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Crystal structure of amino acid peroxosolvates; X-ray diffraction study of norleucine peroxosolvate

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Abstract

Norleucine peroxosolvate 2Nle · 3H2O2 was studied by single-crystal X-ray diffraction. There are 16 crystallographically independent amino acid molecules and 24 hydrogen peroxide molecules per asymmetric unit of the crystal structure. The crystal packing of this compounds is typical of mesomorphic crystals. The loose layers of aliphatic moieties alternate with double layers formed by the functional groups of all structural units of the crystal through O-H⋯O or N-H⋯O hydrogen bonds. Some amino acid and hydrogen peroxide molecules are disordered. The character of disorder is considered in terms of frozen dynamics, which suggests the possible mechanism of the involvement of hydrogen peroxide in the transport of bulky natural molecules across cell membranes.

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Funding

This study was financially supported by the Russian Science Foundation (Project No 16-13-10273). We are sincerely grateful to A. G. Medvedev and P. V. Prikhodchenko (N. S. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences) for the crystallization of compound 1 from highly concentrated hydrogen peroxide.

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Authors and Affiliations

  1. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    L. G. Kuz’mina & A. V. Churakov

Authors
  1. L. G. Kuz’mina
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  2. A. V. Churakov
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Correspondence to L. G. Kuz’mina.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 283–291, February, 2022.

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Kuz’mina, L.G., Churakov, A.V. Crystal structure of amino acid peroxosolvates; X-ray diffraction study of norleucine peroxosolvate. Russ Chem Bull 71, 283–291 (2022). https://doi.org/10.1007/s11172-022-3409-2

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  • DOI: https://doi.org/10.1007/s11172-022-3409-2

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