Abstract
Three related alkaloids, oxynitidine, nitidine and 5,6-dihydronitidine, have been afforded by the new synthetic protocols. In this approach, the Ni-catalyzed annulation reaction is indicated as the key step to construct the isoquinolinone core structure. The subsequent transformations lead to the target alkaloids.
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Acknowledgements
We thank the Ministry of Science and Technology of Taiwan (ROC) for the financial support of this research (MOST 107-2113-M-032-006) and the fellowship for Gangaram Pallikonda (MOST 107-2811-M-032-002).
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Pallikonda, G., Hsieh, CY., Su, HL. et al. A combined pathway for the synthesis of nitidine family alkaloids. Res Chem Intermed 45, 5399–5407 (2019). https://doi.org/10.1007/s11164-019-03977-z
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DOI: https://doi.org/10.1007/s11164-019-03977-z