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Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing

  • HIV Pathogenesis and Treatment (AL Landay, Section Editor)
  • Published:
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Abstract

Increased life expectancy due to improved efficacy of cART has uncovered an increased risk of age-related morbidities in HIV+ individuals and catalyzed significant research into mechanisms driving these diseases. HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-AIDS malignancies, osteoporosis, and frailty. These observations suggest that HIV accelerates immunological ageing, and there are many immunological similarities with the aged, including shortened telomeres, accumulation of senescent T cells and altered monocyte phenotype/function. However, the most critical similarity between HIV+ individuals and the elderly, which most likely underpins the heightened risk of non-communicable diseases, is chronic inflammation and associated immune activation. Here, we review the similarities between HIV+ individuals and the aged regarding the pathogenesis of inflammatory diseases, the current evidence for mechanisms driving these processes and discuss current and potential therapeutic strategies for addressing inflammatory co-morbidity in HIV+ infection.

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Anna C. Hearps, Genevieve E. Martin, Reena Rajasuriar, and Suzanne M. Crowe declare that they have no conflict of interest

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  1. Centre for Biomedical Research, Burnet Institute, GPO Box 2248, Melbourne, VIC, 3001, Australia

    Anna C. Hearps, Genevieve E. Martin & Suzanne M. Crowe

  2. Department of Infectious Diseases, Monash University, Melbourne, Australia

    Anna C. Hearps & Suzanne M. Crowe

  3. Centre of Excellence for Research in AIDS and Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia

    Reena Rajasuriar

  4. Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia

    Suzanne M. Crowe

  5. Centre of Excellence for Research in AIDS (CERiA), Infectious Diseases Unit, Level 2, Menara Timur, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia

    Reena Rajasuriar

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Hearps, A.C., Martin, G.E., Rajasuriar, R. et al. Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing. Curr HIV/AIDS Rep 11, 20–34 (2014). https://doi.org/10.1007/s11904-013-0190-8

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