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Can Helicobacter pylori Eradication Treatment Modify the Metabolic Response to Bariatric Surgery?

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Abstract

Background

Helicobacter pylori (HP) colonization is common in severely obese patients undergoing bariatric surgery. HP eradication treatment could influence the evolution of weight loss and metabolic markers after bariatric surgery.

Objective

To assess the influence of HP eradication in the clinical course of morbid obesity patients treated with bariatric surgery (gastric bypass (LRYGB) and sleeve gastrectomy (LSG))

Methods

Retrospective analysis of a prospective cohort of 229 patients that underwent bariatric surgery between 2010 and 2013 in Hospital del Mar. HP infection was tested preoperatively by gastric biopsy and, if positive, treated with omeprazole, clarithromycin, and amoxicillin for 14 days. Patients were followed at 3, 6, 12, 18, and 24 months after bariatric surgery. Short-term weight loss and metabolic outcomes were evaluated.

Results

HP treated (HPt) patients had a greater reduction in BMI at 3 months after LSG (ΔBMI (kg/cm2) 8.5 ± 4.1 vs 11.3 ± 3.05 kg/m2; p = 0.004) and a reduction in the evolution of triglyceride levels from baseline to 12 months (p = 0.014) compared to HP-negative (HP−) subjects. Also, non-diabetic HPt patients had a greater reduction in glucose levels at all time points that was maintained up to 24 months after LRYGB (p = 0.003). No differences were observed in total and LDL cholesterol levels, HOMA-IR, or HbA1C.

Conclusions

Preoperative HP eradication has a short-term influence on some metabolic parameters after bariatric surgery.

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Acknowledgments

Dr. Fernando Burdio, Dr. Miguel Angel Checa, and Dr. Isaac Subirana are acknowledged for their supervision.

Funding

OCN is supported by a JR14/00008 and JR17/00022 from ISCIII. CIBEROBN is an ISCIII initiative.

Author information

Author notes

  1. Alberto Goday and Olga Castañer contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology and Nutrition, Hospital del Mar Research Institute, Passeig Marítim 25-29, 08003, Barcelona, Spain

    Alberto Goday, Olga Castañer, David Benaiges & Juana A. Flores Le-Roux

  2. Cardiovascular Risk and Nutrition Research Group (CARIN-ULEC), IMIM-Hospital del Mar Research Institute, Biomedical Research Park (Parc de Recerca Biomèdica de Barcelona – PRBB), Barcelona, Spain

    Alberto Goday, Olga Castañer & David Benaiges

  3. Department of Medicine, University Autònoma de Barcelona-Universitat Pompeu Fabra, Barcelona, Spain

    Alberto Goday, David Benaiges, Anna Busquets Pou, Maria del Mar Iglesias & Juana A. Flores Le-Roux

  4. Centro de Investigaciones Biomédicas en Red de Obesidad y Nutrición, CIBERobn, Barcelona, Spain

    Alberto Goday & Olga Castañer

  5. Unit of Gastrointestinal Surgery, Hospital del Mar, Hospital del Mar Research Institute, Barcelona, Spain

    José M. Ramón

  6. Pathology Unit, Hospital del Mar, Hospital del Mar Research Institute, Barcelona, Spain

    Maria del Mar Iglesias

  7. Department of Gastroenterology, Hospital del Mar Research Institute, Barcelona, Spain

    Luis Barranco Priego

Authors
  1. Alberto Goday
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  2. Olga Castañer
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  3. David Benaiges
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  5. José M. Ramón
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  6. Maria del Mar Iglesias
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Corresponding author

Correspondence to Olga Castañer.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Goday, A., Castañer, O., Benaiges, D. et al. Can Helicobacter pylori Eradication Treatment Modify the Metabolic Response to Bariatric Surgery?. OBES SURG 28, 2386–2395 (2018). https://doi.org/10.1007/s11695-018-3170-7

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  • DOI: https://doi.org/10.1007/s11695-018-3170-7

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