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Physical and lifestyle factors associated with trabecular bone score values

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Abstract

Summary

TBS is associated with age, weight, childhood physical activity, and BMD in men and age, height, BMD, and mobility in women.

Introduction

Trabecular bone score (TBS) indirectly assesses trabecular microarchitecture at the lumbar spine, providing complementary information to areal BMD. Many studies have investigated the relationships between BMD and lifestyle factors known to affect bone, but such research is limited for TBS. The aim of this study was to assess the relationship between TBS and lifestyle factors in Australian men and women.

Methods

This cross-sectional study involved 894 men and 682 women (ages 24–98 years) enrolled in the Geelong Osteoporosis Study. TBS was assessed by analysis of lumbar spine DXA scans (Lunar Prodigy) using TBS iNsight software (Version 2.2). Bivariate and multivariable linear regression models were used to explore the associations between TBS and physical and lifestyle factors, including anthropometry, alcohol consumption, childhood physical activity, mobility, smoking status, prior low trauma fracture, medication use, and intakes of calcium and vitamin D.

Results

In bivariate regression modelling, low mobility and the use of antiresorptive medication were associated with lower TBS in both men and women. Low childhood physical activity was also associated with lower TBS in men. Prior fracture, use of glucocorticosteroids, and total calcium intake were also associated with lower TBS in women. The final adjusted model for men included age, weight, childhood physical activity, and BMD, and for women, age, height, BMD, and mobility. No interaction terms were identified in the models.

Conclusions

Lower TBS is associated with older age, increased weight, low childhood physical activity, and lower BMD in men and older age, shorter stature, lower BMD, and low mobility in women.

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Acknowledgements

The study is supported by the National Health and Medical Research Council (NHMRC) of Australia (251638, 299831, 628582), the Geelong Regional Medical Foundation, Arthritis Foundation of Australia, and Perpetual Trustees. NKH is supported by a Dean’s Research Postdoctoral Fellowship. KBA is supported by an Australian Research Training Program Scholarship. KLH-K is supported by an Alfred Deakin Postdoctoral Research Fellowship. The authors thank Professor Graham Giles of the Cancer Epidemiology Centre of The Cancer Council Victoria, for permission to use the Dietary Questionnaire for Epidemiological Studies (Version 2), Melbourne: The Cancer Council Victoria 1996.

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Authors and Affiliations

  1. IMPACT Institute, Deakin University, Geelong, Australia

    Kara B. Anderson, Kara L. Holloway-Kew, Mark A. Kotowicz, Natalie K. Hyde & Julie A. Pasco

  2. Center of Bone Diseases, Bone & Joint Department, Lausanne University Hospital, Lausanne, Switzerland

    Didier Hans

  3. Barwon Health, Geelong, Australia

    Mark A. Kotowicz & Julie A. Pasco

  4. Department of Medicine, Melbourne Medical School – Western Campus, The University of Melbourne, St Albans, Australia

    Mark A. Kotowicz & Julie A. Pasco

  5. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

    Julie A. Pasco

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  1. Kara B. Anderson
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Correspondence to Kara B. Anderson.

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Conflict of interest

DH is co-owner of the TBS patent and has corresponding ownerships shares and position at Medimaps group. KBA, KLH-K, MAK, NKH, and JAP have no conflict of interest.

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Anderson, K.B., Holloway-Kew, K.L., Hans, D. et al. Physical and lifestyle factors associated with trabecular bone score values. Arch Osteoporos 15, 177 (2020). https://doi.org/10.1007/s11657-020-00841-1

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