Skip to main content
Log in

Purinergic signalling in the kidney in health and disease

  • Review Article
  • Published:
Purinergic Signalling Aims and scope Submit manuscript

Abstract

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. AbouAlaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, Nauli SM (2009) Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ Res 104:860–869

    PubMed Central  PubMed  CAS  Google Scholar 

  2. Aguiari G, Varani K, Bogo M, Mangolini A, Vincenzi F, Durante C, Gessi S, Sacchetto V, Catizone L, Harris P, Rizzuto R, Borea PA, Del Senno L (2009) Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A3 adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells. Biochim Biophys Acta 1792:531–540

    PubMed  CAS  Google Scholar 

  3. Akimova AO, Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, Orlov SN (2005) Cl secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P2Y1 receptors, phospholipase A2 and protein kinase A. J Physiol 568:789–801

    PubMed Central  PubMed  CAS  Google Scholar 

  4. Akimova OA, Grygorczyk A, Bundey RA, Bourcier N, Gekle M, Insel PA, Orlov SN (2006) Transient activation and delayed inhibition of Na+, K+, Cl − cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem 281:31317–31325

    PubMed  CAS  Google Scholar 

  5. Akimova OA, Taurin S, Dulin NO, Orlov SN (2008) Purinergic inhibition of Na+, K+, Cl − cotransport in C11-MDCK cells: role of stress-activated protein kinases. Purinergic Signal 4:183–191

    PubMed Central  PubMed  CAS  Google Scholar 

  6. Amann K, Veelken R (2003) Mechanisms and consequences of sympathetic hyperactivity in renal disease. Clin Nephrol 60(Suppl 1):S81–S92

    PubMed  Google Scholar 

  7. Apicella L, Fabbretti E (2012) P2X3 receptor expression by HEK cells conditions their survival. Purinergic Signal 8:295–300

    PubMed Central  PubMed  CAS  Google Scholar 

  8. Assaife-Lopes N, Wengert M, Pinheiro AA, Landgraf SS, Paes-de-Carvalho R, Leao-Ferreira LR, Caruso-Neves C (2009) Adenosine deamination to inosine in isolated basolateral membrane from kidney proximal tubule: implications for modulation of the membrane-associated protein kinase A. Arch Biochem Biophys 486:44–50

    PubMed  CAS  Google Scholar 

  9. Awad AS, Rouse M, Liu L, Vergis AL, Rosin DL, Linden J, Sedor JR, Okusa MD (2008) Activation of adenosine 2A receptors preserves structure and function of podocytes. J Am Soc Nephrol 19:59–68

    PubMed Central  PubMed  CAS  Google Scholar 

  10. Bagorda A, Guerra L, Di SF, Helmle-Kolb C, Favia M, Jacobson KA, Casavola V, Reshkin SJ (2002) Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism. J Membr Biol 188:249–259

    PubMed  CAS  Google Scholar 

  11. Bailey MA (2004) Inhibition of bicarbonate reabsorption in the rat proximal tubule by activation of luminal P2Y1 receptors. Am J Physiol Ren Physiol 287:F789–F796

    CAS  Google Scholar 

  12. Bailey MA, Shirley DG (2009) Effects of extracellular nucleotides on renal tubular solute transport. Purinergic Signal 5:473–480

    PubMed Central  PubMed  CAS  Google Scholar 

  13. Bailey MA, Hillman KA, Unwin RJ (2000) P2 receptors in the kidney. J Auton Nerv Syst 81:264–270

    PubMed  CAS  Google Scholar 

  14. Bailey MA, Imbert-Teboul M, Turner C, Marsy S, Srai K, Burnstock G, Unwin RJ (2000) Axial distribution and characterization of basolateral P2Y receptors along the rat renal tubule. Kidney Int 58:1893–1901

    PubMed  CAS  Google Scholar 

  15. Bailey MA, Imbert-Teboul M, Turner C, Srai SK, Burnstock G, Unwin RJ (2001) Evidence for basolateral P2Y6 receptors along the rat proximal tubule: functional and molecular characterization. J Am Soc Nephrol 12:1640–1647

    PubMed  CAS  Google Scholar 

  16. Bailey MA, Turner CM, Hus-Citharel A, Marchetti J, Imbert-Teboul M, Milner P, Burnstock G, Unwin RJ (2004) P2Y receptors present in the native and isolated rat glomerulus. Nephron Physiol 96:79–90

    Google Scholar 

  17. Bailey MA, Unwin RJ, Shirley DG (2012) P2X receptors and kidney function. WIREs Memb Transplant Signal 1:503–511. doi:10.1002/wmts.40

    CAS  Google Scholar 

  18. Balakrishnan VS, von Ruhland CJ, Griffiths DF, Coles GA, Williams JD (1996) Effects of a selective adenosine A1 receptor antagonist on the development of cyclosporin nephrotoxicity. Br J Pharmacol 117:879–884

    PubMed Central  PubMed  CAS  Google Scholar 

  19. Banderali U, Brochiero E, Lindenthal S, Raschi C, Bogliolo S, Ehrenfeld J (1999) Control of apical membrane chloride permeability in the renal A6 cell line by nucleotides. J Physiol 519(Pt 3):737–751

    PubMed Central  PubMed  CAS  Google Scholar 

  20. Bauerle JD, Grenz A, Kim JH, Lee HT, Eltzschig HK (2011) Adenosine generation and signaling during acute kidney injury. J Am Soc Nephrol 22:14–20

    PubMed  CAS  Google Scholar 

  21. Bell PD, Lapointe JY, Sabirov R, Hayashi S, Peti-Peterdi J, Manabe K, Kovacs G, Okada Y (2003) Macula densa cell signaling involves ATP release through a maxi anion channel. Proc Natl Acad Sci U S A 100:4322–4327

    PubMed Central  PubMed  CAS  Google Scholar 

  22. Bell PD, Komlosi P, Zhang ZR (2009) ATP as a mediator of macula densa cell signalling. Purinergic Signal 5:461–471

    PubMed Central  PubMed  CAS  Google Scholar 

  23. Belzer FO, Sollinger HW, Glass NR, Miller DT, Hoffmann RM, Southard JH (1983) Beneficial effects of adenosine and phosphate in kidney preservation. Transplantation 36:633–635

    PubMed  CAS  Google Scholar 

  24. Bertelli R, Bodria M, Nobile M, Alloisio S, Barbieri R, Montobbio G, Patrone P, Ghiggeri GM (2011) Regulation of innate immunity by the nucleotide pathway in children with idiopathic nephrotic syndrome. Clin Exp Immunol 166:55–63

    PubMed Central  PubMed  CAS  Google Scholar 

  25. Bhat SG, Mishra S, Mei Y, Nie Z, Whitworth CA, Rybak LP, Ramkumar V (2002) Cisplatin up-regulates the adenosine A1 receptor in the rat kidney. Eur J Pharmacol 442:251–264

    PubMed  CAS  Google Scholar 

  26. Bidet M, De Renzis G, Martial S, Rubera I, Tauc M, Poujeol P (2000) Extracellular ATP increases [CA2+]i in distal tubule cells. I. Evidence for a P2Y2 purinoceptor. Am J Physiol Ren Physiol 279:F92–F101

    CAS  Google Scholar 

  27. Blantz RC, Singh P, Deng A, Thomson SC, Vallon V (2012) Acute saline expansion increases nephron filtration and distal flow rate but maintains tubuloglomerular feedback responsiveness: role of adenosine A1 receptors. Am J Physiol Ren Physiol 303:F405–F411

    CAS  Google Scholar 

  28. Boone M, Deen PM (2008) Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Pflugers Arch 456:1005–1024

    PubMed Central  PubMed  CAS  Google Scholar 

  29. Boone M, Kortenoeven ML, Robben JH, Tamma G, Deen PM (2011) Counteracting vasopressin-mediated water reabsorption by ATP, dopamine, and phorbol esters: mechanisms of action. Am J Physiol Ren Physiol 300:F761–F771

    CAS  Google Scholar 

  30. Booth JW, Tam FW, Unwin RJ (2012) P2 purinoceptors: Renal pathophysiology and therapeutic potential. Clin Nephrol 78:154–163

    PubMed  CAS  Google Scholar 

  31. Bourcier N, Grygorczyk R, Gekle M, Berthiaume Y, Orlov SN (2002) Purinergic-induced ion current in monolayers of C7-MDCK cells: role of basolateral and apical ion transporters. J Membr Biol 186:131–143

    PubMed  CAS  Google Scholar 

  32. Bouyer P, Paulais M, Cougnon M, Hulin P, Anagnostopoulos T, Planelles G (1998) Extracellular ATP raises cytosolic calcium and activates basolateral chloride conductance in Necturus proximal tubule. J Physiol 510:535–548

    PubMed Central  PubMed  CAS  Google Scholar 

  33. Brown JN, Payne BL, Smith TM, Sulya LL (1977) Effects of ATP, NADH and aldosterone on citrate synthase from bovine kidney cortex. Int J Biochem 8:437–440

    CAS  Google Scholar 

  34. Brown R, Ollerstam A, Johansson B, Skøtt O, Gebre-Medhin S, Fredholm B, Persson AE (2001) Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 281:R1362–R1367

    PubMed  CAS  Google Scholar 

  35. Brunette MG, Mailloux J, Hilal G (1999) ATP directly enhances calcium channels in the luminal membrane of the distal nephron. J Cell Physiol 181:416–423

    PubMed  CAS  Google Scholar 

  36. Buchholz B, Teschemacher B, Schley G, Schillers H, Eckardt KU (2011) Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion. J Mol Med (Berl) 89:251–261

    CAS  Google Scholar 

  37. Bugaj V, Sansom SC, Wen D, Hatcher LI, Stockand JD, Mironova E (2012) Flow-sensitive K+-coupled ATP secretion modulates activity of the epithelial Na+ channel in the distal nephron. J Biol Chem 287:38552–38558

    PubMed Central  PubMed  CAS  Google Scholar 

  38. Bührle CP, Scholz H, Nobiling R, Taugner R (1986) Junctional transmission in renin-containing and smooth muscle cells of the afferent arteriole. Pflugers Arch 406:578–586

    PubMed  Google Scholar 

  39. Burnstock G (2002) Purinergic signalling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol 22:364–373

    PubMed  Google Scholar 

  40. Burnstock G, Knight GE (2004) Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240:31–304

    PubMed  CAS  Google Scholar 

  41. Cabral PD, Garvin JL (2011) Flow-induced NO production is dependent on TRPV4 activation and ATP release in thick ascending limbs. FASEB J 25:666

    Google Scholar 

  42. Cadillo-Chávez R, de Echegaray S, Santiago-Delpín EA, Rodríguez-Trinidad AT, Camacho-Carrazo B, Alfaro T, Saavedra-Pozo M, Carrasquillo L, González-Caraballo ZA, Morales-Otero LA (2006) Assessing the risk of infection and rejection in Hispanic renal transplant recipients by means of an adenosine triphosphate release assay. Transplant Proc 38:918–920

    PubMed  Google Scholar 

  43. Capecchi PL, Rechichi S, Lazzerini PE, Collini A, Guideri F, Ruggieri G, Carmellini M, Laghi-Pasini F (2005) Cyclosporin and tacrolimus increase plasma levels of adenosine in kidney transplanted patients. Transpl Int 18:289–295

    PubMed  CAS  Google Scholar 

  44. Carlström M, Wilcox CS, Welch WJ (2010) Adenosine A2 receptors modulate tubuloglomerular feedback. Am J Physiol Ren Physiol 299:F412–F417

    Google Scholar 

  45. Carroll MA, Cheng MK, Liclican EL, Li J, Doumad AB, McGiff JC (2005) Purinoceptors in renal microvessels: adenosine-activated and cytochrome P450 monooxygenase-derived arachidonate metabolites. Pharmacol Rep 57(Suppl):191–195

    PubMed  Google Scholar 

  46. Castrop H (2007) Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine. Acta Physiol (Oxf) 189:3–14

    CAS  Google Scholar 

  47. Castrop H, Huang Y, Hashimoto S, Mizel D, Hansen P, Theilig F, Bachmann S, Deng C, Briggs J, Schnermann J (2004) Impairment of tubuloglomerular feedback regulation of GFR in ecto-5′-nucleotidase/CD73-deficient mice. J Clin Invest 114:634–642

    PubMed Central  PubMed  CAS  Google Scholar 

  48. Cha SH, Jung KY, Endou H (1995) Effect of P2Y-purinoceptor stimulation on renal gluconeogenesis in rats. Biochem Biophys Res Commun 211:454–461

    PubMed  CAS  Google Scholar 

  49. Cha SH, Sekine T, Endou H (1998) P2 purinoceptor localization along rat nephron and evidence suggesting existence of subtypes P2Y1 and P2Y2. Am J Physiol 274:F1006–F1014

    PubMed  CAS  Google Scholar 

  50. Chabardes-Garonne D, Mejean A, Aude JC, Cheval L, Di SA, Gaillard MC, Imbert-Teboul M, Wittner M, Balian C, Anthouard V, Robert C, Segurens B, Wincker P, Weissenbach J, Doucet A, Elalouf JM (2003) A panoramic view of gene expression in the human kidney. Proc Natl Acad Sci U S A 100:13710–13715

    PubMed Central  PubMed  CAS  Google Scholar 

  51. Chan CM, Unwin RJ, Bardini M, Oglesby IB, Ford APDW, Townsend-Nicholson A, Burnstock G (1998) Localization of the P2X1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys. Am J Physiol 274:F799–F804

    PubMed  CAS  Google Scholar 

  52. Chang MY, Lu JK, Tian YC, Chen YC, Hung CC, Huang YH, Chen YH, Wu MS, Yang CW, Cheng YC (2011) Inhibition of the P2X7 receptor reduces cystogenesis in PKD. J Am Soc Nephrol 22:1696–1706

    PubMed Central  PubMed  CAS  Google Scholar 

  53. Chapin HC, Caplan MJ (2010) The cell biology of polycystic kidney disease. J Cell Biol 191:701–710

    PubMed Central  PubMed  CAS  Google Scholar 

  54. Chen K, Zhang J, Zhang W, Zhang J, Yang J, Li K, He Y (2013) ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy. Int J Biochem Cell Biol 45:932–943

    PubMed  CAS  Google Scholar 

  55. Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386–396

    PubMed  CAS  Google Scholar 

  56. Chittezhath M, Frump AL, Jourquin J, Lobdell N, Eid JE (2008) The proto-oncoprotein SYT (SS18) controls ATP release and regulates cyst formation by polarized MDCK cells. Exp Cell Res 314:3551–3562

    PubMed Central  PubMed  CAS  Google Scholar 

  57. Churchill PC, Bidani AK (1982) Hypothesis: adenosine mediates hemodynamic changes in renal failure. Med Hypotheses 8:275–285

    PubMed  CAS  Google Scholar 

  58. Churchill PC, Churchill MC (1985) A1 and A2 adenosine receptor activation inhibits and stimulates renin secretion of rat renal cortical slices. J Pharmacol Exp Ther 232:589–594

    PubMed  CAS  Google Scholar 

  59. Churchill PC, Ellis VR (1993) Purinergic P2Y receptors stimulate renin secretion by rat renal cortical slices. J Pharmacol Exp Ther 266:160–163

    PubMed  CAS  Google Scholar 

  60. Cotrina ML, Lin JH, ves-Rodrigues A, Liu S, Li J, zmi-Ghadimi H, Kang J, Naus CC, Nedergaard M (1998) Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A 95(ves-Rodrigues A):15735–15740

    PubMed Central  PubMed  CAS  Google Scholar 

  61. Crawford C, Kennedy-Lydon TM, Callaghan H, Sprott C, Simmons RL, Sawbridge L, Syme HM, Unwin RJ, Wildman SS, Peppiatt-Wildman CM (2011) Extracellular nucleotides affect pericyte-mediated regulation of rat in situ vasa recta diameter. Acta Physiol (Oxf) 202:241–251

    CAS  Google Scholar 

  62. Cruthirds DL, Saba H, Millan-Crow LA (2005) Overexpression of manganese superoxide dismutase protects against ATP depletion-mediated cell death of proximal tubule cells. Arch Biochem Biophys 437:96–105

    PubMed  CAS  Google Scholar 

  63. Cuffe JE, Bielfeld-Ackermann A, Thomas J, Leipziger J, Korbmacher C (2000) ATP stimulates Cl secretion and reduces amiloride-sensitive Na+ absorption in M-1 mouse cortical collecting duct cells. J Physiol 524:77–90

    PubMed Central  PubMed  CAS  Google Scholar 

  64. Cupples WA, Braam B (2007) Assessment of renal autoregulation. Am J Physiol Ren Physiol 292:F1105–F1123

    CAS  Google Scholar 

  65. Dai Y, Zhang W, Wen J, Zhang Y, Kellems RE, Xia Y (2011) A2B adenosine receptor-mediated induction of IL-6 promotes CKD. J Am Soc Nephrol 22:890–901

    PubMed Central  PubMed  CAS  Google Scholar 

  66. Davies JP, Robson L (2010) Pharmacological properties and physiological function of a P2X-like current in single proximal tubule cells isolated from frog kidney. J Membr Biol 237:79–91

    PubMed Central  PubMed  CAS  Google Scholar 

  67. Deetjen P, Thomas J, Lehrmann H, Kim SJ, Leipziger J (2000) The luminal P2Y receptor in the isolated perfused mouse cortical collecting duct. J Am Soc Nephrol 11:1798–1806

    PubMed  CAS  Google Scholar 

  68. Di Garbo A, Alloisio S, Nobile M (2012) P2X7 receptor-mediated calcium dynamics in HEK293 cells: experimental characterization and modelling approach. Phys Biol 9:026001

    PubMed  Google Scholar 

  69. Di Sole F (2008) Adenosine and renal tubular function. Curr Opin Nephrol Hypertens 17:399–407

    PubMed  Google Scholar 

  70. Díaz-Sylvester P, Mac Laughlin M, Amorena C (2001) Peritubular fluid viscosity modulates H+ flux in proximal tubules through NO release. Am J Physiol Ren Physiol 280:F239–F243

    Google Scholar 

  71. Dobrowolski L, Walkowska A, Kompanowska-Jezierska E, Kuczeriszka M, Sadowski J (2007) Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450. Acta Physiol (Oxf) 189:77–85

    CAS  Google Scholar 

  72. Du J, Zhang L, Yang Y, Li W, Chen L, Ge Y, Sun C, Zhu Y, Gu L (2010) ATP depletion-induced actin rearrangement reduces cell adhesion via p38 MAPK–HSP27 signaling in renal proximal tubule cells. Cell Physiol Biochem 25:501–510

    PubMed  CAS  Google Scholar 

  73. Dubey RK, Gillespie DG, Mi Z, Jackson EK (2005) Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A2B receptors. Hypertension 46:628–634

    PubMed  CAS  Google Scholar 

  74. Ecelbarger CA, Maeda Y, Gibson CC, Knepper MA (1994) Extracellular ATP increases intracellular calcium in rat terminal collecting duct via a nucleotide receptor. Am J Physiol 267:F998–F1006

    PubMed  CAS  Google Scholar 

  75. Edgecombe M, Craddock HS, Smith DC, McLennan AG, Fisher MJ (1997) Diadenosine polyphosphate-stimulated gluconeogenesis in isolated rat proximal tubules. Biochem J 323(Pt 2):451–456

    PubMed Central  PubMed  CAS  Google Scholar 

  76. Edwards RM (2002) Basolateral, but not apical, ATP inhibits vasopressin action in rat inner medullary collecting duct. Eur J Pharmacol 438:179–181

    PubMed  CAS  Google Scholar 

  77. Eladari D, Chambrey R, Peti-Peterdi J (2012) A new look at electrolyte transport in the distal tubule. Annu Rev Physiol 74:325–349

    PubMed  CAS  Google Scholar 

  78. Elsherbiny NM, Abd El Galil KH, Gabr MM, Al-Gayyar MM, Eissa LA, El-Shishtawy MM (2012) Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw 23:78–86

    PubMed  CAS  Google Scholar 

  79. Eltze M, Ullrich B (1996) Characterization of vascular P2 purinoceptors in the rat isolated perfused kidney. Eur J Pharmacol 306:139–152

    PubMed  CAS  Google Scholar 

  80. Elwi AN, Damaraju VL, Kuzma ML, Mowles DA, Baldwin SA, Young JD, Sawyer MB, Cass CE (2009) Transepithelial fluxes of adenosine and 2′-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3. Am J Physiol Ren Physiol 296:F1439–F1451

    CAS  Google Scholar 

  81. Enjyoji K, Sevigny J, Lin Y, Frenette PS, Christie PD, Esch JS, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD (1999) Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med 5:1010–1017

    PubMed  CAS  Google Scholar 

  82. Eppel GA, Ventura S, Evans RG (2006) Regional vascular responses to ATP and ATP analogues in the rabbit kidney in vivo: roles for adenosine receptors and prostanoids. Br J Pharmacol 149:523–531

    PubMed Central  PubMed  CAS  Google Scholar 

  83. Faulhaber-Walter R, Chen L, Oppermann M, Kim SM, Huang Y, Hiramatsu N, Mizel D, Kajiyama H, Zerfas P, Briggs JP, Kopp JB, Schnermann J (2008) Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury. J Am Soc Nephrol 19:722–730

    PubMed Central  PubMed  CAS  Google Scholar 

  84. Feng MG, Navar LG (2010) Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Ren Physiol 299:F310–F315

    CAS  Google Scholar 

  85. Ferenbach DA, Hughes J (2011) Adenosine A2A agonists as therapy for glomerulonephritis. Kidney Int 80:329–331

    PubMed  CAS  Google Scholar 

  86. Fernandez O, Wangensteen R, Osuna A, Vargas F (2000) Renal vascular reactivity to P2-purinoceptor activation in spontaneously hypertensive rats. Pharmacology 60:47–50

    PubMed  CAS  Google Scholar 

  87. Fischer KG, Saueressig U, Jacobshagen C, Wichelmann A, Pavenstädt H (2001) Extracellular nucleotides regulate cellular functions of podocytes in culture. Am J Physiol Ren Physiol 281:F1075–F1081

    CAS  Google Scholar 

  88. Fischer W, Wirkner K, Weber M, Eberts C, Köles L, Reinhardt R, Franke H, Allgaier C, Gillen C, Illes P (2003) Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol. J Neurochem 85:779–790

    PubMed  CAS  Google Scholar 

  89. Fischer W, Franke H, Gröger-Arndt H, Illes P (2005) Evidence for the existence of P2Y1,2,4 receptor subtypes in HEK-293 cells: reactivation of P2Y1 receptors after repetitive agonist application. Naunyn Schmiedebergs Arch Pharmacol 371:466–472

    PubMed  CAS  Google Scholar 

  90. Fish RS, Klootwijk E, Tam FW, Kleta R, Wheeler DC, Unwin RJ, Norman J (2013) ATP and arterial calcification. Eur J Clin Investig 43:405–412

    CAS  Google Scholar 

  91. Franco M, Bell PD, Navar LG (1989) Effect of adenosine A1 analogue on tubuloglomerular feedback mechanism. Am J Physiol 257:F231–F236

    PubMed  CAS  Google Scholar 

  92. Franco M, Galicia O, Quintana A, Martínez F (2004) Experimental hypothyroidism modifies specific binding of A1 and A2A analogues to adenosine receptors in the rat kidney. Br J Pharmacol 142:461–468

    PubMed Central  PubMed  CAS  Google Scholar 

  93. Franco M, Bautista R, Perez-Mendez O, Gonzalez L, Pacheco U, Sanchez-Lozada LG, Santamaria J, Tapia E, Monreal R, Martinez F (2008) Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats. Am J Physiol Ren Physiol 294:F84–F92

    CAS  Google Scholar 

  94. Franco M, Bautista R, Tapia E, Soto V, Santamaría J, Osorio H, Pacheco U, Sánchez-Lozada LG, Kobori H, Navar LG (2011) Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats. Am J Physiol Ren Physiol 300:F1301–F1309

    CAS  Google Scholar 

  95. Friedrich F, Weiss H, Paulmichl M, Lang F (1989) Activation of potassium channels in renal epithelioid cells (MDCK) by extracellular ATP. Am J Physiol 256:C1016–C1021

    PubMed  CAS  Google Scholar 

  96. Fürstenau CR, Ramos DB, Vuaden FC, Casali EA, PdS M, DdS T, Gossenheimer AN, Bogo MR, Bonan CD, Barreto-Chaves ML, Sarkis JJ, Wofchuk ST (2010) L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats. Life Sci 87:325–332

    PubMed  Google Scholar 

  97. Gaál K, Forgács I, Bácsalmásy Z (1976) Effect of adenosine compounds (ATP, cAMP) on renin release in vitro. Acta Physiol Acad Sci Hung 47:49–54

    PubMed  Google Scholar 

  98. Gandhi R, Le Hir M, Kaissling B (1990) Immunolocalization of ecto-5′-nucleotidase in the kidney by a monoclonal antibody. Histochemistry 95:165–174

    PubMed  CAS  Google Scholar 

  99. Gao X, Patzak A, Sendeski M, Scheffer PG, Teerlink T, Sällstrom J, Fredholm BB, Persson AE, Carlström M (2011) Adenosine A1-receptor deficiency diminishes afferent arteriolar and blood pressure responses during nitric oxide inhibition and angiotensin II treatment. Am J Physiol Regul Integr Comp Physiol 301:R1669–R1681

    PubMed  CAS  Google Scholar 

  100. Garcia GE, Truong LD, Li P, Zhang P, Du J, Chen JF, Feng L (2008) Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J 22:445–454

    PubMed Central  PubMed  CAS  Google Scholar 

  101. Garcia GE, Truong LD, Chen JF, Johnson RJ, Feng L (2011) Adenosine A2A receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney Int 80:378–388

    PubMed  CAS  Google Scholar 

  102. Garvin JL, Hong NJ (1999) Nitric oxide inhibits sodium/hydrogen exchange activity in the thick ascending limb. Am J Physiol 277:F377–F382

    PubMed  CAS  Google Scholar 

  103. Garvin JL, Herrera M, Ortiz PA (2011) Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications. Annu Rev Physiol 73:359–376

    PubMed  CAS  Google Scholar 

  104. Garvin PJ, Jellinek M, Morgan R, Codd JE (1981) Renal cortical levels of adenosine triphosphate: restoration after prolonged ischemia by in situ perfusion of ATP-MgCl2. Arch Surg 116:221–224

    PubMed  CAS  Google Scholar 

  105. Geyti CS, Odgaard E, Overgaard MT, Jensen ME, Leipziger J, Praetorius HA (2008) Slow spontaneous [Ca2+]i oscillations reflect nucleotide release from renal epithelia. Pflugers Arch 455:1105–1117

    PubMed  CAS  Google Scholar 

  106. Gheorghiu M, Van Driessche W (2004) Modeling of basolateral ATP release induced by hypotonic treatment in A6 cells. Eur Biophys J 33:412–420

    PubMed  CAS  Google Scholar 

  107. Gill A, Wortham K, Costa D, Davis W, Ticho B, Whalley E (2009) Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against cisplatin-induced acute kidney injury in rats. Am J Nephrol 30:521–526

    PubMed  CAS  Google Scholar 

  108. Goel M, Schilling WP (2010) Role of TRPC3 channels in ATP-induced Ca2+ signaling in principal cells of the inner medullary collecting duct. Am J Physiol Ren Physiol 299:F225–F233

    CAS  Google Scholar 

  109. Gomes CP, Leão-Ferreira LR, Pinheiro AA, Gomes-Quintana E, Wengert M, Lopes AG, Caruso-Neves C (2008) Crosstalk between the signaling pathways triggered by angiotensin II and adenosine in the renal proximal tubules: implications for modulation of Na+-ATPase activity. Peptides 29:2033–2038

    PubMed  CAS  Google Scholar 

  110. Gopalakrishnan S, Raman N, Atkinson SJ, Marrs JA (1998) Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. Am J Physiol 275:C798–C809

    PubMed  CAS  Google Scholar 

  111. Gopalakrishnan S, Hallett MA, Atkinson SJ, Marrs JA (2007) aPKC–PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion. Am J Physiol Cell Physiol 292:C1094–C1102

    PubMed  CAS  Google Scholar 

  112. Gorelik J, Zhang Y, Sánchez D, Shevchuk A, Frolenkov G, Lab M, Klenerman D, Edwards C, Korchev Y (2005) Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. Proc Natl Acad Sci U S A 102:15000–15005

    PubMed Central  PubMed  CAS  Google Scholar 

  113. Gottlieb SS (2001) Are all beta-blockers the same for chronic heart failure? Curr Cardiol Rep 3:124–129

    PubMed  CAS  Google Scholar 

  114. Graciano ML, Nishiyama A, Jackson K, Seth DM, Ortiz RM, Prieto-Carrasquero MC, Kobori H, Navar LG (2008) Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. Am J Physiol Ren Physiol 294:F161–F169

    CAS  Google Scholar 

  115. Greiber S, Münzel T, Kästner S, Müller B, Schollmeyer P, Pavenstädt H (1998) NAD(P)H oxidase activity in cultured human podocytes: effects of adenosine triphosphate. Kidney Int 53:654–663

    PubMed  CAS  Google Scholar 

  116. Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET (2012) Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release. J Immunol 189:4566–4573

    PubMed Central  PubMed  CAS  Google Scholar 

  117. Guan Z, Inscho EW (2011) Role of adenosine 5′-triphosphate in regulating renal microvascular function and in hypertension. Hypertension 58:333–340

    PubMed Central  PubMed  CAS  Google Scholar 

  118. Guan Z, Osmond DA, Inscho EW (2007) Purinoceptors in the kidney. Exp Biol Med (Maywood) 232:715–726

    CAS  Google Scholar 

  119. Guan Z, Fuller BS, Yamamoto T, Cook AK, Pollock JS, Inscho EW (2010) Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X1 receptor activation. Am J Physiol Ren Physiol 298:F1276–F1284

    CAS  Google Scholar 

  120. Guerra L, Favia M, Fanelli T, Calamita G, Svetlo M, Bagorda A, Jacobson KA, Reshkin SJ, Casavola V (2004) Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells. Pflugers Arch 449:66–75

    PubMed  CAS  Google Scholar 

  121. Gutierrez AM, Lou X, Erik A, Persson G, Ring A (1999) Ca2+ response of rat mesangial cells to ATP analogues. Eur J Pharmacol 369:107–112

    PubMed  CAS  Google Scholar 

  122. Gutierrez AM, Lou X, Erik A, Persson G, Ring A (2000) Growth hormones reverse desensitization of P2Y2 receptors in rat mesangial cells. Biochem Biophys Res Commun 270:594–599

    PubMed  CAS  Google Scholar 

  123. Hanner F, Sorensen CM, Holstein-Rathlou NH, Peti-Peterdi J (2010) Connexins and the kidney. Am J Physiol Regul Integr Comp Physiol 298:R1143–R1155

    PubMed Central  PubMed  CAS  Google Scholar 

  124. Hanner F, Lam L, Nguyen MT, Yu A, Peti-Peterdi J (2012) Intrarenal localization of the plasma membrane ATP channel pannexin1. Am J Physiol Ren Physiol 303:F1454–F1459

    CAS  Google Scholar 

  125. Harada H, Tsukimoto M, Ikari A, Suketa Y (2003) P2X7 receptor-induced generation of reactive oxygen species in rat mesangial cells. Drug Dev Res 59:112–117

    CAS  Google Scholar 

  126. Harahap AR, Goding JW (1988) Distribution of the murine plasma cell antigen PC-1 in non-lymphoid tissues. J Immunol 141:2317–2320

    PubMed  CAS  Google Scholar 

  127. Harhun M, Povstyan O, Gordienko D (2009) P2X receptor-mediated current in myocytes from renal resistance arteries. J Gen Physiol 134:7a

    Google Scholar 

  128. Heidemann HT, Müller S, Mertins L, Stepan G, Hoffmann K, Ohnhaus EE (1989) Effect of aminophylline on cisplatin nephrotoxicity in the rat. Br J Pharmacol 97:313–318

    PubMed Central  PubMed  CAS  Google Scholar 

  129. Heidenreich S, Tepel M, Schlüter H, Harrach B, Zidek W (1995) Regulation of rat mesangial cell growth by diadenosine phosphates. J Clin Invest 95:2862–2867

    PubMed Central  PubMed  CAS  Google Scholar 

  130. Heyeraas KJ, Aukland K (1987) Interlobular arterial resistance: influence of renal arterial pressure and angiotensin II. Kidney Int 31:1291–1298

    PubMed  CAS  Google Scholar 

  131. Hill C, Parker AJ, White SJ (2000) Expression of P2X purinergic receptors in cultured mouse mesangial cells. J Physiol 527:15P–16P

    Google Scholar 

  132. Hillman KA, Johnson TM, Winyard PJD, Burnstock G, Unwin RJ, Woolf AS (2002) P2X7 receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Exp Nephrol 10:34–42

    PubMed  CAS  Google Scholar 

  133. Hillman KA, Woolf AS, Johnson TM, Wade A, Unwin RJ, Winyard PJ (2004) The P2X7 ATP receptor modulates renal cyst development in vitro. Biochem Biophys Res Commun 322:434–439

    PubMed  CAS  Google Scholar 

  134. Hohenstein B, Renk S, Lang K, Daniel C, Freund M, Léon C, Amann KU, Gachet C, Hugo CP (2007) P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis. J Am Soc Nephrol 18:494–505

    PubMed  CAS  Google Scholar 

  135. Holstein-Rathlou NH (1987) Synchronization of proximal intratubular pressure oscillations: evidence for interaction between nephrons. Pflugers Arch 408:438–443

    PubMed  CAS  Google Scholar 

  136. Holtzclaw JD, Cornelius RJ, Hatcher LI, Sansom SC (2011) Coupled ATP and potassium efflux from intercalated cells. Am J Physiol Ren Physiol 300:F1319–F1326

    CAS  Google Scholar 

  137. Hooper KM, Boletta A, Germino GG, Hu Q, Ziegelstein RC, Sutters M (2005) Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells. Am J Physiol Ren Physiol 289:F521–F530

    CAS  Google Scholar 

  138. Hovater MB, Olteanu D, Yoder BK, Schwiebert EM (2007) Autocrine purinergic signaling is required for monocilium-driven signaling. FASEB J 21:596.1

    Google Scholar 

  139. Hovater MB, Olteanu D, Welty EA, Schwiebert EM (2008) Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts. Purinergic Signal 4:109–124

    PubMed Central  PubMed  CAS  Google Scholar 

  140. Hovater MB, Olteanu D, Hanson EL, Cheng NL, Siroky B, Fintha A, Komlosi P, Liu W, Satlin LM, Bell PD, Yoder BK, Schwiebert EM (2008) Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal 4:155–170

    PubMed Central  PubMed  CAS  Google Scholar 

  141. Hu J, Barr MM (2005) ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling. Mol Biol Cell 16:458–469

    PubMed Central  PubMed  CAS  Google Scholar 

  142. Hughes RJ, Torres B, Zambon A, Arthur D, Bohmann C, Rump LC, Insel PA (2003) Expression of multiple P2Y receptors by MDCK-D1 cells: P2Y1 receptor cloning and signaling. Drug Dev Res 59:1–7

    CAS  Google Scholar 

  143. Huwiler A, Pfeilschifter J (1994) Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells. Br J Pharmacol 113:1455–1463

    PubMed Central  PubMed  CAS  Google Scholar 

  144. Huwiler A, Wartmann M, van den Bosch H, Pfeilschifter J (2000) Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells. Br J Pharmacol 129:612–618

    PubMed Central  PubMed  CAS  Google Scholar 

  145. Huwiler A, Rölz W, Dorsch S, Ren S, Pfeilschifter J (2002) Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y2 purinoceptor in renal mesangial cells. Br J Pharmacol 136:520–529

    PubMed Central  PubMed  CAS  Google Scholar 

  146. Inscho EW (2001) P2 receptors in regulation of renal microvascular function. Am J Physiol Ren Physiol 280:F927–F944

    CAS  Google Scholar 

  147. Inscho EW (2009) Purinoceptor regulation of renal tubular transport is coming of age. Am J Physiol Ren Physiol 297:F1166–F1167

    CAS  Google Scholar 

  148. Inscho EW (2009) Lewis K. Dahl Memorial Lecture. Mysteries of renal autoregulation. Hypertension 53:299–306

    PubMed Central  PubMed  CAS  Google Scholar 

  149. Inscho EW, Ohishi K, Navar LG (1992) Effects of ATP on pre- and postglomerular juxtamedullary microvasculature. Am J Physiol 263:F886–F893

    PubMed  CAS  Google Scholar 

  150. Inscho EW, Mitchell KD, Navar LG (1994) Extracellular ATP in the regulation of renal microvascular function. FASEB J 8:319–328

    PubMed  CAS  Google Scholar 

  151. Inscho EW, Cook AK, Navar LG (1996) Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activation. Am J Physiol 271:F1077–F1085

    PubMed  CAS  Google Scholar 

  152. Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ (2003) Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112:1895–1905

    PubMed Central  PubMed  CAS  Google Scholar 

  153. Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ (2004) Renal autoregulation in P2X1 knockout mice. Acta Physiol Scand 181:445–453

    PubMed  CAS  Google Scholar 

  154. Inscho EW, Cook AK, Clarke A, Zhang S, Guan Z (2011) P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt diet. Hypertension 57:780–787

    PubMed Central  PubMed  CAS  Google Scholar 

  155. Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, Post SR (2001) P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clin Exp Pharmacol Physiol 28:351–354

    PubMed  CAS  Google Scholar 

  156. Ishikawa I, Shikura N, Takada K (1993) Amelioration of glycerol-induced acute renal failure in rats by an adenosine A1 receptor antagonist (FR-113453). Ren Fail 15:1–5

    PubMed  CAS  Google Scholar 

  157. Ishikawa S, Kawasumi M, Kusaka I, Komatsu N, Iwao N, Saito T (1994) Extracellular ATP promotes cellular growth of glomerular mesangial cells mediated via phospholipase C. Biochem Biophys Res Commun 202:234–240

    PubMed  CAS  Google Scholar 

  158. Itoh S, Carretero OA, Murray RD (1985) Possible role of adenosine in the macula densa mechanism of renin release in rabbits. J Clin Invest 76:1412–1417

    PubMed Central  PubMed  CAS  Google Scholar 

  159. Jackson EK (1991) Adenosine: a physiological brake on renin release. Annu Rev Pharmacol Toxicol 31:1–35

    PubMed  CAS  Google Scholar 

  160. Jackson EK (1997) Renal actions of purines. In: Jacobson KA, Jarvis MF (eds) Purinergic approaches in experimental therapeutics. Wiley-Liss, New York, pp 217–250

    Google Scholar 

  161. Jackson EK (2001) P1 and P2 receptors in the renal system. In: Abbracchio MP, Williams M (eds) Purinergic and pyrimidinergic signalling II. Springer, Berlin, pp 33–71

    Google Scholar 

  162. Jackson EK, Cheng D, Tofovic SP, Mi Z (2012) Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1 receptor-mediated coincident signaling. Am J Physiol Ren Physiol 302:F466–F476

    CAS  Google Scholar 

  163. Jalilian I, Spildrejorde M, Seavers A, Curtis BL, McArthur JD, Sluyter R (2012) Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells. Vet Immunol Immunopathol 150:228–233

    PubMed  CAS  Google Scholar 

  164. Jan CR, Ho CM, Wu SN, Tseng CJ (1998) Mechanisms of rise and decay of ADP-evoked calcium signal in MDCK cells. Chin J Physiol 41:67–73

    PubMed  CAS  Google Scholar 

  165. Jankowski M (2008) Purinergic regulation of glomerular microvasculature and tubular function. J Physiol Pharmacol 59(Suppl 9):121–135

    PubMed  Google Scholar 

  166. Jankowski M, Szczepanska-Konkel M, Kalinowski L, Angielski S (2001) Cyclic GMP-dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP. J Physiol 530:123–130

    PubMed Central  PubMed  CAS  Google Scholar 

  167. Jankowski M, Angielski S, Szczepanska-Konkel M (2008) Dissociation between the effects of P1, P4-diadenosine tetraphosphate (Ap4A) on renal haemodynamics and tubular function in anaesthetized rats. J Physiol Pharmacol 59:129–137

    PubMed  CAS  Google Scholar 

  168. Jankowski M, Szamocka E, Kowalski R, Angielski S, Szczepanska-Konkel M (2011) The effects of P2X receptor agonists on renal sodium and water excretion in anaesthetized rats. Acta Physiol (Oxf) 202:193–201

    CAS  Google Scholar 

  169. Jankowski V, Karadogan S, Vanholder R, Nofer JR, Herget-Rosenthal S, van der Giet M, Tölle M, Tran TN, Zidek W, Jankowski J (2007) Paracrine stimulation of vascular smooth muscle proliferation by diadenosine polyphosphates released from proximal tubule epithelial cells. Kidney Int 71:994–1000

    PubMed  CAS  Google Scholar 

  170. Jankowski V, Patzak A, Herget-Rosenthal S, Tran TN, Lai EY, Gunthner T, Buschmann I, Zidek W, Jankowski J (2008) Uridine adenosine tetraphosphate acts as an autocrine hormone affecting glomerular filtration rate. J Mol Med 86:333–340

    PubMed  CAS  Google Scholar 

  171. Jankowski V, Günthner T, Herget-Rosenthal S, Zidek W, Jankowski J (2009) Dinucleoside polyphosphates and uremia. Semin Dial 22:396–399

    PubMed  Google Scholar 

  172. Jans D, Srinivas SP, Waelkens E, Segal A, Larivière E, Simaels J, Van Driessche W (2002) Hypotonic treatment evokes biphasic ATP release across the basolateral membrane of cultured renal epithelia (A6). J Physiol 545:543–555

    PubMed Central  PubMed  CAS  Google Scholar 

  173. Jaramillo-Juárez F, Rodríguez-Vázquez ML, Muñoz-Martínez J, Quezada-Tristán T, Posadas del Río FA, Llamas-Viramontes J, Ortíz GG, Feria-Velasco A, Reyes JL (2005) The ATP levels in kidneys and blood are mainly decreased by acute ingestion of tullidora (Karwinskia humboldtiana). Toxicon 46:99–103

    PubMed  Google Scholar 

  174. Jensen ME, Odgaard E, Christensen MH, Praetorius HA, Leipziger J (2007) Flow-induced [Ca2+]i increase depends on nucleotide release and subsequent purinergic signaling in the intact nephron. J Am Soc Nephrol 18:2062–2070

    PubMed  CAS  Google Scholar 

  175. Jeyaraj SC, Dakhlallah D, Hill SR, Lee BS (2006) Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells. Am J Physiol Ren Physiol 291:F1255–F1263

    CAS  Google Scholar 

  176. Ji X, Naito Y, Hirokawa G, Weng H, Hiura Y, Takahashi R, Iwai N (2012) P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats. Hypertens Res 35:173–179

    PubMed  CAS  Google Scholar 

  177. Jian R, Sun Y, Wang Y, Yu J, Zhong L, Zhou P (2012) CD73 protects kidney from ischemia–reperfusion injury through reduction of free radicals. APMIS 120:130–138

    PubMed  CAS  Google Scholar 

  178. Jin W, Hopfer U (1997) Purinergic-mediated inhibition of Na+-K+-ATPase in proximal tubule cells: elevated cytosolic Ca2+ is not required. Am J Physiol 272:C1169–C1177

    PubMed  CAS  Google Scholar 

  179. Joseph SM, Buchakjian MR, Dubyak GR (2003) Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem 278:23331–23342

    PubMed  CAS  Google Scholar 

  180. Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, Jankowski M, Martyniec L, Angielski S, Malinski T (2003) Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action. Circulation 107:2747–2752

    PubMed  CAS  Google Scholar 

  181. Kang HS, Kerstan D, Dai LJ, Ritchie G, Quamme GA (2001) Adenosine modulates Mg2+ uptake in distal convoluted tubule cells via A1 and A2 purinoceptors. Am J Physiol Ren Physiol 281:F1141–F1147

    CAS  Google Scholar 

  182. Karczewska J, Piwkowska A, Rogacka D, Stepinski J, Angielski S, Jankowski M (2011) Purinergic modulation of glucose uptake into cultured rat podocytes: effect of diabetic milieu. Biochem Biophys Res Commun 404:723–727

    PubMed  CAS  Google Scholar 

  183. Kauffenstein G, Drouin A, Thorin-Trescases N, Bachelard H, Robaye B, Orleans-Juste P, Marceau F, Thorin E, Sevigny J (2010) NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse. Cardiovasc Res 85:204–213

    PubMed Central  PubMed  CAS  Google Scholar 

  184. Kawabata M, Ogawa T, Takabatake T (1998) Control of rat glomerular microcirculation by juxtaglomerular adenosine A1 receptors. Kidney Int Suppl 67:S228–S230

    PubMed  CAS  Google Scholar 

  185. Kempson SA, Edwards JM, Osborn A, Sturek M (2008) Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells. Am J Physiol Ren Physiol 295:F108–F117

    CAS  Google Scholar 

  186. Kim YH, Choi YJ, Bae HR, Woo JS (2009) P2 Receptor-mediated inhibition of vasopressin-stimulated fluid transport and cAMP responses in AQP2-transfected MDCK cells. Korean J Physiol Pharmacol 13:9–14

    PubMed Central  PubMed  CAS  Google Scholar 

  187. Kishore BK, Chou CL, Knepper MA (1995) Extracellular nucleotide receptor inhibits AVP-stimulated water permeability in inner medullary collecting duct. Am J Physiol 269:F863–F869

    PubMed  CAS  Google Scholar 

  188. Kishore BK, Ginns SM, Krane CM, Nielsen S, Knepper MA (2000) Cellular localization of P2Y2 purinoceptor in rat renal inner medulla and lung. Am J Physiol Ren Physiol 278:F43–F51

    CAS  Google Scholar 

  189. Kishore BK, Kran CM, Reif M, Menon AG (2001) Molecular physiology of urinary concentration defect in elderly population. Int Urol Nephrol 33:235–248

    Google Scholar 

  190. Kishore BK, Isaac J, Fausther M, Tripp SR, Shi H, Gill PS, Braun N, Zimmermann H, Sévigny J, Robson SC (2005) Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Am J Physiol Ren Physiol 288:F1032–F1043

    CAS  Google Scholar 

  191. Kishore BK, Krane CM, Miller RL, Shi H, Zhang P, Hemmert A, Sun R, Nelson RD (2005) P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Am J Physiol Ren Physiol 288:F1164–F1172

    CAS  Google Scholar 

  192. Kishore BK, Nelson RD, Miller RL, Carlson NG, Kohan DE (2009) P2Y2 receptors and water transport in the kidney. Purinergic Signal 5:491–499

    PubMed Central  PubMed  CAS  Google Scholar 

  193. Klawitter S, Hofmann LP, Pfeilschifter J, Huwiler A (2007) Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Br J Pharmacol 150:271–280

    PubMed Central  PubMed  CAS  Google Scholar 

  194. Kleta R, Hirsch J, Heidenreich S, Schlüter H, Zidek W, Schlatter E (1995) Effects of diadenosine polyphosphates, ATP and angiotensin II on membrane voltage and membrane conductances of rat mesangial cells. Pflugers Arch 430:713–720

    PubMed  CAS  Google Scholar 

  195. Koltsova SV, Platonova A, Maksimov GV, Mongin AA, Grygorczyk R, Orlov SN (2011) Activation of P2Y receptors causes strong and persistent shrinkage of C11-MDCK renal epithelial cells. Am J Physiol Cell Physiol 301:C403–C412

    PubMed Central  PubMed  CAS  Google Scholar 

  196. Komlosi P, Peti-Peterdi J, Fuson AL, Fintha A, Rosivall L, Bell PD (2004) Macula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake. Am J Physiol Renal Physiol 286:F1054–F1058

    PubMed  CAS  Google Scholar 

  197. Koster HP, Hartog A, van Os CH, Bindels RJ (1996) Inhibition of Na+ and Ca2+ reabsorption by P2u purinoceptors requires PKC but not Ca2+ signaling. Am J Physiol 270:F53–F60

    PubMed  CAS  Google Scholar 

  198. Kottgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182:437–447

    PubMed Central  PubMed  Google Scholar 

  199. Kowalski R, Kreft E, Kasztan M, Jankowski M, Szczepanska-Konkel M (2012) Chronic renal denervation increases renal tubular response to P2X receptor agonists in rats: implication for renal sympathetic nerve ablation. Nephrol Dial Transplant 27:3443–3448

    PubMed  CAS  Google Scholar 

  200. Kriz W (2004) Adenosine and ATP: traffic regulators in the kidney. J Clin Invest 114:611–613

    PubMed Central  PubMed  CAS  Google Scholar 

  201. Kuczeriszka M, Dobrowolski L, Walkowska A, Sadowski J, Kompanowska-Jezierska E (2013) Adenosine effects on renal function in the rat: role of sodium intake and cytochrome P450. Nephron Physiol 123:1–5

    PubMed  Google Scholar 

  202. Kulick A, Panico C, Gill P, Welch WJ (2008) Low salt intake increases adenosine type 1 receptor expression and function in the rat proximal tubule. Am J Physiol Ren Physiol 295:F37–F41

    CAS  Google Scholar 

  203. Kurtz A, Kaissling B, Busse R, Baier W (1991) Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells. J Clin Invest 88:1147–1154

    PubMed Central  PubMed  CAS  Google Scholar 

  204. Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168:6436–6445

    PubMed  CAS  Google Scholar 

  205. Lajdova I, Oksa A, Chorvat D Jr, Topor P, Spustova V (2012) Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease. Kidney Blood Press Res 35:48–57

    PubMed  CAS  Google Scholar 

  206. Lang F, Plöckinger B, Häussinger D, Paulmichl M (1988) Effects of extracellular nucleotides on electrical properties of subconfluent Madin Darby canine kidney cells. Biochim Biophys Acta 943:471–476

    PubMed  CAS  Google Scholar 

  207. Le Hir M, Gandhi R, Dubach UC (1989) Purification and properties of a 5′-nucleotidase from rat renal membranes. Enzyme 41:87–93

    PubMed  Google Scholar 

  208. Lee HT, Ota-Setlik A, Xu H, D’Agati VD, Jacobson MA, Emala CW (2003) A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure. Am J Physiol Ren Physiol 284:F267–F273

    CAS  Google Scholar 

  209. Lee SJ, Kwon CH, Kim YK (2009) Alterations in membrane transport function and cell viability induced by ATP depletion in primary cultured rabbit renal proximal tubular cells. Korean J Physiol Pharmacol 13:15–22

    PubMed Central  PubMed  CAS  Google Scholar 

  210. Lee YJ, Park SH, Han HJ (2005) ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells. Am J Physiol Cell Physiol 289:C1268–C1276

    PubMed  CAS  Google Scholar 

  211. Lee YJ, Park SH, Jeung TO, Kim KW, Lee JH, Han HJ (2005) Effect of adenosine triphosphate on phosphate uptake in renal proximal tubule cells: involvement of PKC and p38 MAPK. J Cell Physiol 205:68–76

    PubMed  CAS  Google Scholar 

  212. Lee YJ, Han HJ (2006) Role of ATP in DNA synthesis of renal proximal tubule cells: involvement of calcium, MAPKs, and CDKs. Am J Physiol Ren Physiol 291:F98–F106

    CAS  Google Scholar 

  213. Lee YJ, Lee JH, Han HJ (2006) Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21WAF1/Cip1 and p27Kip1 expression in primary cultured renal proximal tubule cells: role of PI3K and Akt signaling. J Cell Physiol 209:802–810

    PubMed  CAS  Google Scholar 

  214. Lehrmann H, Thomas J, Kim SJ, Jacobi C, Leipziger J (2002) Luminal P2Y2 receptor-mediated inhibition of Na+ absorption in isolated perfused mouse CCD. J Am Soc Nephrol 13:10–18

    PubMed  CAS  Google Scholar 

  215. Leipziger J (2003) Control of epithelial transport via luminal P2 receptors. Am J Physiol Ren Physiol 284:F419–F432

    CAS  Google Scholar 

  216. Leipziger J (2011) Luminal nucleotides are tonic inhibitors of renal tubular transport. Curr Opin Nephrol Hypertens 20:518–522

    PubMed  CAS  Google Scholar 

  217. Leipziger J, Bailey MA, Unwin RJ (2003) Purinergic (P2) receptors in the Kidney. Curr Top Membr 54:36–394

    Google Scholar 

  218. Lewis CJ, Evans RJ (2001) P2X receptor immunoreactivity in different arteries from the femoral, pulmonary, cerebral, coronary and renal circulations. J Vasc Res 38:332–340

    PubMed  CAS  Google Scholar 

  219. Li L, Jeanette Lynch I, Zheng W, Cash MN, Teng X, Wingo CS, Verlander JW, Xia SL (2007) Apical P2XR contribute to [Ca2+]i signaling and I sc in mouse renal MCD. Biochem Biophys Res Commun 359:438–444

    PubMed  CAS  Google Scholar 

  220. Li L, Wingo CS, Xia SL (2007) Downregulation of SGK1 by nucleotides in renal tubular epithelial cells. Am J Physiol Ren Physiol 293:F1751–F1757

    CAS  Google Scholar 

  221. Li L, Huang L, Ye H, Song SP, Bajwa A, Lee SJ, Moser EK, Jaworska K, Kinsey GR, Day YJ, Linden J, Lobo PI, Rosin DL, Okusa MD (2012) Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury. J Clin Invest 122:3931–3942

    PubMed Central  PubMed  CAS  Google Scholar 

  222. Li L, Lai EY, Huang Y, Eisner C, Mizel D, Wilcox CS, Schnermann J (2012) Renal afferent arteriolar and tubuloglomerular feedback reactivity in mice with conditional deletions of adenosine 1 receptors. Am J Physiol Ren Physiol 303:F1166–F1175

    CAS  Google Scholar 

  223. Liclican EL, McGiff JC, Pedraza PL, Ferreri NR, Falck JR, Carroll MA (2005) Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids. Am J Physiol Ren Physiol 289:F386–F392

    CAS  Google Scholar 

  224. Lieberthal W, Menza SA, Levine JS (1998) Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells. Am J Physiol 274:F315–F327

    PubMed  CAS  Google Scholar 

  225. Listhrop R, Nelson R, Ecelbarger CA, Kohan DE, Kishore B (2007) Genetic deletion of P2Y2 receptor (P2Y2-R) alters the protein abundances of renal sodium transporters and channels. FASEB J 21:A1328

    Google Scholar 

  226. Liu R, Persson AE (2002) Effects of nitric oxide on P2Y receptor resensitization in spontaneously hypertensive rat mesangial cells. J Hypertens 20:1835–1842

    PubMed  CAS  Google Scholar 

  227. Liu R, Gutierrez AM, Ring A, Persson AE (2002) Nitric oxide induces resensitization of P2Y nucleotide receptors in cultured rat mesangial cells. J Am Soc Nephrol 13:313–321

    PubMed  Google Scholar 

  228. Liu ZX, Nickel CH, Cantley LG (2001) HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. Am J Physiol Ren Physiol 281:F62–F70

    CAS  Google Scholar 

  229. Locovei S, Wang J, Dahl G (2006) Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett 580:239–244

    PubMed  CAS  Google Scholar 

  230. Loesch A, Unwin R, Gandhi V, Burnstock G (2009) Sympathetic nerve varicosities in close apposition with basolateral membranes of collecting duct epithelial cells of rat kidney. Nephron Physiol 113:15–21

    Google Scholar 

  231. Lu Y, Ge Y, Manning RD Jr (2011) Expression and function of adenosine A3 receptor in the afferent arteriole. Hypertens 58:E139

    Google Scholar 

  232. Ma HP, Li L, Zhou ZH, Eaton DC, Warnock DG (2002) ATP masks stretch activation of epithelial sodium channels in A6 distal nephron cells. Am J Physiol Ren Physiol 282:F501–F505

    CAS  Google Scholar 

  233. Ma HP, Chou CF, Wei SP, Eaton DC (2007) Regulation of the epithelial sodium channel by phosphatidylinositides: experiments, implications, and speculations. Pflugers Arch 455:169–180

    PubMed  CAS  Google Scholar 

  234. Macala LJ, Hayslett JP (2002) Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells. Am J Physiol Ren Physiol 283:F1216–F1225

    CAS  Google Scholar 

  235. MacLaughlin M, Martinez-Salgado C, Eleno N, Olivera A, Lopez-Novoa JM (1997) Adenosine activates mesangial cell proliferation. Cell Signal 9:59–63

    PubMed  CAS  Google Scholar 

  236. Mamenko M, Zaika O, Jin M, O’Neil RG, Pochynyuk O (2011) Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron. PLoS One 6:e22824

    PubMed Central  PubMed  CAS  Google Scholar 

  237. Marques RD, de Bruijn PI, Sorensen MV, Bleich M, Praetorius HA, Leipziger J (2012) Basolateral P2X receptors mediate inhibition of NaCl transport in mouse medullary thick ascending limb (mTAL). Am J Physiol Ren Physiol 302:F487–F494

    CAS  Google Scholar 

  238. McCoy DE, Taylor AL, Kudlow BA, Karlson K, Slattery MJ, Schwiebert LM, Schwiebert EM, Stanton BA (1999) Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors. Am J Physiol 277:F552–F559

    PubMed  CAS  Google Scholar 

  239. McCulloch F, Chambrey R, Eladari D, Peti-Peterdi J (2005) Localization of connexin 30 in the luminal membrane of cells in the distal nephron. Am J Physiol Ren Physiol 289:F1304–F1312

    CAS  Google Scholar 

  240. McKinney TD, Hosford MA (1993) ATP-stimulated tetraethylammonium transport by rabbit renal brush border membrane vesicles. J Biol Chem 268:6886–6895

    PubMed  CAS  Google Scholar 

  241. McLaughlin GE, Alva MD, Egea M (2006) Adenosine receptor antagonism in acute tacrolimus toxicity. Nephrol Dial Transplant 21:1961–1965

    PubMed  CAS  Google Scholar 

  242. Menzies RI, Unwin RJ, Dash RK, Beard DA, Cowley AW, Jr., Carlson BE, Mullins JJ, Bailey MA (2013) Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats. Front Physiol 4:305

    Google Scholar 

  243. Middleton JP, Mangel AW, Basavappa S, Fitz JG (1993) Nucleotide receptors regulate membrane ion transport in renal epithelial cells. Am J Physiol 264:F867–F873

    PubMed  CAS  Google Scholar 

  244. Migita K, Lu L, Zhao Y, Honda K, Iwamoto T, Kita S, Katsuragi T (2005) Adenosine induces ATP release via an inositol 1,4,5-trisphosphate signaling pathway in MDCK cells. Biochem Biophys Res Commun 328:1211–1215

    PubMed  CAS  Google Scholar 

  245. Migita K, Zhao Y, Katsuragi T (2007) Mitochondria play an important role in adenosine-induced ATP release from Madin–Darby canine kidney cells. Biochem Pharmacol 73:1676–1682

    PubMed  CAS  Google Scholar 

  246. Mironova E, Peti-Peterdi J, Bugaj V, Stockand JD (2011) Diminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30. J Biol Chem 286:1054–1060

    PubMed Central  PubMed  CAS  Google Scholar 

  247. Mo J, Fisher MJ (2002) Uridine nucleotide-induced stimulation of gluconeogenesis in isolated rat proximal tubules. Naunyn Schmiedebergs Arch Pharmacol 366:151–157

    PubMed  CAS  Google Scholar 

  248. Modlinger PS, Welch WJ (2003) Adenosine A1 receptor antagonists and the kidney. Curr Opin Nephrol Hypertens 12:497–502

    PubMed  CAS  Google Scholar 

  249. Mohaupt MG, Fischer T, Schwöbel J, Sterzel RB, Schulze-Lohoff E (1998) Activation of purinergic P2Y2 receptors inhibits inducible NO synthase in cultured rat mesangial cells. Am J Physiol 275:F103–F110

    PubMed  CAS  Google Scholar 

  250. Mori M, Nishizaki T, Kawahara K, Okada Y (1996) ATP-activated cation conductance in a Xenopus renal epithelial cell line. J Physiol 491:281–290

    PubMed Central  PubMed  CAS  Google Scholar 

  251. Mori M, Hosomi H, Nishizaki T, Kawahara K, Okada Y (1997) Calcium release from intracellular stores evoked by extracellular ATP in a Xenopus renal epithelial cell line. J Physiol 502:365–373

    PubMed Central  PubMed  CAS  Google Scholar 

  252. Murray RD, Churchill PC (1984) Effects of adenosine receptor agonists in the isolated, perfused rat kidney. Am J Physiol 247:H343–H348

    PubMed  CAS  Google Scholar 

  253. Nagashima K, Kusaka H, Sato K, Karasawa A (1994) Effects of KW-3902, a novel adenosine A1-receptor antagonist, on cephaloridine-induced acute renal failure in rats. Jpn J Pharmacol 64:9–17

    PubMed  CAS  Google Scholar 

  254. Nanoff C, Freissmuth M, Tuisl E, Schütz W (1990) P2-, but not P1-purinoceptors mediate formation of 1,4,5-inositol trisphosphate and its metabolites via a pertussis toxin-insensitive pathway in the rat renal cortex. Br J Pharmacol 100:63–68

    PubMed Central  PubMed  CAS  Google Scholar 

  255. Navar LG, Bell PD (2004) Romancing the macula densa at UAB. Kidney Int Suppl S34-S40

  256. Navar LG, Inscho EW, Majid SA, Imig JD, Harrison-Bernard LM, Mitchell KD (1996) Paracrine regulation of the renal microcirculation. Physiol Rev 76:425–536

    PubMed  CAS  Google Scholar 

  257. Nilius B, Sehrer J, Heinke S, Droogmans G (1995) Ca2+ release and activation of K+ and Cl currents by extracellular ATP in distal nephron epithelial cells. Am J Physiol 269:C376–C384

    PubMed  CAS  Google Scholar 

  258. Nishiyama A, Navar LG (2002) ATP mediates tubuloglomerular feedback. Am J Physiol Regul Integr Comp Physiol 283:R273–R275

    PubMed  CAS  Google Scholar 

  259. Nishiyama A, Abe Y (2003) Potential roles of interstitial fluid adenosine in the regulation of renal hemodynamics. Biogenic Amines 17:459–474

    CAS  Google Scholar 

  260. Nishiyama A, Majid DS, Walker M III, Miyatake A, Navar LG (2001) Renal interstitial ATP responses to changes in arterial pressure during alterations in tubuloglomerular feedback activity. Hypertension 37:753–759

    PubMed  CAS  Google Scholar 

  261. Nishiyama A, Rahman M, Inscho EW (2004) Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function. Hypertens Res 27:791–804

    PubMed  CAS  Google Scholar 

  262. Noji T, Sato H, Sano J, Nishikawa S, Kusaka H, Karasawa A (2002) Treatment with an adenosine uptake inhibitor attenuates glomerulonephritis in mice. Eur J Pharmacol 449:293–300

    PubMed  CAS  Google Scholar 

  263. O’Connor PM, Cowley AW Jr (2012) Medullary thick ascending limb buffer vasoconstriction of renal outer-medullary vasa recta in salt-resistant but not salt-sensitive rats. Hypertension 60:965–972

    PubMed Central  PubMed  Google Scholar 

  264. Odgaard E, Praetorius HA, Leipziger J (2009) AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct. J Med Invest 56(Suppl):262–263

    PubMed  Google Scholar 

  265. Olivera A, Lopez-Novoa JM (1992) Effect of adenosine and adenosine analogues on cyclic AMP accumulation in cultured mesangial cells and isolated glomeruli of the rat. Br J Pharmacol 107:341–346

    PubMed Central  PubMed  CAS  Google Scholar 

  266. Olivetti G, Anversa P, Melissari M, Loud AV (1980) Morphometry of the renal corpuscle during postnatal growth and compensatory hypertrophy. Kidney Int 17:438–454

    PubMed  CAS  Google Scholar 

  267. Olteanu D, Hovater MB, Schwiebert EM (2007) Intraluminal autocrine purinergic signaling within cysts: implications for the progression of diseases that involve encapsulated cyst formation. Am J Physiol Ren Physiol 292:F11–F14

    CAS  Google Scholar 

  268. Orth SR, Amann K, Strojek K, Ritz E (2001) Sympathetic overactivity and arterial hypertension in renal failure. Nephrol Dial Transplant 16(Suppl 1):67–69

    PubMed  Google Scholar 

  269. Ortiz PA, Hong NJ, Garvin JL (2001) NO decreases thick ascending limb chloride absorption by reducing Na+–K+–2Cl cotransporter activity. Am J Physiol Ren Physiol 281:F819–F825

    CAS  Google Scholar 

  270. Ortiz PA, Hong NJ, Garvin JL (2004) Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. Am J Physiol Ren Physiol 287:F274–F280

    CAS  Google Scholar 

  271. Ortiz-Capisano MC, Mendez M, Ortiz PA, Beierwaltes WH (2011) Adenosine 1 receptors are expressed by juxtaglomerular cells and interact with calcium signaling to decrease renin release. FASEB J 25:824

    Google Scholar 

  272. Osmond DA, Inscho EW (2010) P2X1 receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo. Am J Physiol Ren Physiol 298:F1360–F1368

    CAS  Google Scholar 

  273. Osswald H (1984) The role of adenosine in the regulation of glomerular filtration rate and renin secretion. Trends Pharmacol Sci 5:94–97

    CAS  Google Scholar 

  274. Osswald H, Schmitz HJ, Kemper R (1978) Renal action of adenosine: effect on renin secretion in the rat. Naunyn Schmiedebergs Arch Pharmacol 303:95–99

    PubMed  CAS  Google Scholar 

  275. Ostrom RS, Gregorian C, Insel PA (2000) Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways. J Biol Chem 275:11735–11739

    PubMed  CAS  Google Scholar 

  276. Ostrom RS, Gregorian C, Drenan RM, Gabot K, Rana BK, Insel PA (2001) Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP. Am J Physiol Cell Physiol 281:C524–C531

    PubMed  CAS  Google Scholar 

  277. Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Ryan RP, Cowley AW Jr, Staruschenko A (2013) Real-time electrochemical detection of ATP and H2O2 release in freshly isolated kidneys. Am J Physiol Ren Physiol 305:F134–F141

    CAS  Google Scholar 

  278. Panico C, Luo Z, Welch WJ (2011) Inhibition of adenosine type 2 receptors increases fluid uptake in the proximal tubule. FASEB J 25:665

    Google Scholar 

  279. Patel A, Honoré E (2010) Polycystins and renovascular mechanosensory transduction. Nat Rev Nephrol 6:530–538

    PubMed  CAS  Google Scholar 

  280. Paulais M, Baudouin-Legros M, Teulon J (1995) Extracellular ATP and UTP trigger calcium entry in mouse cortical thick ascending limbs. Am J Physiol 268:F496–F502

    PubMed  CAS  Google Scholar 

  281. Paulmichl M, Pfeilschifter J, Wöll E, Lang F (1991) Cellular mechanisms of ATP-induced hyperpolarization in renal epitheloid MDCK-cells. J Cell Physiol 147:68–75

    PubMed  CAS  Google Scholar 

  282. Pavenstädt H, Gloy J, Leipziger J, Klär B, Pfeilschifter J, Schollmeyer P, Greger R (1993) Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture. Br J Pharmacol 109:953–959

    PubMed  Google Scholar 

  283. Pavenstädt H, Ruh J, Greger R, Schollmeyer P (1994) Adenosine-induced hyperpolarization of the membrane voltage in rat mesangial cells in primary culture. Br J Pharmacol 113:7–12

    PubMed Central  PubMed  Google Scholar 

  284. Pellerin I, Leclerc M, Claveau D, Mailloux J, Brunette MG (2001) Roles of ATP and cytoskeleton in the regulation of Na+/H+ exchanger along the nephron luminal membrane. J Cell Physiol 187:109–116

    PubMed  CAS  Google Scholar 

  285. Peti-Peterdi J (2006) Calcium wave of tubuloglomerular feedback. Am J Physiol Ren Physiol 291:F473–F480

    CAS  Google Scholar 

  286. Pfeilschifter J (1990) Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. Biochem J 272:469–472

    PubMed Central  PubMed  CAS  Google Scholar 

  287. Piwkowska A, Rogacka D, Jankowski M, Angielski S (2011) Extracellular ATP through P2 receptors activates AMP-activated protein kinase and suppresses superoxide generation in cultured mouse podocytes. Exp Cell Res 317:1904–1913

    PubMed  CAS  Google Scholar 

  288. Pochynyuk O, Bugaj V, Stockand JD (2008) Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens 17:533–540

    PubMed Central  PubMed  CAS  Google Scholar 

  289. Pochynyuk O, Bugaj V, Vandewalle A, Stockand JD (2008) Purinergic control of apical plasma membrane PI(4,5)P2 levels sets ENaC activity in principal cells. Am J Physiol Ren Physiol 294:F38–F46

    CAS  Google Scholar 

  290. Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD (2008) Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem 283:36599–36607

    PubMed Central  PubMed  CAS  Google Scholar 

  291. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V (2010) Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J 24:2056–2065

    PubMed Central  PubMed  CAS  Google Scholar 

  292. Poelstra K, Heynen ER, Baller JF, Hardonk MJ, Bakker WW (1992) Modulation of anti-Thy1 nephritis in the rat by adenine nucleotides. Evidence for an anti-inflammatory role for nucleotidases. Lab Invest 66:555–563

    PubMed  CAS  Google Scholar 

  293. Ponnusamy M, Ma L, Gong R, Pang M, Chin YE, Zhuang S (2011) P2X7 receptors mediate deleterious renal epithelial–fibroblast cross talk. Am J Physiol Ren Physiol 300:F62–F70

    CAS  Google Scholar 

  294. Ponnusamy M, Liu N, Gong R, Yan H, Zhuang S (2011) ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells. Am J Physiol Ren Physiol 301:F650–F659

    CAS  Google Scholar 

  295. Post SR, Rump LC, Zambon A, Hughes RJ, Buda MD, Jacobson JP, Kao CC, Insel PA (1998) ATP activates cAMP production via multiple purinergic receptors in MDCK-D1 epithelial cells. Blockade of an autocrine/paracrine pathway to define receptor preference of an agonist. J Biol Chem 273:23093–23097

    PubMed  CAS  Google Scholar 

  296. Praetorius HA, Leipziger J (2009) Released nucleotides amplify the cilium-dependent, flow-induced [Ca2+]i response in MDCK cells. Acta Physiol (Oxf) 197:241–251

    CAS  Google Scholar 

  297. Praetorius HA, Leipziger J (2010) Intrarenal purinergic signaling in the control of renal tubular transport. Annu Rev Physiol 72:377–393

    PubMed  CAS  Google Scholar 

  298. Praetorius HA, Leipziger J (2013) Primary cilium-dependent sensing of urinary flow and paracrine purinergic signaling. Semin Cell Dev Biol 24:3–10

    PubMed  CAS  Google Scholar 

  299. Praetorius HA, Frøkiaer J, Leipziger J (2005) Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells. Am J Physiol Ren Physiol 288:F133–F141

    CAS  Google Scholar 

  300. Qu LP, Xue H, Yuan P, Zhou L, Yao T, Huang Y, Lu LM (2009) Adenosine 5′-triphosphate stimulates the increase of TGF-β1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2. Acta Pharmacol Sin 30:1601–1606

    PubMed  CAS  Google Scholar 

  301. Quezada C, Alarcón S, Jaramillo C, Muñoz D, Oyarzún C, San Martín R (2013) Targeting adenosine signaling to treatment of diabetic nephropathy. Curr Drug Targets 14:490–496

    PubMed  CAS  Google Scholar 

  302. Rajagopal M, Pao AC (2010) Adenosine activates AS2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells. Hypertension 55:1123–1128

    PubMed Central  PubMed  CAS  Google Scholar 

  303. Rajagopal M, Kathpalia PP, Thomas SV, Pao AC (2011) Activation of P2Y1 and P2Y2 receptors induces chloride secretion via calcium-activated chloride channels in kidney inner medullary collecting duct cells. Am J Physiol Ren Physiol 301:F544–F553

    CAS  Google Scholar 

  304. Rajagopal M, Kathpalia PP, Widdicombe JH, Pao AC (2012) Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Ren Physiol 303:F483–F491

    CAS  Google Scholar 

  305. Rajakumar SV, Lu B, Crikis S, Robson SC, d’Apice AJ, Cowan PJ, Dwyer KM (2010) Deficiency or inhibition of CD73 protects in mild kidney ischemia–reperfusion injury. Transplantation 90:1260–1264

    PubMed  CAS  Google Scholar 

  306. Ren J, Mi Z, Jackson EK (2008) Assessment of nerve stimulation-induced release of purines from mouse kidneys by tandem mass spectrometry. J Pharmacol Exp Ther 325:920–926

    PubMed  CAS  Google Scholar 

  307. Ren Y, Carretero OA, Garvin JL (2002) Role of mesangial cells and gap junctions in tubuloglomerular feedback. Kidney Int 62:525–531

    PubMed  Google Scholar 

  308. Rieg T, Vallon V (2009) ATP and adenosine in the local regulation of water transport and homeostasis by the kidney. Am J Physiol Regul Integr Comp Physiol 296:R419–R427

    PubMed Central  PubMed  CAS  Google Scholar 

  309. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V (2007) Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na + and water reabsorption. FASEB J 21:3717–3726

    PubMed  CAS  Google Scholar 

  310. Rieg T, Gerasimova M, Boyer JL, Insel PA, Vallon V (2011) P2Y2 receptor activation decreases blood pressure and increases renal Na+ excretion. Am J Physiol Regul Integr Comp Physiol 301:R510–R518

    PubMed Central  PubMed  CAS  Google Scholar 

  311. Rivera I, Zhang S, Fuller BS, Edwards B, Seki T, Wang MH, Marrero MB, Inscho EW (2007) P2 receptor regulation of [Ca2+]i in cultured mouse mesangial cells. Am J Physiol Ren Physiol 292:F1380–F1389

    CAS  Google Scholar 

  312. Robson L, Hunter M (1997) Two K+-selective conductances in single proximal tubule cells isolated from frog kidney are regulated by ATP. J Physiol 500:605–616

    PubMed Central  PubMed  CAS  Google Scholar 

  313. Rost S, Daniel C, Schulze-Lohoff E, Bäumert HG, Lambrecht G, Hugo C (2002) P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis. Kidney Int 62:1659–1671

    PubMed  CAS  Google Scholar 

  314. Rouse D, Leite M, Suki WN (1994) ATP inhibits the hydrosmotic effect of AVP in rabbit CCT: evidence for a nucleotide P2u receptor. Am J Physiol 267:F289–F295

    PubMed  CAS  Google Scholar 

  315. Rubera I, Tauc M, Bidet M, Verheecke-Mauze C, De Renzis G, Poujeol C, Cuiller B, Poujeol P (2000) Extracellular ATP increases [Ca2+]i in distal tubule cells. II. Activation of a Ca2+-dependent Cl conductance. Am J Physiol Ren Physiol 279:F102–F111

    CAS  Google Scholar 

  316. Rubera I, Barrière H, Tauc M, Bidet M, Verheecke-Mauze C, Poujeol C, Cuiller B, Poujeol P (2001) Extracellular adenosine modulates a volume-sensitive-like chloride conductance in immortalized rabbit DC1 cells. Am J Physiol Ren Physiol 280:F126–F145

    CAS  Google Scholar 

  317. Scemes E, Spray DC, Meda P (2009) Connexins, pannexins, innexins: novel roles of “hemi-channels”. Pflugers Arch 457:1207–1226

    PubMed Central  PubMed  CAS  Google Scholar 

  318. Schlatter E, Ankorina I, Haxelmans S, Kleta R (1995) Effects of diadenosine polyphosphates, ATP and angiotensin II on cytosolic Ca2+ activity and contraction of rat mesangial cells. Pflugers Arch 430:721–728

    PubMed  CAS  Google Scholar 

  319. Schnermann J (2011) Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice. Am J Physiol Ren Physiol 300:F339–F344

    CAS  Google Scholar 

  320. Schnermann J, Levine DZ (2003) Paracrine factors in tubuloglomerular feedback: adenosine, ATP, and nitric oxide. Annu Rev Physiol 65:501–529

    PubMed  CAS  Google Scholar 

  321. Schnermann J, Briggs JP (2008) Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice. Kidney Int 74:418–426

    PubMed Central  PubMed  CAS  Google Scholar 

  322. Scholz-Pedretti K, Pfeilschifter J, Kaszkin M (2001) Potentiation of cytokine induction of group IIA phospholipase A2 in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor. Br J Pharmacol 132:37–46

    PubMed Central  PubMed  CAS  Google Scholar 

  323. Schulze-Lohoff E, Zanner S, Ogilvie A, Sterzel RB (1992) Extracellular ATP stimulates proliferation of cultured mesangial cells via P2-purinergic receptors. Am J Physiol 263:F374–F383

    PubMed  CAS  Google Scholar 

  324. Schulze-Lohoff E, Schagerl S, Ogilvie A, Sterzel RB (1995) Extracellular ATP augments mesangial cell growth induced by multiple growth factors. Nephrol Dial Transplant 10:2027–2034

    PubMed  CAS  Google Scholar 

  325. Schulze-Lohoff E, Zanner S, Ogilvie A, Sterzel RB (1995) Vasoactive diadenosine polyphosphates promote growth of cultured renal mesangial cells. Hypertension 26:899–904

    PubMed  CAS  Google Scholar 

  326. Schulze-Lohoff E, Hugo C, Rost S, Arnold S, Gruber A, Brüne B, Sterzel RB (1998) Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7 receptors. Am J Physiol 275:F962–F971

    PubMed  CAS  Google Scholar 

  327. Schweda F, Segerer F, Castrop H, Schnermann J, Kurtz A (2005) Blood pressure-dependent inhibition of renin secretion requires A1 adenosine receptors. Hypertension 46:780–786

    PubMed  CAS  Google Scholar 

  328. Schwiebert EM (2001) ATP release mechanisms, ATP receptors and purinergic signalling along the nephron. Clin Exp Pharmacol Physiol 28:340–350

    PubMed  CAS  Google Scholar 

  329. Schwiebert EM, Wallace DP, Braunstein GM, King SR, Peti-Peterdi J, Hanaoka K, Guggino WB, Guay-Woodford LM, Bell PD, Sullivan LP, Grantham JJ, Taylor AL (2002) Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Ren Physiol 282:F763–F775

    CAS  Google Scholar 

  330. Shaik ZP, Fifer EK, Nowak G (2007) Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells. Am J Physiol Ren Physiol 292:F292–F303

    CAS  Google Scholar 

  331. Shaver SR, Rideout JL, Pendergast W, Douglass JG, Brown EG, Boyer JL, Patel RI, Redick CC, Jones AC, Picher M, Yerxa BR (2005) Structure–activity relationships of dinucleotides: potent and selective agonists of P2Y receptors. Purinergic Signal 1:183–191

    PubMed Central  PubMed  CAS  Google Scholar 

  332. Shirley DG, Bailey MA, Unwin RJ (2005) In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption. Am J Physiol Ren Physiol 288:F1243–F1248

    CAS  Google Scholar 

  333. Shirley DG, Vekaria RM, Sévigny J (2009) Ectonucleotidases in the kidney. Purinergic Signal 5:501–511

    PubMed Central  PubMed  CAS  Google Scholar 

  334. Shrivastava AN, Triller A, Sieghart W, Sarto-Jackson I (2011) Regulation of GABAA receptor dynamics by interaction with purinergic P2X2 receptors. J Biol Chem 286:14455–14468

    PubMed Central  PubMed  CAS  Google Scholar 

  335. Siegel NJ, Glazier WB, Chaudry IH, Gaudio KM, Lytton B, Baue AE, Kashgarian M (1980) Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats. Kidney Int 17:338–349

    PubMed  CAS  Google Scholar 

  336. Siegel NJ, Avison MJ, Reilly HF, Alger JR, Shulman RG (1983) Enhanced recovery of renal ATP with postischemic infusion of ATP-MgCl2 determined by 31P-NMR. Am J Physiol 245:F530–F534

    PubMed  CAS  Google Scholar 

  337. Silva GB, Garvin JL (2008) TRPV4 mediates hypotonicity-induced ATP release by the thick ascending limb. Am J Physiol Ren Physiol 295:F1090–F1095

    CAS  Google Scholar 

  338. Silva GB, Garvin JL (2009) Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs. Am J Physiol Ren Physiol 297:F646–F652

    CAS  Google Scholar 

  339. Silva GB, Garvin JL (2009) Extracellular ATP inhibits transport in medullary thick ascending limbs: role of P2X receptors. Am J Physiol Ren Physiol 297:F1168–F1173

    CAS  Google Scholar 

  340. Silva GB, Beierwaltes WH, Garvin JL (2006) Extracellular ATP stimulates NO production in rat thick ascending limb. Hypertension 47:563–567

    PubMed  CAS  Google Scholar 

  341. Simmons NL (1981) Identification of a purine (P2) receptor linked to ion transport in a cultured renal (MDCK) epithelium. Br J Pharmacol 73:379–384

    PubMed Central  PubMed  CAS  Google Scholar 

  342. Sipos A, Vargas SL, Toma I, Hanner F, Willecke K, Peti-Peterdi J (2009) Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis. J Am Soc Nephrol 20:1724–1732

    PubMed Central  PubMed  CAS  Google Scholar 

  343. Skøtt O, Baumbach L (1985) Effects of adenosine on renin release from isolated rat glomeruli and kidney slices. Pflugers Arch 404:232–237

    PubMed  Google Scholar 

  344. Smith JA, Whitaker EM, Bowmer CJ, Yates MS (2000) Differential expression of renal adenosine A1 receptors induced by acute renal failure. Biochem Pharmacol 59:727–732

    PubMed  CAS  Google Scholar 

  345. Smith JA, Sivaprasadarao A, Munsey TS, Bowmer CJ, Yates MS (2001) Immunolocalisation of adenosine A1 receptors in the rat kidney. Biochem Pharmacol 61:237–244

    PubMed  CAS  Google Scholar 

  346. Solini A, Iacobini C, Ricci C, Chiozzi P, Amadio L, Pricci F, Di MU, Di Virgilio F, Pugliese G (2005) Purinergic modulation of mesangial extracellular matrix production: role in diabetic and other glomerular diseases. Kidney Int 67:875–885

    PubMed  CAS  Google Scholar 

  347. Solini A, Santini E, Chimenti D, Chiozzi P, Pratesi F, Cuccato S, Falzoni S, Lupi R, Ferrannini E, Pugliese G, Di Virgilio F (2007) Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4. Am J Physiol Ren Physiol 292:F1537–F1547

    CAS  Google Scholar 

  348. Souza-Menezes J, Morales M (2009) CFTR structure and function: is there a role in the kidney? Biophys Rev 1:3–12

    CAS  Google Scholar 

  349. Spielman WS, Arend LJ (1991) Adenosine receptors and signaling in the kidney. Hypertension 17:117–130

    PubMed  CAS  Google Scholar 

  350. Stefanovic V, Vlahovic P (1995) A2 adenosine receptors in human glomerular mesangial cells. Experientia 51:360–362

    PubMed  CAS  Google Scholar 

  351. Steinhausen M, Blum M, Fleming JT, Holz FG, Parekh N, Wiegman DL (1989) Visualization of renal autoregulation in the split hydronephrotic kidney of rats. Kidney Int 35:1151–1160

    PubMed  CAS  Google Scholar 

  352. Stewart GS, Glanville M, Aziz O, Simmons NL, Gray MA (2001) Regulation of an outwardly rectifying chloride conductance in renal epithelial cells by external and internal calcium. J Membr Biol 180:49–64

    PubMed  CAS  Google Scholar 

  353. Stiepanow-Trzeciak A, Jankowski M, Angielski S, Szczepanska-Konkel M (2007) P1, P4-diadenosine tetraphosphate (Ap4A) inhibits proximal tubular reabsorption of sodium in rats. Nephron Physiol 106:13–18

    Google Scholar 

  354. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O (2010) Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol 21:1903–1911

    PubMed Central  PubMed  CAS  Google Scholar 

  355. Sumpio BE, Chaudry IH, Baue AE (1985) Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-diamminedichloroplatinum-treated isolated perfused kidneys. J Surg Res 38:429–437

    PubMed  CAS  Google Scholar 

  356. Sun D, Samuelson LC, Yang T, Huang Y, Paliege A, Saunders T, Briggs J, Schnermann J (2001) Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci U S A 98:9983–9988

    PubMed Central  PubMed  CAS  Google Scholar 

  357. Sun R, Carlson NG, Hemmert AC, Kishore BK (2005) P2Y 2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Am J Physiol Ren Physiol 289:F585–F592

    CAS  Google Scholar 

  358. Suzuki F, Shimada J, Mizumoto H, Karasawa A, Kubo K, Nonaka H, Ishii A, Kawakita T (1992) Adenosine A1 antagonists. 2. Structure–activity relationships on diuretic activities and protective effects against acute renal failure. J Med Chem 35:3066–3075

    PubMed  CAS  Google Scholar 

  359. Szczepanska-Konkel M, Jankowski M, Stiepanow-Trzeciak A, Angielski S (2005) Effects of diadenosine polyphosphates on glomerular volume. Br J Pharmacol 144:1109–1117

    PubMed Central  PubMed  CAS  Google Scholar 

  360. Takeda M, Yoshitomi K, Imai M (1993) Regulation of Na+-3HCO3 - cotransport in rabbit proximal convoluted tubule via adenosine A1 receptor. Am J Physiol 265:F511–F519

    PubMed  CAS  Google Scholar 

  361. Takeda M, Kawamura T, Kobayashi M, Endou H (1996) ATP-induced calcium mobilization in glomerular mesangial cells is mediated by P2U purinoceptor. Biochem Mol Biol Int 39:1193–1200

    PubMed  CAS  Google Scholar 

  362. Takenaka T, Hayashi K, Ikenaga H (2004) Blood pressure regulation and renal microcirculation. Contrib Nephrol 143:46–64

    PubMed  Google Scholar 

  363. Takenaka T, Okada H, Kanno Y, Inoue T, Ryuzaki M, Nakamoto H, Kawachi H, Shimizu F, Suzuki H (2006) Exogenous 5′-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats. Am J Physiol Ren Physiol 290:F844–F853

    CAS  Google Scholar 

  364. Takenaka T, Inoue T, Kanno Y, Okada H, Hill CE, Suzuki H (2008) Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation. Am J Physiol Regul Integr Comp Physiol 294:R1–R11

    PubMed  CAS  Google Scholar 

  365. Tamura Y, Tanabe K, Kitagawa W, Uchida S, Schreiner GF, Johnson RJ, Nakagawa T (2012) Nicorandil, a Katp channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Ren Physiol 303:F339–F349

    CAS  Google Scholar 

  366. Taneyama C, Goto H, Benson KT, Unruh GK, Arakawa K (1991) Vagal involvement in the action of exogenous adenosine triphosphate on reflex renal sympathetic nerve activity. Anesth Analg 72:351–358

    PubMed  CAS  Google Scholar 

  367. Tang Y, Zhou L (2003) Characterization of adenosine A1 receptors in human proximal tubule epithelial (HK-2) cells. Receptors Channels 9:67–75

    PubMed  CAS  Google Scholar 

  368. Taylor SRJ, Turner CM, Elliott JI, Hewitt R, Pickering M, Cook HT, Burnstock G, Pusey CD, Unwin R, Tam FWK (2009) P2X7-deficiency ameliorates accelerated nephrotoxic nephritis in mice. J Am Soc Nephrol 20:1275–1281

    PubMed Central  PubMed  CAS  Google Scholar 

  369. Teitelbaum I (1992) Hormone signaling systems in inner medullary collecting ducts. Am J Physiol 263:F985–F990

    PubMed  CAS  Google Scholar 

  370. Thomas J, Deetjen P, Ko WH, Jacobi C, Leipziger J (2001) P2Y2 receptor-mediated inhibition of amiloride-sensitive short circuit current in M-1 mouse cortical collecting duct cells. J Membr Biol 183:115–124

    PubMed  CAS  Google Scholar 

  371. Toma I, Bansal E, Meer EJ, Kang JJ, Vargas SL, Peti-Peterdi J (2008) Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells. Am J Physiol Regul Integr Comp Physiol 294:R1769–R1776

    PubMed Central  PubMed  CAS  Google Scholar 

  372. Toney GM, Vallon V, Stockand JD (2012) Intrinsic control of sodium excretion in the distal nephron by inhibitory purinergic regulation of the epithelial Na+ channel. Curr Opin Nephrol Hypertens 21:52–60

    PubMed Central  PubMed  CAS  Google Scholar 

  373. Torres B, Zambon AC, Insel PA (2002) P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D1 cells. A mechanism for nucleotide-mediated autocrine–paracrine regulation. J Biol Chem 277:7761–7765

    PubMed  CAS  Google Scholar 

  374. Tran E, Sun H, Fang Y (2012) Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. Assay Drug Dev Technol 10:37–45

    PubMed Central  PubMed  CAS  Google Scholar 

  375. Turner C, Vonend O, Chan CM, Burnstock G, Unwin RJ (2003) The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study. Cells Tissues Org 175:105–117

    CAS  Google Scholar 

  376. Turner C, Ramesh B, Srai SKS, Burnstock G, Unwin R (2004) Altered P2 receptor expression in the Han:SPRD cy/+ rat, a model of autosomal dominant polycystic kidney disease. Cells Tissues Org 178:168–179

    CAS  Google Scholar 

  377. Turner CM, King BF, Srai KS, Unwin RJ (2007) Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro. Am J Physiol Ren Physiol 292:F15–F25

    CAS  Google Scholar 

  378. Turner CM, Tam F, Lai P-C, Tarzi RM, Burnstock G, Pusey CD, Cook HT, Unwin RJ (2007) Increased expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human glomerulonephritis. Nephrol Dial Transplant 22:386–395

    PubMed  CAS  Google Scholar 

  379. Turner CM, Elliott JI, Tam FW (2009) P2 receptors in renal pathophysiology. Purinergic Signal 5:513–520

    PubMed Central  PubMed  CAS  Google Scholar 

  380. Udagawa T, Hanaoka K, Kawamura M, Hosoya T (2012) Characteristics of spontaneous calcium oscillations in renal tubular epithelial cells. Clin Exp Nephrol 16:389–398

    PubMed  CAS  Google Scholar 

  381. Unwin RJ, Bailey MA, Burnstock G (2003) Purinergic signaling along the renal tubule: the current state of play. News Physiol Sci 18:237–241

    PubMed  CAS  Google Scholar 

  382. Vallon V (2008) P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Ren Physiol 294:F10–F27

    CAS  Google Scholar 

  383. Vallon V, Rieg T (2011) Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. Am J Physiol Ren Physiol 301:F463–F475

    CAS  Google Scholar 

  384. Vallon V, Mühlbauer B, Osswald H (2006) Adenosine and kidney function. Physiol Rev 86:901–940

    PubMed  CAS  Google Scholar 

  385. van der Weyden L, Adams DJ, Morris BJ (2000) Capacity for purinergic control of renin promoter via P2Y11 receptor and cAMP pathways. Hypertension 36:1093–1098

    Google Scholar 

  386. Vargas F, Osuna A, Fernández-Rivas A (1996) Renal vascular reactivity to ATP in hyper- and hypothyroid rats. Experientia 52:225–229

    PubMed  CAS  Google Scholar 

  387. Vekaria RM (2004) Vesicular storage and release of ATP in a rat proximal tubule cell line. J Physiol 560:C17

    Google Scholar 

  388. Vekaria RM, Unwin RJ, Shirley DG (2006) Intraluminal ATP concentrations in rat renal tubules. J Am Soc Nephrol 17:1841–1847

    PubMed  CAS  Google Scholar 

  389. Vekaria RM, Shirley DG, Sevigny J, Unwin RJ (2006) Immunolocalization of ectonucleotidases along the rat nephron. Am J Physiol Ren Physiol 290:F550–F560

    CAS  Google Scholar 

  390. Vitzthum H, Weiss B, Bachleitner W, Krämer BK, Kurtz A (2004) Gene expression of adenosine receptors along the nephron. Kidney Int 65:1180–1190

    PubMed  CAS  Google Scholar 

  391. Vonend O, Oberhauser V, von Kügelgen I, Apel TW, Amann K, Ritz E, Rump LC (2002) ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells. Kidney Int 61:1617–1626

    PubMed  CAS  Google Scholar 

  392. Vonend O, Grote T, Oberhauser V, von Kügelgen I, Rump LC (2003) P2Y-receptors stimulating the proliferation of human mesangial cells through the MAPK42/44 pathway. Br J Pharmacol 139:1119–1126

    PubMed Central  PubMed  CAS  Google Scholar 

  393. Vonend O, Turner C, Chan CM, Loesch A, Dell’Anna GC, Srai SK, Burnstock G, Unwin R (2004) Glomerular expression of the ATP-sensitive P2X7 receptor in diabetic and hypertensive rat models. Kidney Int 66:157–166

    PubMed  CAS  Google Scholar 

  394. Walker M III, Harrison-Bernard LM, Cook AK, Navar LG (2000) Dynamic interaction between myogenic and TGF mechanisms in afferent arteriolar blood flow autoregulation. Am J Physiol Ren Physiol 279:F858–F865

    CAS  Google Scholar 

  395. Wang J, Ouyang C, Chen X, Fu B, Lu Y, Hong Q (2008) STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron Exp Nephrol 108:e11–e18

    PubMed  CAS  Google Scholar 

  396. Wang Y, Knowlton AA, Christensen TG, Shih T, Borkan SC (1999) Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. Kidney Int 55:2224–2235

    PubMed  CAS  Google Scholar 

  397. Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI (2012) Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol 42:2441–2451

    PubMed  CAS  Google Scholar 

  398. Weaver DR, Reppert SM (1992) Adenosine receptor gene expression in rat kidney. Am J Physiol 263:F991–F995

    PubMed  CAS  Google Scholar 

  399. Wei Q, Wang J, Wang MH, Yu F, Dong Z (2004) Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion. Am J Physiol Ren Physiol 287:F492–F500

    CAS  Google Scholar 

  400. Weinbaum S, Duan Y, Satlin LM, Wang T, Weinstein AM (2010) Mechanotransduction in the renal tubule. Am J Physiol Ren Physiol 299:F1220–F1236

    CAS  Google Scholar 

  401. Welch BD, Carlson NG, Shi H, Myatt L, Kishore BK (2003) P2Y2 receptor-stimulated release of prostaglandin E2 by rat inner medullary collecting duct preparations. Am J Physiol Ren Physiol 285:F711–F721

    CAS  Google Scholar 

  402. Welch WJ (2002) Adenosine A1 receptor antagonists in the kidney: effects in fluid-retaining disorders. Curr Opin Pharmacol 2:165–170

    PubMed  CAS  Google Scholar 

  403. Welch WJ (2002) Adenosine type 1 receptor antagonists in fluid retaining disorders. Expert Opin Inv Drugs 11:1553–1562

    CAS  Google Scholar 

  404. Welch WJ, Solis G, Wilcox CS (2011) Adenosine receptors in the proximal tubule modulate deoxycorticosterone acetate (DOCA)-salt hypertension in mice. Hypertension 58:e60

    Google Scholar 

  405. Wellhauser L, Luna-Chavez C, D’Antonio C, Tainer J, Bear CE (2011) ATP induces conformational changes in the carboxyl-terminal region of ClC-5. J Biol Chem 286:6733–6741

    PubMed Central  PubMed  CAS  Google Scholar 

  406. Wengert M, Berto C Jr, Kaufman J, Leão-Ferreira LR, Paes-de-Carvalho R, Lopes AG, Caruso-Neves C (2005) Stimulation of the proximal tubule Na+-ATPase activity by adenosine A2A receptor. Int J Biochem Cell Biol 37:155–165

    PubMed  CAS  Google Scholar 

  407. Wierema TK, Postma CT, Houben AJ, Kroon AA, Thien T, Smits P, de Leeuw PW (1998) Adenosine-induced renal vasodilatation is prolonged in renal artery stenosis. J Hypertens 16:2109–2112

    PubMed  CAS  Google Scholar 

  408. Wierema TK, Houben AJ, Kroon AA, Postma CT, Koster D, van Engelshoven JM, Smits P, de Leeuw PW (2005) Mechanisms of adenosine-induced renal vasodilatation in hypertensive patients. J Hypertens 23:1731–1736

    PubMed  CAS  Google Scholar 

  409. Wildman SS, King BF (2008) P2X receptors: epithelial ion channels and regulators of salt and water transport. Nephron Physiol 108:60–67

    Google Scholar 

  410. Wildman SS, Unwin RJ, King BF (2003) Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions. Br J Pharmacol 140:1177–1186

    PubMed Central  PubMed  CAS  Google Scholar 

  411. Wildman SS, Marks J, Churchill LJ, Peppiatt CM, Chraibi A, Shirley DG, Horisberger JD, King BF, Unwin RJ (2005) Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors. J Am Soc Nephrol 16:2586–2597

    PubMed  CAS  Google Scholar 

  412. Wildman SS, Turner CM, Marks J, Shirley DG, King BF, Unwin RJ (2007) Differential regulation of renal ENaC by apical P2X and P2Y receptors. FASEB J 21:937.3

    Google Scholar 

  413. Wildman SS, Marks J, Turner CM, Yew-Booth L, Peppiatt-Wildman CM, King BF, Shirley DG, Wang W, Unwin RJ (2008) Sodium-dependent regulation of renal amiloride-sensitive currents by apical P2 receptors. J Am Soc Nephrol 19:731–742

    PubMed Central  PubMed  CAS  Google Scholar 

  414. Wildman SS, Kang ES, King BF (2009) ENaC, renal sodium excretion and extracellular ATP. Purinergic Signal 5:481–489

    PubMed Central  PubMed  CAS  Google Scholar 

  415. Wildman SS, Boone M, Peppiatt-Wildman CM, Contreras-Sanz A, King BF, Shirley DG, Deen PM, Unwin RJ (2009) Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors. J Am Soc Nephrol 20:1480–1490

    PubMed Central  PubMed  CAS  Google Scholar 

  416. Wilson PD, Hovater JS, Casey CC, Fortenberry JA, Schwiebert EM (1999) ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys. J Am Soc Nephrol 10:218–229

    PubMed  CAS  Google Scholar 

  417. Xia SL, Wang L, Cash MN, Teng X, Schwalbe RA, Wingo CS (2004) Extracellular ATP-induced calcium signaling in mIMCD-3 cells requires both P2X and P2Y purinoceptors. Am J Physiol Ren Physiol 287:F204–F214

    CAS  Google Scholar 

  418. Xiao H, Shen HY, Liu W, Xiong RP, Li P, Meng G, Yang N, Chen X, Si LY, Zhou YG (2013) Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. PLoS One 8:e60173

    PubMed Central  PubMed  CAS  Google Scholar 

  419. Xie Y, Schafer JA (2008) Endogenous ATP release inhibits electrogenic Na+ absorption and stimulates Cl secretion in MDCK cells. Purinergic Signal 4:125–137

    PubMed Central  PubMed  CAS  Google Scholar 

  420. Xin C, Ren S, Pfeilschifter J, Huwiler A (2004) Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. Br J Pharmacol 143:581–589

    PubMed Central  PubMed  CAS  Google Scholar 

  421. Xu C, Shmukler BE, Nishimura K, Kaczmarek E, Rossetti S, Harris PC, Wandinger-Ness A, Bacallao RL, Alper SL (2009) Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai 2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Ren Physiol 296:F1464–F1476

    CAS  Google Scholar 

  422. Yamada H, Seki G, Taniguchi S, Uwatoko S, Suzuki K, Kurokawa K (1996) Mechanism of [Ca2+]i increase by extracellular ATP in isolated rabbit renal proximal tubules. Am J Physiol 270:C1096–C1104

    PubMed  CAS  Google Scholar 

  423. Yamaguchi S, Umemura S, Tamura K, Iwamoto T, Nyui N, Ishigami T, Ishii M (1995) Adenosine A1 receptor mRNA in microdissected rat nephron segments. Hypertension 26:1181–1185

    PubMed  CAS  Google Scholar 

  424. Yao J, Suwa M, Li B, Kawamura K, Morioka T, Oite T (2003) ATP-dependent mechanism for coordination of intercellular Ca2+ signaling and renin secretion in rat juxtaglomerular cells. Circ Res 93:338–345

    PubMed  CAS  Google Scholar 

  425. Yap SC, Lee HT (2012) Adenosine and protection from acute kidney injury. Curr Opin Nephrol Hypertens 21:24–32

    PubMed Central  PubMed  CAS  Google Scholar 

  426. Zambon AC, Hughes RJ, Meszaros JG, Wu JJ, Torres B, Brunton LL, Insel PA (2000) P2Y2 receptor of MDCK cells: cloning, expression, and cell-specific signaling. Am J Physiol Ren Physiol 279:F1045–F1052

    CAS  Google Scholar 

  427. Zambon AC, Brunton LL, Barrett KE, Hughes RJ, Torres B, Insel PA (2001) Cloning, expression, signaling mechanisms, and membrane targeting of P2Y11 receptors in Madin Darby canine kidney cells. Mol Pharmacol 60:26–35

    PubMed  CAS  Google Scholar 

  428. Zamir M, Phipps S (1987) Morphometric analysis of the distributing vessels of the kidney. Can J Physiol Pharmacol 65:2433–2440

    PubMed  CAS  Google Scholar 

  429. Zarjou A, Agarwal A (2011) ATP as a death factor: purinergic signaling in renal epithelial–fibroblast cross talk. Am J Physiol Ren Physiol 300:F60–F61

    CAS  Google Scholar 

  430. Zegarra-Moran O, Romeo G, Galietta LJ (1995) Regulation of transepithelial ion transport by two different purinoceptors in the apical membrane of canine kidney (MDCK) cells. Br J Pharmacol 114:1052–1056

    PubMed Central  PubMed  CAS  Google Scholar 

  431. Zhang L, Yang N, Wang S, Huang B, Li F, Tan H, Liang Y, Chen M, Li Y, Yu X (2011) Adenosine 2A receptor is protective against renal injury in MRL/lpr mice. Lupus 20:667–677

    PubMed  CAS  Google Scholar 

  432. Zhang Y, Sanchez D, Gorelik J, Klenerman D, Lab M, Edwards C, Korchev Y (2007) Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. Am J Physiol Ren Physiol 292:F1734–F1740

    CAS  Google Scholar 

  433. Zhang Y, Sands JM, Kohan DE, Nelson RD, Martin CF, Carlson NG, Kamerath CD, Ge Y, Klein JD, Kishore BK (2008) Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Ren Physiol 295:F1715–F1724

    CAS  Google Scholar 

  434. Zhang Y, Listhrop R, Ecelbarger CM, Kishore BK (2011) Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NaCl diet with/without aldosterone infusion. Am J Physiol Ren Physiol 300:F657–F668

    CAS  Google Scholar 

  435. Zhang Y, Pop IL, Carlson NG, Kishore BK (2012) Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling. Am J Physiol Ren Physiol 302:F70–F77

    CAS  Google Scholar 

  436. Zhao J, Wang H, Dai C, Wang H, Zhang H, Huang Y, Wang S, Gaskin F, Yang N, Fu SM (2013) P2X7 blockade attenuates lupus nephritis by inhibiting NLRP3/ASC/caspase-1 activation. Arthritis Rheum

  437. Zhao Z, Kapoian T, Shepard M, Lianos EA (2002) Adenosine-induced apoptosis in glomerular mesangial cells. Kidney Int 61:1276–1285

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors are very grateful to Dr Gillian E. Knight for her invaluable assistance in the preparation of this review article. The University/British Heart Foundation Centre for Cardiovascular Science is funded by The British Heart Foundation, Kidney Research UK.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Geoffrey Burnstock.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Burnstock, G., Evans, L.C. & Bailey, M.A. Purinergic signalling in the kidney in health and disease. Purinergic Signalling 10, 71–101 (2014). https://doi.org/10.1007/s11302-013-9400-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11302-013-9400-5

Keywords

Navigation