Abstract
Radical polymerization was used to synthesize and characterize (co)polymers with sodium styrenesulfonate (NaSS), 4-methacryloylamidosalicylic acid (MASA), and N-vinylpyrrolidone, which have a low cytotoxicity and a high antiviral activity against the human respiratory syncytial virus. The interaction of copolymers with Tb3+ ions was studied. The complexes formed in dilute aqueous solutions at a concentration of MASA units c ⩽ 1 · 10−4 mol L−1 demonstrate a strong luminescence. The luminescence intensity is independent of copolymer composition, but increases when the NaSS units are substituted with uncharged N-vinylpyrrolidone units. The obtained Tb3+ polymer complexes are promising luminescent sensors for the visualization of biological objects interacting with copolymers.
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R. A. Anderson, K. Robert, A. Anderson, K. Feathergill, X. Diao, M. Cooper, R. Kirkpatrick, P. Spear, D. P. Waller, C. Chany, G. F. Doncel, B. Herold, L. J. D. Zaneveld, J. Andrology, 2000, 21, 862; DOI: https://doi.org/10.1002/j.1939-4640.2000.tb03417.x.
X. Jiang, Z. Li, D. J. Young, M. Liu, C. Wu, Y.-L. Wu, X. J. Loh, Mater. Today Adv., 2021, 10, 100140; DOI: https://doi.org/10.1016/j.mtadv.2021.100140.
P. Mastromarino, R. Petruzziello, J. Macchia, J. Rieti, R. Nicoletti, N. Orsi, J. Antimicrob. Chemother., 1997, 39, 339; DOI:https://doi.org/10.1093/jac/39.3.339.
M. Jabeen, M. Dutot, R. Fagon, B. Verrier, C. Monge, Pharmaceutics, 2021, 13, 733; DOI: https://doi.org/10.3390/pharmaceutics13050733.
F. Schandock, C. F. Riber, A. Röcker, J. A. Müller, M. Harms, P. Gajda, K. Zuwala, A. H. F. Andersen, K. B. Løvschall, M. Tolstrup, F. Keppel, J. Münch, A. N. Zelikin, Adv. Healthc. Mater., 2017, 6, 1700748; DOI: https://doi.org/10.1002/adhm.201700748.
M. Andrew, G. Jayaraman, Carbohydr. Res., 2021, 505, 108326; DOI: https://doi.org/10.1016/j.carres.2021.108326.
H. Mitsuya, D. J. Looney, J. Kuno, R. Ueno, F. S. Wong-Staal, Science, 1988, 240, 646; DOI: https://doi.org/10.1126/science.2452480.
J.-C. G. Bünzli, J. Lumin., 2016, 170, 866; DOI: https://doi.org/10.1016/j.jlumin.2015.07.033.
H. Kobayashi, M. Ogawa, R. Alford, P. L. Choyke, Y. Urano, Chem. Rev., 2010, 110, 2620; DOI: https://doi.org/10.1021/cr900263j.
V. V. Utochnikova, N. P. Kuzmina, Russ. J. Coord. Chem., 2016, 42, 679; DOI: https://doi.org/10.1134/s1070328416090074.
B. Gao, W. Zhang, Z. Zhang, Q. Lei, J. Lumin., 2012, 132, 2005; DOI: https://doi.org/10.1016/j.jlumin.2012.01.055.
T. Kh. Abdukhodzhayev, V. A. Kropachev, L. B. Trukhmanova, L. M. Vil’ner, in Fiziologicheski aktivnye polimernye veshchestva [Physiologically Active Polymer Compounds], Tashkent. gos. un-t, Tashkent, 1976, p. 170 (in Russian).
M. Niks, M. Otto, J. Immunol. Methods, 1990, 130, 149; DOI: https://doi.org/10.1016/0022-1759(90)90309-j.
L. J. Reed, H. Muench, Am. J. Hygiene, 1938, 27, 493; DOI: https://doi.org/10.1093/oxfordjournals.aje.a118408.
K. Binnemans, Coord. Chem. Rev., 2015, 295, 1; DOI: https://doi.org/10.1016/j.ccr.2015.02.015.
V. V. Utochnikova, Coord. Chem. Rev., 2019, 398, 113006; DOI: https://doi.org/10.1016/j.ccr.2019.07.003.
C. P. Montgomery, E. J. New, D. Parker, R. D. Peacock, Chem. Commun., 2008, 4261; DOI: https://doi.org/10.1039/b810978h.
S. J. Bao, Z. Zhan, R. Tang, H. Han, J. Lumin., 2013, 136, 68; DOI: https://doi.org/10.1016/j.jlumin.2012.11.006.
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The work was carried out within the framework of the Russin state assignment of the Institute of Macromolecular Compounds of the Russian Academy of Sciences (registration number 122012100171-8, synthesis and physicochemical studies) with the financial support of the National World-Class Center for Advanced Digital Technologies (biological testing, within the framework of the Agreement on the provision of a grant in the form of subsidies from the federal budget for the implementation of state support for the establishment and development of scientific centers for research and development of scientific and technological development priorities dated 20.04.2022 No. 075-15-2022-313).
No human or animal subjects were used in this research.
The authors declare no competing interests.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2352–2357, November, 2022.
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Panarin, E.F., Fischer, A.I., Nesterova, N.A. et al. Luminescent polyelectrolytes with antiviral activity. Russ Chem Bull 71, 2352–2357 (2022). https://doi.org/10.1007/s11172-022-3662-4
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DOI: https://doi.org/10.1007/s11172-022-3662-4