Skip to main content
SpringerLink
Log in

Phosphodiester hydrolysis promoted by dinuclear iron(III) complexes

  • Published:
Transition Metal Chemistry Aims and scope Submit manuscript

Abstract

We report the reactivity of three binuclear non-heme Fe(III) compounds, namely [Fe2(bbppnol)(μ-AcO)(H2O)2](ClO4)2 (1), [Fe2(bbppnol)(μ-AcO)2](PF6) (2), and [Fe2(bbppnol)(μ-OH)(Cl)2]·6H2O (3), where H3bbppnol = N,N′-bis(2-hydroxybenzyl)-N,N′-bis(2-methylpyridyl)–1,3-propanediamine-2-ol, toward the hydrolysis of bis-(2,4-dinitrophenyl)phosphate as models for phosphoesterase activity. The synthesis and characterization of the new complexes 1 and 3 was also described. The reactivity differences observed for these complexes show that the accessibility of the substrate to the reaction site is one of the key steps that determinate the hydrolysis efficiency.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Mitic N, Smith SJ, Neves A, Guddat LW, Gahan LR, Schenk W (2006) Chem Rev 106:3338

    Article  CAS  Google Scholar 

  2. Calvo-Marzal P, Rosatto SS, Granjeiro PA, Aoyama H, Kubota LT (2001) Anal Chim Acta 441:207

    Article  CAS  Google Scholar 

  3. Saedd A, Tremori E, Manao G, Camici G, Cappugi G, Ramponi G (1990) Physiol Chem Phys M 22:81

    Google Scholar 

  4. Hollander VP (1971) In: Boyer PD (ed) The enzymes, vol 1V A. Academic Press, New York

  5. Biswas TK, Cundiff C (1991) Phytochemistry 30:2119

    Article  CAS  Google Scholar 

  6. Panara F, Pasqualini S, Antonielli M (1990) Biochim Boiphys Acta 1037:73

    Article  CAS  Google Scholar 

  7. Staswick PE, Papa C, Huang J, Rhee Y (1994) Plant Physiol 104:49

    CAS  Google Scholar 

  8. Gellatly KS, Moorhead GBG, Duff SMG, Lefebvre DD, Plaxton WC (1994) Plant Physiol 106:223

    CAS  Google Scholar 

  9. Guo J, Pesacreta TC (1997) J Plant Physiol 151:520

    CAS  Google Scholar 

  10. Wang R, Cai Q, Tong D, Nie L, Yao S (1998) Enzyme Microbiol Technol 22:36

    Article  CAS  Google Scholar 

  11. Hudson PB, Tsuboi KK, Mittelman A (1995) Am J Med 19:895

    Article  Google Scholar 

  12. Iqbal SJ (1998) Clin Chim Acta 271:213

    Article  CAS  Google Scholar 

  13. Serpersu EH, Shortle D, Mildvan AS (1987) Biochemistry 26:1289

    Article  CAS  Google Scholar 

  14. Deal KA, Burstyn JN (1996) Inorg Chem 35:2792

    Article  CAS  Google Scholar 

  15. Hendry P, Sargeson AM (1990) In: Lippard SJ (ed) Progress in inorganic chemistry, vol 38. Wiley, New York

  16. Gahan LR, Smith SJ, Neves A, Schenk G (2009) Eur J Inorg Chem 2745

  17. Neves A, de Brito MA, Drago V, Griesar K, Haase W (1995) Inorg Chim Acta 237:131

    Article  CAS  Google Scholar 

  18. Karsten P, Neves A, Bortoluzzi AJ, Lanznaster M, Drago V (2002) Inorg Chem 41:4624

    Article  CAS  Google Scholar 

  19. Lanznaster M, Neves A, Bortoluzzi AJ, Szpoganicz B, Schwingel E (2002) Inorg Chem 41:5641

    Article  CAS  Google Scholar 

  20. Lanznaster M, Neves A, Bortoluzzi AJ, Aires VVE, Szpoganicz B, Terenzi H, Severino PC, Fuller JM, Drew SC, Gahan LR, Hanson GR, Riley MJ, Schenk G (2005) J Biol Inorg Chem 10:319

    Article  CAS  Google Scholar 

  21. Neves A, Lanznaster M, Bortoluzzi AJ, Peralta RA, Casellato A, Castellano EE, Herrald P, Riley MJ, Schenk G (2007) J Am Chem Soc 129:7486

    Article  CAS  Google Scholar 

  22. Rawji GH, Yamada M, Sadler NP, Milburn RM (2000) Inorg Chim Acta 303:168

    Article  CAS  Google Scholar 

  23. Kimura E (2000) Curr Opin Chem Biol 4:207

    Article  CAS  Google Scholar 

  24. Fontecave M, Ménage S, Duboc-Toia C (1998) Coord Chem Rev 178:1555

    Article  Google Scholar 

  25. Neves A, Drechsel SM (1992) Inorg Chim Acta 197:121

    Article  CAS  Google Scholar 

  26. Longhinotti E, Domingos JB, Szpoganicz B, Neves A, Nome F (2005) Inorg Chim Acta 358:2089

    Article  CAS  Google Scholar 

  27. Nakamoto K (1997) In: Infrared and Raman Spectra of inorganic and coordination compounds. Wiley, New York

  28. Gaber BP, Miskoswski V, Spiro TG (1974) J Am Chem Soc 96:6868

    Article  CAS  Google Scholar 

  29. Ainscough EW, Brodie AM, Plowman JE, Brown KL, Addison AW, Gainsford AR (1980) Inorg Chem 19:3655

    Article  CAS  Google Scholar 

  30. Viswanathan R (1996) J Chem Soc Dalton Trans 2519

  31. Geary WJ (1971) Coord Chem Rev 7:81

    Article  CAS  Google Scholar 

  32. Drüeke S, Wieghardt K, Nuber B, Weiss J, Fleischhauer H-P, Gehring S, Haase W (1989) J Am Chem Soc 111:8622

    Article  Google Scholar 

  33. Bunton CA, Farber SJ (1969) J Org Chem 34:767

    Article  CAS  Google Scholar 

  34. Krebs B, Than R, Feldmann A (1999) Coord Chem Rev 182:211

    Article  Google Scholar 

  35. Lanznaster M, Neves A, Bortoluzzi AJ, Szpoganicz B, Schwingel E (2002) Inorg Chem 22:5641

    Article  Google Scholar 

  36. Twitchett MB (2002) Inorg Chem 41:5787

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação Araucária, Fundação da Universidade Federal do Paraná (FUNPAR) and Universidade Federal do Paraná (UFPR) for the financial support and fellowships. They gratefully acknowledge Msc. Geraldo R. Friedermann and Dr Antonio S. Mangrich for the EPR facilities and analyses.

Author information

Authors and Affiliations

  1. Laboratório de Química Bioinorgânica e Catálise, Departamento de Química, Universidade Federal do Paraná, C.P. 19081, Curitiba, PR, CEP 81531-970, Brazil

    Clovis Piovezan, Fábio da Silva Lisboa, Fábio Souza Nunes & Sueli Maria Drechsel

Authors
  1. Clovis Piovezan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fábio da Silva Lisboa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fábio Souza Nunes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sueli Maria Drechsel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sueli Maria Drechsel.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 78 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piovezan, C., da Silva Lisboa, F., Nunes, F.S. et al. Phosphodiester hydrolysis promoted by dinuclear iron(III) complexes. Transition Met Chem 36, 79–85 (2011). https://doi.org/10.1007/s11243-010-9437-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11243-010-9437-z

Keywords

Search

Navigation