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The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity

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Abstract

25 phenolic acids, including four new isolates, eurylophenosides A–D (1–4) and 21 known ones (5–25) were isolated and identified from the stems of Oplopanax elatus Nakai. Among the known compounds 5–9, 11–13, 16, 18–25 were isolated from the genus for the first time; 17 was first obtained from the plant; and the NMR data of 22 was reported here first. Meanwhile, the UVB-induced photodamage model of HaCaT cells was used to study the prevent-photodamage abilities of compounds 1–2, 4–8, 11–13 and 15–25 with a nontoxic concentration at 50 μM. Moreover, a dose-dependent experiment was conducted for active compounds at the concentration of 10, 25, and 50 µM, respectively. Consequently, pretreatment with compounds 1, 16, 17, 19, 20, 22, 24 and 25 could suppress the cell viability decreasing induced by UVB irradiation in a concentration-dependent manner. These results indicated that phenolic acids were one kind of material basis with prevent-photodamage activity of O. elatus.

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Acknowledgements

This research was financially supported by Programs for National Natural Science Foundation of China (82074118), Important Drug Development Fund, Ministry of Science and Technology of China (2018ZX09735002).

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Author notes

  1. Yu Han and Dongsheng Cheng contributed equally to this work.

Authors and Affiliations

  1. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China

    Yu Han, Mimi Hao, Jiejing Yan, Yi Zhang & Tao Wang

  2. Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China

    Yu Han, Jingya Ruan, Lifeng Han, Yi Zhang & Tao Wang

  3. Yantai Yuhuangding Hospital, 20 Yuhuangding East Road, Zhifu District, Yantai, 264000, Shandong, China

    Dongsheng Cheng

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  1. Yu Han
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Han, Y., Cheng, D., Hao, M. et al. The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity. J Nat Med 76, 39–48 (2022). https://doi.org/10.1007/s11418-021-01546-6

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  • DOI: https://doi.org/10.1007/s11418-021-01546-6

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