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Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder

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Abstract

The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Although neuroimaging studies, in general, and resting-state functional Magnetic Resonance Imaging (rs-fMRI), in particular, have provided relevant information regarding such alterations, rs-fMRI studies have been typically limited to the analysis of between-region functional connectivity alterations at low-frequency signal fluctuations (i.e., <0.08 Hz). Conversely, the local attributes of Blood Oxygen Level Dependent (BOLD) signal across different frequency bands have been seldom studied, although they may provide valuable information. Here, we evaluated local alterations in low-frequency fluctuations across different oscillation bands in OCD. Sixty-five OCD patients and 50 healthy controls underwent an rs-fMRI assessment. Alterations in the fractional amplitude of low-frequency fluctuations (fALFF) were evaluated, voxel-wise, across four different bands (from 0.01 Hz to 0.25 Hz). OCD patients showed decreased fALFF values in medial orbitofrontal regions and increased fALFF values in the dorsal-medial prefrontal cortex (DMPFC) at frequency bands <0.08 Hz. This pattern was reversed at higher frequencies, where increased fALFF values also appeared in medial temporal lobe structures and medial thalamus. Clinical variables (i.e., symptom-specific severities) were associated with fALFF values across the different frequency bands. Our findings provide novel evidence about the nature and regional distribution of functional alterations in OCD, which should contribute to refine neurobiological models of the disorder. We suggest that the evaluation of the local attributes of BOLD signal across different frequency bands may be a sensitive approach to further characterize brain functional alterations in psychiatric disorders.

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Acknowledgments

This study was supported by the Carlos III Health Institute (PI09/01331, PI10/01753, PI10/01003, CP10/00604, PI13/01958, and CIBER-CB06/03/0034), FEDER funds (“a way to build Europe”), and the Agency for Administration of University and Research (AGAUR, Barcelona; 2014SGR1672). Dr. Soriano-Mas is funded by a “Miguel Servet” contract (CP10/00604), Dr. Real by a “Juan Rodés” contract (J14/00038) and Dr. Subirà by a “Rio Hortega” contract (CM15/00189) from the Carlos III Health Institute. Mr. Guinea-Izquierdo is supported by a Ministry of Education, Culture and Sport grant (FPU014/04822). Dr. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (Grant # 1025619) and a NHMRC Clinical Career Development Fellowship (Grant # 628509). Dr. Sato is supported by Sao Paulo Research Foundation – Brazil (FAPESP Grant # 2013/10498-6); Dr. Hoexter is supported by Sao Paulo Research Foundation – Brazil (FAPESP Grant # 2013/16864-4).

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Authors and Affiliations

  1. Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Feixa Llarga s/n, 08907, L’Hospitalet de Llobregat, Barcelona, Spain

    Mònica Giménez, Andrés Guinea-Izquierdo, Ignacio Martínez-Zalacaín, Cinto Segalàs, Marta Subirà, Eva Real, Pino Alonso, José Manuel Menchón & Carles Soriano-Mas

  2. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Barcelona, Spain

    Mònica Giménez, Andrés Guinea-Izquierdo, Cinto Segalàs, Marta Subirà, Eva Real, Jesús Pujol, Josep Maria Haro, Pino Alonso, José Manuel Menchón & Carles Soriano-Mas

  3. Research Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, University of Barcelona, 08950, Sant Boi de Llobregat, Barcelona, Spain

    Victoria Villalta-Gil & Josep Maria Haro

  4. Affective Neuroscience Laboratory, Department of Psychology, Vanderbilt University, Nashville, TN, 37240, USA

    Victoria Villalta-Gil

  5. Department of Clinical Sciences, School of Medicine, University of Barcelona, 08907, Barcelona, Spain

    Andrés Guinea-Izquierdo, Marta Subirà, Pino Alonso & José Manuel Menchón

  6. MRI Research Unit, Department of Radiology, Hospital del Mar, 08003, Barcelona, Spain

    Jesús Pujol

  7. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, 3010, Australia

    Ben J Harrison

  8. Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, 5001, Brazil

    Joao R Sato

  9. Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, 05403-903, Brazil

    Marcelo Q Hoexter

  10. Depression and Anxiety Program, Department of Mental Health, Parc Taulí Sabadell, Hospital Universitari, 08208, Sabadell, Barcelona, Spain

    Narcís Cardoner

  11. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, 08193, Cerdanyola, Barcelona, Spain

    Narcís Cardoner

  12. Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, 08193, Cerdanyola, Barcelona, Spain

    Carles Soriano-Mas

Authors
  1. Mònica Giménez
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  2. Andrés Guinea-Izquierdo
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  3. Victoria Villalta-Gil
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  4. Ignacio Martínez-Zalacaín
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  5. Cinto Segalàs
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  6. Marta Subirà
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  7. Eva Real
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  8. Jesús Pujol
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  9. Ben J Harrison
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  10. Josep Maria Haro
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  11. Joao R Sato
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  12. Marcelo Q Hoexter
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  13. Narcís Cardoner
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  14. Pino Alonso
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  15. José Manuel Menchón
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  16. Carles Soriano-Mas
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Corresponding author

Correspondence to Carles Soriano-Mas.

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Conflicts of interest

All the authors declare that they have no conflicts of interest.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national: Institutional Review Board of Bellvitge University Hospital) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

Additional information

Mònica Giménez and Andrés Guinea-Izquierdo contributed equally to the work

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Giménez, M., Guinea-Izquierdo, A., Villalta-Gil, V. et al. Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder. Brain Imaging and Behavior 11, 1690–1706 (2017). https://doi.org/10.1007/s11682-016-9601-y

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  • DOI: https://doi.org/10.1007/s11682-016-9601-y

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