highest concentration of 177Lu-DOTA-PSMA (up to 14.578 ± 1.151%/g) was registered in the kidneys. Rapid elimination of 177Lu-DOTA-PSMA from other organs was also observed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

References

  1. Global Cancer Observatory; https: // gco.iarc.fr (accessed Sept. 16, 2022).

  2. A. D. Kaprin, V. V. Starinskii, and A. O. Shakhzadova (eds.), Status of Oncological Assistance to the Russian Population in 2020, MNIOI im. P. A. Gertsena, Filial of FGBU NMITs Radiologii, Ministry of Health of Russia, Moscow (2021), p. 16.

  3. M. Czerwinska, A. Bilewicz, M. Kruszewski, et al., Molecules, 25(7), 1743 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Z. H. Awang, M. Essler, and H. Ahmadzadehfar, Radiat. Oncol., 13(1), 98 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. A. P. Kozikowski, F. Nan, P. Conti, et al., J. Med. Chem., 44(3), 298 – 301 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. S. Brunello, N. Salvarese, D. Carpanese, et al., Molecules, 27(9), 2617 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. E. R. Nemtsova, A. A. Pankratov, N. B. Morozova, et al., Radiats. Biol. Radioekol., 62(3), 250 – 263 (2022).

    Google Scholar 

  8. K. E. Seiter, R. Seifert, K. Kessel, et al., Cancers (Basel), 13(15), 3715 (2021).

    Article  Google Scholar 

  9. O. Sartor, J. de Bono, K. N. Chi, et al., N. Engl. J. Med., 385, 1091 – 1103 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. S. J. Keam, Mol. Diagn. Ther., 26(4), 467 – 475 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. O. P. Vlasova, V. M. Petriev, V. V. Krylov, et al., Med. Fiz., No. 1 (93), 20 – 21 (2022).

  12. R. A. Besyadovskii, K. V. Ivanov, and A. K. Kozyura, Reference Guide for Radiobiologists [in Russian], Atomizdat, Moscow (1978), pp. 90 – 91.

    Google Scholar 

  13. Guideline for Staff of NMITs Radiologii of the Ministry of Health of Russia Working with Laboratory Animals in Preclinical Studies [in Russian], Moscow (2020).

  14. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes; https://rm.coe.int/168007a6a8 (accessed Sept. 2, 2022).

  15. M. Benesova, M. Schafer, U. Bauder-Wust, et al., J. Nucl. Med., 56(6), 914 – 920 (2015).

    Article  CAS  PubMed  Google Scholar 

  16. M. Weineisen, M. Schottelius, J. Simecek, et al., J. Nucl. Med., 56(8), 1169 – 1176 (2015).

    Article  CAS  PubMed  Google Scholar 

  17. M. Staniszewska, P. F. Costa, M. Eiber, et al., Int. J. Mol. Sci., 22(14), 7431 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. C. E. Dumelin, S. Trussel, F. Buller, et al., Angew. Chem., Int. Ed., 47, 3196 – 3201 (2008).

  19. M. Benesova, C. A. Umbricht, R. Schibli, and C. Muller, Mol. Pharm., 15, 934 – 946 (2018).

    Article  CAS  PubMed  Google Scholar 

  20. H. T. Kuo, H. Merkens, Z. Zhang, et al., Mol. Pharmaceutics, 15, 5183 – 5191 (2018).

    Article  CAS  Google Scholar 

  21. J. M. Kelly, A. Amor-Coarasa, S. Ponnala, et al., J. Nucl. Med., 60, 656 – 663 (2019).

    Article  CAS  PubMed  Google Scholar 

  22. H. T. Kuo, K. S. Lin, Z. Zhang, et al., J. Nucl. Med., 62, 521 – 527 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. L. M. Deberle, M. Benesova, C. A. Umbricht, et al., Theranostics, 10, 1678 – 1693 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. V. J. Tschan, F. Borgna, S. D. Busslinger, et al., Eur. J. Nucl. Med. Mol. Imaging, 49(11), 3639 – 3650 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. A. Tsyb Medical Radiological Research Centre, Ministry of Health of Russia, 10 Marshal Zhukov St., Obninsk, 249031, Russia

    V. K. Tishchenko, V. M. Petriev, N. S. Legkodimova, V. V. Krylov & S. A. Ivanov

  2. National Research Nuclear University (MEPhI), 31 Kashirskoe Shosse, Moscow, 115409, Russia

    V. M. Petriev

  3. National Medical Research Radiological Centre, Ministry of Health of Russia, 4 Koroleva St., Obninsk, 240936, Russia

    O. P. Vlasova, P. V. Shegai & A. D. Kaprin

  4. P. A. Hertsen Moscow Oncology Research Institute, Ministry of Health of Russia, 3 2nd Botkinskii Prosp., Moscow, 125284, Russia

    N. B. Morozova & A. A. Pankratov

  5. People’s Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow, 117198, Russia

    S. A. Ivanov & A. D. Kaprin

Authors
  1. V. K. Tishchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. M. Petriev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. P. Vlasova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. S. Legkodimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Krylov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. B. Morozova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. A. Pankratov
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P. V. Shegai
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. S. A. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A. D. Kaprin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. K. Tishchenko.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 2, pp. 12 – 17, February, 2023.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tishchenko, V.K., Petriev, V.M., Vlasova, O.P. et al. Biodistribution of 177Lu-DOTA-PSMA in Mice with Prostate Carcinoma 22Rv1. Pharm Chem J 57, 180–185 (2023). https://doi.org/10.1007/s11094-023-02865-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-023-02865-6

Keywords

Search

Navigation