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Alterations in Biochemical Parameters During Subacute Toxicity of Fluoride Alone and in Conjunction with Aluminum Sulfate in Goats

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Abstract

Fluoride toxicity is a serious health problem in many parts of the globe. In present study, sodium fluoride at 20 mg/kg alone and in conjunction with aluminum sulfate at 150 mg/kg was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the alterations in the various biochemical parameters during subacute toxicity of fluoride alone and in conjunction with aluminum sulfate. In Group 1, significant alterations in plasma glucose, blood urea nitrogen (BUN), creatinine, total protein, albumin, globulin, albumin/globulin ratio, magnesium, and sodium were observed on different days of exposure from their pre-exposure values. However, no significant changes were observed in plasma calcium, phosphorus, and potassium on different days of exposure of sodium fluoride. Similar type of biochemical alterations were noticed in the goats of Group 2 except BUN, total protein magnesium, and sodium. On the basis of results, it could be concluded that sodium fluoride alone and in conjunction with aluminum sulfate produced significant alterations in the various biochemical parameters of the body.

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Acknowledgement

The authors are thankful to Vice Chancellor, Sher-e-Kashmir University of Agriculture Sciences and Technology, Jammu for providing necessary facilities.

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Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-J, R.S. Pura, Jammu, 181102, J&K, India

    Vinay Kant

  2. National Dairy Research Institute, Karnal, India

    Anil Kumar Srivastava

  3. Division of Pharmacology and Toxicology, SKUAST-J, R.S. Pura, Jammu, India

    Pawan Kumar Verma & Rajinder Raina

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  1. Vinay Kant
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  2. Anil Kumar Srivastava
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  3. Pawan Kumar Verma
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  4. Rajinder Raina
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Correspondence to Vinay Kant.

Additional information

Part of M.V.Sc. research conducted in Division of Pharmacology and Toxicology, F.V.Sc. and A.H., SKUAST-J, R.S. Pura, Jammu-181102, J&K, INDIA.

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Kant, V., Srivastava, A.K., Verma, P.K. et al. Alterations in Biochemical Parameters During Subacute Toxicity of Fluoride Alone and in Conjunction with Aluminum Sulfate in Goats. Biol Trace Elem Res 130, 20–30 (2009). https://doi.org/10.1007/s12011-008-8311-8

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