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Hydrolytically stable organometallic ruthenium complexes with glucose-based phosphite ligands

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Abstract

New organometallic ruthenium complexes with glucose-based phosphite ligands bearing uracil, thymine, and 5-fluorouracil units as well as the bromide and iodide ligands were synthesized. Compounds bearing the bromide and iodide ligands were found to be more hydrolytically stable than their chloro counterparts. Antiproliferative activity of the synthesized compounds was evaluated against several cancer cell lines. It was found that these compounds are low toxic (IC50 > 100 μmol L−1) and their antiproliferative activity is independent of the nature of the halogen in their structure.

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Authors and Affiliations

  1. Department of Chemistry, Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    M. R. Gonchar, F. S. Ninin, E. R. Milaeva & A. A. Nazarov

Authors
  1. M. R. Gonchar
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  2. F. S. Ninin
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  3. E. R. Milaeva
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  4. A. A. Nazarov
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Corresponding author

Correspondence to A. A. Nazarov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 962–966, May, 2022.

This work was financially supported by the Russian Foundation for Basic Research (Project Nos 20-33-90081 and 19-53-12042).

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Gonchar, M.R., Ninin, F.S., Milaeva, E.R. et al. Hydrolytically stable organometallic ruthenium complexes with glucose-based phosphite ligands. Russ Chem Bull 71, 962–966 (2022). https://doi.org/10.1007/s11172-022-3497-z

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  • DOI: https://doi.org/10.1007/s11172-022-3497-z

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