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Biogenic synthesis of multifunctional silver nanoparticles from Rhodotorula glutinis and Rhodotorula mucilaginosa: antifungal, catalytic and cytotoxicity activities

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Abstract

Silver nanoparticles (AgNPs) have several technological applications and may be synthetized by chemical, physical and biological methods. Biosynthesis using fungi has a wide enzymatic range and it is easy to handle. However, there are few reports of yeasts with biosynthetic ability to produce stable AgNPs. The purpose of this study was to isolate and identify soil yeasts (Rhodotorula glutinis and Rhodotorula mucilaginosa). After this step, the yeasts were used to obtain AgNPs with catalytic and antifungal activity evaluation. Silver Nanoparticles were characterized by UV–Vis, DLS, FTIR, XRD, EDX, SEM, TEM and AFM. The AgNPs produced by R. glutinis and R. mucilaginosa have 15.45 ± 7.94 nm and 13.70 ± 8.21 nm (average ± SD), respectively, when analyzed by TEM. AgNPs showed high catalytic capacity in the degradation of 4-nitrophenol and methylene blue. In addition, AgNPs showed high antifungal activity against Candida parapsilosis and increase the activity of fluconazole (42.2% for R. glutinis and 29.7% for R. mucilaginosa), while the cytotoxicity of AgNPs was only observed at high concentrations. Finally, two yeasts with the ability to produce AgNPs were described and these particles showed multifunctionality and can represent a technological alternative in many different areas with potential applications.

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Acknowledgements

The authors gratefully thank the Central Analítica-UFC/CT-INFRA/MCTI-SISNANO/Pró-Equipamentos, Departamento de Física da UFC, CAPES, CNPq (408790/2016-4) and Funcap (PNE-0112-00048.01.00/16), for the grant provided to support the research on nanoparticles.

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  1. Grupo de Química de Materiais Avançados (GQMat)- Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará – UFC, Campus do Pici, CP 12100, CEP 60451-970, Fortaleza, CE, Brazil

    Francisco A. Cunha, Eduardo J. J. Mallmann, Tiago M. Freire & Pierre B. A. Fechine

  2. Laboratório de Microbiologia de Leveduras – Departamento de Análises Clínicas, Universidade Federal do Ceará – UFC, Fortaleza, Brazil

    Francisco A. Cunha, Maria da C. S. O. Cunha, Sabrina M. da Frota & Everardo A. Menezes

  3. Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa Em Energia e Materiais (CNPEM), CEP 13083-970, Campinas, São Paulo, Brazil

    Luelc S. Costa

  4. Solid-Biological Interface Group (SolBIN), Departamento de Física, Universidade Federal do Ceará, P.O. Box 6030, Fortaleza, CE, 60455-900, Brazil

    Amauri J. Paula

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  1. Francisco A. Cunha
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  2. Maria da C. S. O. Cunha
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  3. Sabrina M. da Frota
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  8. Everardo A. Menezes
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  9. Pierre B. A. Fechine
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Correspondence to Pierre B. A. Fechine.

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Cunha, F.A., Cunha, M.d.C.S.O., da Frota, S.M. et al. Biogenic synthesis of multifunctional silver nanoparticles from Rhodotorula glutinis and Rhodotorula mucilaginosa: antifungal, catalytic and cytotoxicity activities. World J Microbiol Biotechnol 34, 127 (2018). https://doi.org/10.1007/s11274-018-2514-8

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