Abstract
In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization of substituted 2-aminobenzenethiols with β-ketoester. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.
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Acknowledgments
The authors are thankful to the head of the Department of Chemistry, University of Rajasthan, Jaipur (India) for providing the necessary laboratory facilities as well as instrumentation facilities (IR, and 1HNMR). The director of the RSIC, CDRI, Lucknow (India) is acknowledged for providing mass spectra of the synthesized compounds. We express our thanks to UGC, New Delhi, for providing a meritorious student fellowship to one of the authors (P.K.S.).
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Sharma, P.K., Fogla, A., Rathore, B.S. et al. Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem. Res Chem Intermed 37, 1103–1111 (2011). https://doi.org/10.1007/s11164-011-0320-0
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DOI: https://doi.org/10.1007/s11164-011-0320-0