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Synthesis of pterostilbene and resveratrol carbamate derivatives as potential dual cholinesterase inhibitors and neuroprotective agents

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Abstract

Pterostilbene and resveratrol carbamate derivatives were designed and synthesized by use of a multi-target directed drug-design strategy. Their acetylcholinesterase and butylcholinesterase inhibitory activity and neuroprotective effects against hydrogen peroxide-induced PC12 cell injury were evaluated in vitro. The results indicated that some of the compounds had dual inhibitory potency against acetylcholinesterase and butylcholinesterase, and potential neuroprotective effects, and could be considered as potential multi-target-directed agents.

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Acknowledgments

This work was financially supported by the Chinese National Natural Science Foundation (20672077, 20872099), the Research Fund for the Doctoral Program of Higher Education (20110181110079), and the National Science and Technology Major Project on “Key New Drug Creation and Manufacturing Program” (2013ZX09301304-002).

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Authors and Affiliations

  1. Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, Sichuan, China

    Wen Yuan, Zhipei Shang, Xiaoming Qiang & Yong Deng

  2. Sichuan Institute of Chinese Materia Medica, Chengdu, 610041, Sichuan, China

    Zhenghuai Tan

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  1. Wen Yuan
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  2. Zhipei Shang
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  3. Xiaoming Qiang
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  4. Zhenghuai Tan
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  5. Yong Deng
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Correspondence to Yong Deng.

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Yuan, W., Shang, Z., Qiang, X. et al. Synthesis of pterostilbene and resveratrol carbamate derivatives as potential dual cholinesterase inhibitors and neuroprotective agents. Res Chem Intermed 40, 787–800 (2014). https://doi.org/10.1007/s11164-012-1003-1

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  • DOI: https://doi.org/10.1007/s11164-012-1003-1

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