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Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems

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Abstract

The functions of P2X purinoceptors (P2X1-7) in the nervous system of adults have been widely studied. However, little is known about their roles during embryonic development. Our previous work has reported an extensive expression of P2X5 receptors in the adult mouse central nervous system. In the present study, we have examined the expression pattern of P2X5 receptor mRNA and protein during prenatal development of the mouse nervous system (from embryonic day E8 to E17). P2X5 receptors appeared in the neural tube as early as E8 and were gradually confined to new-born neurons in the cortical plate and ventral horn of the spinal cord. Heavy signals for P2X5 receptors were also found in dorsal root ganglia (DRG), retina, olfactory epithelium, and nerve fibers in skeletal muscles. In conclusion, P2X5 receptors were strongly represented in the developing mouse nervous system. The transient high expression pattern of P2X5 receptors in epithelium-like structures suggests a role during early neurogenesis.

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Acknowledgments

The authors thank Dr. Gillian E. Knight for her excellent editorial assistance. This work was supported by 973 Program (2011CB504401 to Z. Xiang) and the National Natural Science Foundation of the People’s Republic of China (30970918 to Z. Xiang).

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Correspondence to Zhenghua Xiang or Cheng He.

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W Guo and Z Zhang contributed equally to this work.

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Guo, W., Zhang, Z., Liu, X. et al. Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems. Purinergic Signalling 9, 239–248 (2013). https://doi.org/10.1007/s11302-012-9346-z

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  • DOI: https://doi.org/10.1007/s11302-012-9346-z

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