Skip to main content

Advertisement

SpringerLink
Log in

Influence of metals on rhinosinusal polyposis in Sardinian population (Italy)

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Metals have strong toxic effects in humans and can act as immunoregulatory factors. The purpose of our study was to determine whether the concentrations of metals are associated with the clinical course of nasal polyposis (NP). We measured the concentrations of 10 metals and non-metal (Zn, Mn, Se, Fe, Cr, Ni, Pb, Al, Cd, and Cu) in 58 patients with NP, and 29 controls with a healthy nasal mucosa. We used electron microscopy to compare the ultrastructural features of the nasal mucosa between NP patients and healthy controls. Concentrations of metals in nasal polyps and healthy mucosa were determined by mass spectrometry. Transmission electron microscopic (TEM) and scanning electron microscopic (SEM) images of the nasal mucosa were obtained. The mean tissue concentrations of all 10 metals and non-metal were significantly lower in NP patients than in healthy controls (P < 0.05).TEM and SEM revealed changes in the mucosal ultrastructure in NP with progressive fibrosis, devascularisation, and inflammation. Tissue concentrations of metals were lower in NP patients than in healthy controls, and this was particularly evident in massive polyposis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Al-Rawi MM, Edelstein DR, Erlandson RA (1998) Changes in nasal epithelium in patients with severe chronic sinusitis: a clinicopathologic and electron microscopic study. Laryngoscope 108(12):1816–1823

    Article  CAS  Google Scholar 

  • Asara Y, Marchal JA, Bandiera P, et al. (2012) Cadmium influences the 5-fluorouracil cytotoxic effects on breast cancer cells. Eur J Histochem 56:e1

    Article  CAS  Google Scholar 

  • Asara Y, Marchal JA, Carrasco E, et al. (2013) Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. Int J Mol Sci 14:16600–16616

    Article  Google Scholar 

  • Bent J, Kuhn F (1994) Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg 111:580–588

    Article  Google Scholar 

  • Bernstein JM, Gorfien J, Noble B (1995) Role of allergy in nasal polyposis: a review. Otolaryngol Head Neck Surg 113(6):724–732

    Article  CAS  Google Scholar 

  • Bezerra TF, Pádua FG, Ogawa AI, et al. (2009) Biofilm in chronic sinusitis with nasal polyps: pilot study. Braz J Otorhinolaryngol 75(6):788–793

    Article  Google Scholar 

  • Bocca B, Madeddu R, Asara Y, et al. (2011) Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population. J Trace Elem Med Biol 25:19–26

    Article  CAS  Google Scholar 

  • Bocca B, Forte G, Oggiano R, et al. (2015) Level of neurotoxic metals in amyotrophic lateral sclerosis: a population-based case–control study. J Neurol Sci 359:11–17

    Article  CAS  Google Scholar 

  • Fokkens W, Lund VJ, Mullol J, et al. (2007) EP3OS 2007: European position paper on rhinosinusitis and nasal polyps. A summary for otorhinolaryngologists Rhinology 45:1–87

    Google Scholar 

  • Forte G, Bocca B, Peruzzu A, et al. (2013) Blood metals concentration in type 1 and type 2 diabetics. Biol Trace Elem Res 156:79–90

    Article  CAS  Google Scholar 

  • Gelardi M, Fiorella ML, Russo C, et al. (2010) Role of nasal cytology. Int J Immunopathol Pharmacol (1 Suppl):45–49

  • Greisner WA, Settipane GA (1995) Hereditary factor for nasal polyps. J Allergy Clin Immunol; 95: 1(part 2) 205

  • Hartwig A (2013) Cadmium and cancer. Met Ions Life Sci 11:491–507

    Article  CAS  Google Scholar 

  • Ingrao G, Santaroni G, Tomassi G (1995) Trace elements: biological action and nutritional features in the man. Ann Ist Super Sanita 31(2):275–281

    CAS  Google Scholar 

  • Khlifi R, Olmedo P, Gil F, et al. (2014) Heavy metals in normal mucosa and nasal polyp tissues from Tunisian patients. Environ Sci Pollut Res 22(1):463–471

    Article  Google Scholar 

  • Khlifi R, Olmedo P, Gil F, et al. (2015) Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease. Environ Sci Pollut Res 22:3586–3593

    Article  CAS  Google Scholar 

  • Langdon C, Mullol J (2016) Nasal polyps in patients with asthma: prevalence, impact, and management challenges. J Asthma Allergy Mar 14(9):45–53

    Google Scholar 

  • Larsen K, Tos M (2002) The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol 122(2):179–182

    Article  Google Scholar 

  • Lund VJ (1995) Diagnosis and treatment of nasal polyps. BMJ 311(7017):1411–1414

    Article  CAS  Google Scholar 

  • Madeddu R, Tolu P, Asara Y, et al. (2013) Blood biomonitoring of metals in subjects living near abandoned mining and active industrial areas. Environ Monit Assess 185:5837–5846

    Article  CAS  Google Scholar 

  • Okur E, Gul A, Kilinc M, et al. (2013) Trace elements in nasal polyps. Eur Arch Otorhinolaryngol 270(8):2245–2248

    Article  Google Scholar 

  • Ozcan C, Zeren H, Talas DU, et al. (2005) Antrochoanal polyp: a transmission electron and light microscopic study. Eur Arch Otorhinolaryngol 262:55–60

    Article  Google Scholar 

  • Peruzzu A, Solinas G, Asara Y, et al. (2015) Association of 347 trace elements with lipid profiles and glycaemic control in patients with type 1 diabetes mellitus in northern Sardinia, Italy: an observational study. Chemosphere 132:101–107

    Article  CAS  Google Scholar 

  • Rostkowska Nadolska B, Borawska M, Hukalowicz K (2005) Trace elements in nasal polyps. Biol Trace Elem Res 106:117–121

    Article  CAS  Google Scholar 

  • Settipane GA, Chafee FH (1977) Nasal polyps in asthma and rhinitis: a review of 6, 037 patients. J Allergy Clin Immunol 59:17–21

    Article  CAS  Google Scholar 

  • Settipane GA (1996) Epidemiology of nasal polyps. Allergy Asthma Proc 17:231–236

    Article  CAS  Google Scholar 

  • Sies H, Cadenas E (1985) Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond Ser B Biol Sci 17:311(1152):617–631

    Article  Google Scholar 

  • Stammberger H (1999) Surgical treatment of nasal polyps: past, present and future. Allergy 54:7–11

    Article  Google Scholar 

  • Sturgess JM, Thompson MW, Czegledy-Nagy E, et al. (1986) Genetic aspects of immotile cilia syndrome. Am J Med Genet 25(1):149–160

    Article  CAS  Google Scholar 

  • Takeuchi K, Majima Y (2005) Remodeling in chronic sinusitis and nasal polyps. Allergol Int 54:39–43

    Article  Google Scholar 

  • Templeton DM (2003) The importance of trace element speciation in biomedical science. Anal Bioanal Chem 375(8):1062–1066

    CAS  Google Scholar 

  • Waalkes MP (2003) Cadmium carcinogenesis. Mutat Res 533:107–120

    Article  CAS  Google Scholar 

  • Wright DT, Cohn LA, Li H, et al. (1994) Interactions of oxygen radicals with airway epithelium. Environ Health Perspect 102(Suppl. 10):85–90

    Article  CAS  Google Scholar 

  • Zalewski PD, Truong-Tran AQ, Grosser D, et al. (2005) Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review Pharmacology & Therapeutics 105:127–149

    Article  CAS  Google Scholar 

  • Zernotti ME, Angel Villegas N, Roques Revol M, et al. (2010) Evidence of bacterial biofilms in nasal polyposis. J Investig Allergol Clin Immunol 20(5):380–385

    CAS  Google Scholar 

Download references

Acknowledgments

This study was partly supported by “Fondazione Banco di Sardegna”, Grant No. U1044.2013/AI.967. MGB–PRAT. 2013.1452.

Author information

Authors and Affiliations

  1. Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy

    Yolande Asara, Paolo Castiglia, Pasquale Bandiera & Roberto Madeddu

  2. INBB-National Institute of Biostructures and Biosystems, Sassari, Italy

    Yolande Asara & Roberto Madeddu

  3. Division of Otorhinolaryngology, Department of Surgery, Microsurgery and Medical Sciences, University of Sassari, Sassari, Italy

    Andrea Melis, Laura Maria De Luca & Apostolos Karligkiotis

  4. Division of Otorhinolaryngology, “P. Dettori” Hospital, Tempio Pausania, Italy

    Corrado Bozzo

  5. IZS-Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy

    Giannina Chessa & Patrizia Piras

  6. Department of Medical and Pediatric Science, Research Centre “The Great Senescence”, University of Catania, Catania, Italy

    Michele Malaguarnera

  7. Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain

    Juan Antonio Marchal

Authors
  1. Yolande Asara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Melis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laura Maria De Luca
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Corrado Bozzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paolo Castiglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giannina Chessa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Patrizia Piras
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Apostolos Karligkiotis
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Pasquale Bandiera
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Michele Malaguarnera
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Juan Antonio Marchal
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Roberto Madeddu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roberto Madeddu.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Additional information

Responsible editor: Philippe Garrigues

Yolande Asara and Andrea Melis contributed equally to the paper.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Asara, Y., Melis, A., De Luca, L.M. et al. Influence of metals on rhinosinusal polyposis in Sardinian population (Italy). Environ Sci Pollut Res 23, 21726–21732 (2016). https://doi.org/10.1007/s11356-016-7406-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-016-7406-6

Keywords

Search

Navigation