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Relationship Between Bariatric Surgery and Gastroesophageal Reflux Disease: a Systematic Review and Meta-analysis

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Abstract

The purpose of this study was to investigate the relationship between bariatric surgery (laparoscopic sleeve gastrectomy [LSG] and laparoscopic Roux-en-Y gastric bypass [LRYGB]) and gastroesophageal reflux disease (GERD). The number of obese patients with newly onset, worsened, or improved GERD after bariatric surgery in each article were extracted. In the pooled analysis, LSG was associated with a higher risk of GERD than LRYGB (odds ratio [OR] = 5.10, 95% confidence interval [CI] 3.60–7.23, p < 0.001). Compared with LSG, LRYGB had a better effect on GERD (OR = 0.19, 95% CI 0.12–0.30, p < 0.001). LRYGB was more effective for treating GERD in obese patients than LSG and the incidence of newly onset GERD after LRYGB was lower.

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Authors and Affiliations

  1. Department of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China

    Lihu Gu & Feiyan Mao

  2. Emergency Medical Center, Ninbo Yinzhou No 2 Hospital, Ningbo, Zhejiang, China

    Bangsheng Chen

  3. The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

    Nannan Du & Xiaojing Huang

  4. The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

    Rongrong Fu

  5. Monash University School of Medicine, Nursing and Health Sciences, Melbourne, Australia

    Parikshit Asutosh Khadaroo

  6. Department of General Surgery, Ningbo Yinzhou No 2 Hospital, 998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China

    Shenbiao Zhao

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  1. Lihu Gu
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Supplementary Table 1

Quality assessment of studies included. (DOCX 21 kb)

Supplementary Figure 1

Sensitivity analyses of the studies for newly onset or worsened GERD. GERD, gastroesophageal reflux disease (PNG 183 kb)

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Gu, L., Chen, B., Du, N. et al. Relationship Between Bariatric Surgery and Gastroesophageal Reflux Disease: a Systematic Review and Meta-analysis. OBES SURG 29, 4105–4113 (2019). https://doi.org/10.1007/s11695-019-04218-3

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