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Comprehensive Review of Topical Analgesics for Chronic Pain

  • Chronic Pain Medicine (O Viswanath, Section Editor)
  • Published:
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Abstract

Purpose of Review

Topical analgesics are a non-opioid option for the treatment of chronic pain conditions including neuropathic pain, musculoskeletal pain, and osteoarthritis. There are many topical medications available; however their efficacy is variable. This article reviews the various topical analgesics, their mechanisms of action, and their efficacy.

Recent Findings

Studies have found topical NSAIDs are useful in treating acute musculoskeletal pain syndromes (strains and sprains) and show some efficacy in treating hand and knee osteoarthritis (Derry et al. Cochrane Database Syst Rev 5:CD008609, 2017). Topical capsaicin 8% has been shown to be efficacious in the treatment of postherpetic neuralgia, painful diabetic peripheral neuropathy, and HIV-neuropathy (Derry et al. Cochrane Database Syst Rev 1:CD007393, 2017). Topical lidocaine has been widely studied and found to reduce pain in patients with postherpetic neuralgia (Knezevic et al. Pain Manag 7:537–58, 2017). Although many other topical analgesics are available, there is limited data to support the efficacy of other agents.

Summary

Topical analgesics are a relatively benign treatment for chronic pain conditions including neuropathic pain, musculoskeletal, and myofascial pain. There is evidence to support the use of topical NSAIDs, high concentration topical capsaicin, and topical lidocaine for various painful conditions.

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  1. Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic of Arizona, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA

    Jillian Maloney, Scott Pew, Christopher Wie, Ruchir Gupta, John Freeman & Natalie Strand

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Maloney, J., Pew, S., Wie, C. et al. Comprehensive Review of Topical Analgesics for Chronic Pain. Curr Pain Headache Rep 25, 7 (2021). https://doi.org/10.1007/s11916-020-00923-2

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