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Analysis of vitamin D deficiency in calcium stone-forming patients

  • Urology - Original Paper
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Abstract

Purpose

The aim of this study is to analyse the percentage of hypovitaminosis D, as well as its relationship with the various parameters of calcium-phosphate metabolism.

Methods

A case control study was conducted on 366 patients, divided into two groups: Group 1: 127 non-stone-forming patients, and Group 2: 239 calcium stone forming. A study was performed on calcium-phosphate metabolism and urinary lithogenic factors. The percentage of vitamin D deficiency (25-OH-vitamin D levels <20 ng/ml) between the groups was analysed and compared. The SPSS 20.0 statistics program was used for the analysis, with a p ≤ .05 being considered significant.

Results

The mean age of Group 1 was 52.1 years compared to 49.6 years in Group 2, with no significant differences (p = .07). Vitamin D levels were lower in Group 2 compared to Group 1 (25.7 vs. 28.4 ng/ml, p = .02). A vitamin D deficiency was observed in 28 % of the Group 2 stone-forming patients versus 15.7 % in Group 1 (p = .009), with an odds ratio (OR) of 2.09 (95 % CI; 1.19–3.63). In the stone-forming patients with a vitamin D deficiency, the only difference observed was the higher levels of iPTH compared to those stone-formers with a normal vitamin D (56.9 vs. 45.5 pg/ml, respectively; p = .0001).

Conclusion

Calcium stone-forming patients have lower mean levels of vitamin D and a higher percentage of hypovitaminosis D than in non-stone-forming patients. This was only related to increased iPTH levels, with urine calcium and other lithogenic parameters having no obvious effect.

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Acknowledgments

To Programa de Doctorado de Medicina Clínica y Salud Pública. Trabajo de tesis doctoral de María Sierra Girón Prieto dirigido por Miguel Ángel Arraba-Polo y Salvador Arias Santiago.

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Authors and Affiliations

  1. Primary Care, Health Centre of Pinos Puente, Programa de Doctorado de Medicina Clínica y Salud Pública, Granada University, Granada, Spain

    María Sierra Girón-Prieto

  2. Institute IBS Granada, Plaza Ciudad de los Cármenes, No. 4, Granada, Spain

    María del Carmen Cano-García & Miguel Ángel Arrabal-Polo

  3. Biochemical Department, Santa Ana Hospital, Granada, Spain

    Antonio Poyatos-Andujar

  4. Endocrinology Department, Granada University Hospital, Granada, Spain

    Miguel Quesada-Charneco

  5. Biochemical Department, Granada University Hospital, Granada, Spain

    Tomás de Haro-Muñoz

  6. Medicine Department, Granada University, Granada, Spain

    Salvador Arias-Santiago

  7. Surgery Department, Institute IBS Granada, Granada University, Granada, Spain

    Miguel Arrabal-Martín

Authors
  1. María Sierra Girón-Prieto
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  2. María del Carmen Cano-García
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  3. Miguel Ángel Arrabal-Polo
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  4. Antonio Poyatos-Andujar
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  5. Miguel Quesada-Charneco
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  6. Tomás de Haro-Muñoz
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  7. Salvador Arias-Santiago
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  8. Miguel Arrabal-Martín
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Corresponding author

Correspondence to Miguel Ángel Arrabal-Polo.

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Conflict of interest

The authors declare no conflict of interest

Ethical statement

It is a low ethically responsible study in which the patients gave their informed consent after reading the Patient Information Sheet. The study was approved by the Hospital Ethics Committee.

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Girón-Prieto, M.S., del Carmen Cano-García, M., Arrabal-Polo, M.Á. et al. Analysis of vitamin D deficiency in calcium stone-forming patients. Int Urol Nephrol 48, 1243–1246 (2016). https://doi.org/10.1007/s11255-016-1290-3

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  • DOI: https://doi.org/10.1007/s11255-016-1290-3

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