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Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease

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Abstract

Purpose

Impaired health-related quality of life (HRQoL) is associated with poor health outcomes in chronic obstructive pulmonary disease (COPD). The aim of this study was to determine health utilities in patients with COPD and to identify the variables with the greatest impact.

Methods

This is a pooled analysis of data from 4 observational studies performed in stable COPD patients. Evaluation of patient HRQoL utilities was performed using the Spanish version of the self-administered EuroQoL 5 Dimensions (EQ-5D) questionnaire. EQ-5D utilities were described and compared according to several markers of disease severity.

Results

6198 patients reported a mean (SD) EQ-5D index of 0.67 (0.26). A linear dose response relationship between EQ-5D utility and modified Medical Research Council (mMRC) score, forced expiratory volume in one 1 s (% predicted), COPD hospital admissions in the previous year, self-reported daily walking time, Charlson index, body mass index, obstruction, dyspnoea and exacerbation (BODEx) index, COPD assessment test (CAT), hospital anxiety and depression scale was observed (p for trend < 0.001). In multivariate analysis, patients reporting lower utility values were those with more dyspnoea, more comorbidities, using long-term oxygen therapy, with previous hospitalisations due to a COPD exacerbation and higher (worse) CAT score.

Conclusion

HRQoL measures such as EQ-5D can assist clinicians to understand the impact of respiratory disease on COPD patients.

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Acknowledgements

The FyCEPOC and INSEPOC studies were funded by Laboratorios Esteve S.A (Barcelona, Spain). The NEREA study has been funded by an unrestricted grant from J. Uriach y Compañía S.A. The DEPREPOC study has been funded by Grupo Ferrer (Barcelona, Spain). There was no involvement of funding organisations in the analysis and interpretation of data; in the writing of the report; nor in the decision to submit the article for publication.

Author information

Authors and Affiliations

  1. Department of Pneumology, Hospital Universitari Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035, Barcelona, Spain

    Cristina Esquinas, Maria A. Ramon, Alexa Nuñez, Marc Miravitlles & Miriam Barrecheguren

  2. Public Health, Mental, Maternal and Child Health Nursing Departament, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain

    Cristina Esquinas

  3. Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain

    Maria A. Ramon

  4. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain

    Maria A. Ramon & Marc Miravitlles

  5. Dirección Asistencial Oeste, Centro de Salud Francia, Madrid, Spain

    Jesús Molina

  6. Centro de Salud Lucena, Córdoba, Spain

    José A. Quintano

  7. Primary Health Care Center Son Pisà, IB-Salut, Palma de Mallorca, Spain

    Miguel Roman-Rodríguez

  8. Centro de Salud Fuentes de Ebro, Saragossa, Spain

    Karlos Naberan

  9. Primary Care Centre Via Roma, Barcelona, Spain

    Carl Llor

  10. Psychiatric Service, University of Salamanca Health Care Complex, Institute of Biomedicine of Salamanca, University of Salamanca, Salamanca, Spain

    Carlos Roncero

Authors
  1. Cristina Esquinas
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  2. Maria A. Ramon
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  3. Alexa Nuñez
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  10. Marc Miravitlles
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Corresponding author

Correspondence to Cristina Esquinas.

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Conflict of interest

Marc Miravitlles has received speaker or consulting fees from (in alphabetical order) AstraZeneca, Bial, Boehringer Ingelheim, Chiesi, Cipla, CSL Behring, Laboratorios Esteve, Gebro Pharma, GlaxoSmithKline, Grifols, Menarini, Mereo Biopharma, Novartis, pH Pharma, Rovi, TEVA, Verona Pharma and Zambon, and research grants from GlaxoSmithKline and Grifols, unrelated to this manuscript. The other authors have no conflicts of interest to disclose.

Ethical approval

All procedures performed in this study are in accordance with ethical standards of the Institutional Review Board and with the Declaration of Helsinki. All participants within their respective cohorts gave their informed written consent to participate in the original study, and each study was approved by the Research and Ethics Committee of the Hospital Clinic (Barcelona, Spain).

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Appendix

Appendix

See Tables 5 and 6.

Table 5 Sociodemographic and clinical variables of the study population according to study cohort
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Table 6 Selection criteria for the four cross-sectional studies included in this analysis
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Esquinas, C., Ramon, M.A., Nuñez, A. et al. Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease. Qual Life Res 29, 607–617 (2020). https://doi.org/10.1007/s11136-019-02340-4

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