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Microwave-assisted synthesis of amides from various amines and benzoyl chloride under solvent-free conditions: A rapid and efficient method for selective protection of diverse amines

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Abstract

A number of structurally diverse amides were synthesized by reaction of the corresponding amines with benzoyl chloride under microwave irradiation. The proposed procedure ensures short reaction time, high yields, and excellent selectivity and considerably broadens the series of amines as compared to the microwave-assisted synthesis of amides directly from carboxylic acids. It can also be used for selective protection of various amines, including aromatic, aliphatic, and heterocyclic.

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Authors and Affiliations

  1. College of Chemistry and Environmental Science, Key Laboratory of Environmental Pollution Control Technology of Henan Province, Henan Normal University, Xinxiang, Henan, 453007, P.R. China

    Yanqiu Li

  2. Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, P.R. China

    Yulu Wang

  3. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P.R. China

    Jinye Wang

Authors
  1. Yanqiu Li
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  2. Yulu Wang
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  3. Jinye Wang
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Corresponding author

Correspondence to Yanqiu Li.

Additional information

Published in Russian in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 3, pp. 365–368.

The text was submitted by the authors in English.

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Li, Y., Wang, Y. & Wang, J. Microwave-assisted synthesis of amides from various amines and benzoyl chloride under solvent-free conditions: A rapid and efficient method for selective protection of diverse amines. Russ J Org Chem 44, 358–361 (2008). https://doi.org/10.1134/S1070428008030081

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  • DOI: https://doi.org/10.1134/S1070428008030081

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