Abstract
A synthesis of olanzapine, 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, was carried out and the conditions for its tritium labeling were optimized to obtain a tritium-labeled olanzapine preparation with a specific radioactivity of 12 Ci/mmol.
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Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 4, 2005, pp. 420–424.
Original Russian Text Copyright © 2005 by Shevchenko, Nagaev, Kuznetsov, Polunin, Zozulya, Myasoedov.
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Shevchenko, V.P., Nagaev, I.Y., Kuznetsov, Y.V. et al. A Synthesis of Tritium-Labeled Olanzapine. Russ J Bioorg Chem 31, 378–382 (2005). https://doi.org/10.1007/s11171-005-0052-2
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DOI: https://doi.org/10.1007/s11171-005-0052-2