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Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus

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The objective of this study was to investigate the effects of different forms of Se supplementation on the antioxidant defense and glucose homeostasis in experimental diabetes. Sodium selenate (SS) or selenomethionine (SM) were administered (2 μmol Se kg−1 day−1) via orogastric route to streptozotocine (STZ)-induced diabetic rats in addition to basal diet for 12 weeks. Glucose levels in whole blood, glutathione peroxidase (GSH-Px) activity in erythrocytes, Se and fructosamine levels in plasma were evaluated monthly. Plasma Se levels increased significantly in all diabetic groups compared to basal measurements, being more prominent in SM group [p(SM3/SM0) = 0.018]. The increase in GSH-Px activities was significant at the end of the second month in SS [p(SS2/SS0) = 0.028], whereas at the end of the third month in SM the value was lower [p(SM3/SM0) = 0.018] and the unsupplemented diabetic control (DC) groups, p(DC3/DC0) = 0.012. Glucose increased significantly only in DC group. Fructosamine increased gradually in all diabetic groups, being significant in DC and SS groups. At the end of the third month, highest fructosamine levels were observed in SS group, which were significantly higher than the SM group [p(SM/SS) = 0.010]. In conclusion, Se augmented the antioxidant defense by increasing GSH-Px activity and this effect was more prominent when Se was supplemented as SM, which exerted positive effects also on glucose homeostasis.

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Authors and Affiliations

  1. Department of Biochemistry, School of Medicine, Dokuz Eylül University, Izmir, Turkey

    Zubeyde Erbayraktar & Canan Coker

  2. Animal Research Center, School of Medicine, Dokuz Eylül University, Izmir, Turkey

    Osman Yılmaz

  3. Medical and Molecular Biology, Fachhochschule, Aachen, Germany

    Ayşegul Temiz Artmann

  4. Institute of Oncology, Dokuz Eylül University, Izmir, Turkey

    Ruksan Cehreli

  5. Limanreis Mah. Basak Sok., Ulkem Sitesi, 87/B1 Narlidere, 35321, Izmir, Turkey

    Zubeyde Erbayraktar

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  1. Zubeyde Erbayraktar
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  2. Osman Yılmaz
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  4. Ruksan Cehreli
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  5. Canan Coker
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Correspondence to Zubeyde Erbayraktar.

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Erbayraktar, Z., Yılmaz, O., Artmann, A. et al. Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus. Biol Trace Elem Res 118, 217–226 (2007). https://doi.org/10.1007/s12011-007-0037-5

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  • DOI: https://doi.org/10.1007/s12011-007-0037-5

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