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Alterations in Electrocardiographic Parameters after Subacute Exposure of Fluoride and Ameliorative Action of Aluminium Sulphate in Goats

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Abstract

Fluorosis or crippling disease is one of the existing environmental challenges for animal and human beings in most parts of the globe. In the present study, sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the effect on the electrocardiogram. All waves of Lead I, Lead II, Lead III, aVR, aVL and aVF in electrocardiographs were recorded before and after 30 days exposure of fluoride. A significant (P < 0.05) increase in P–R, Q–T and S–T intervals were observed in goats of group 1 as compared to their pre treatment values. The T wave duration was also significantly (P < 0.05) prolonged and as a result, bradycardia was observed after subacute exposure of fluoride for 30 days in group 1. But, in group 2, no such changes were observed. On the basis of results, it may be concluded that subacute toxicity of fluoride produces significant changes in different waves of electrocardiogram and aluminium sulphate has ameliorative efficacy.

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Acknowledgement

The authors are thankful to Vice Chancellor Sher-e-Kashmir University of Agriculture Sciences and Technology, Jammu for providing the necessary facilities.

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Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences & Animal Husbandry, SKUAST-J, R.S. Pura, Jammu, 181102, J&K, India

    Vinay Kant, Pawan Kumar Verma, Rajinder Raina & Nrip Kishore Pankaj

  2. National Dairy Research Institute, Karnal, India

    Anil Kumar Srivastava

Authors
  1. Vinay Kant
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  2. Anil Kumar Srivastava
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  3. Pawan Kumar Verma
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  4. Rajinder Raina
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  5. Nrip Kishore Pankaj
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Correspondence to Vinay Kant.

Additional information

This work is part of M.V.Sc. research conducted in Division of Pharmacology and Toxicology, F.V.Sc. & A.H., SKUAST-J, R.S. Pura, Jammu, 181102, J&K, INDIA.

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Kant, V., Srivastava, A.K., Verma, P.K. et al. Alterations in Electrocardiographic Parameters after Subacute Exposure of Fluoride and Ameliorative Action of Aluminium Sulphate in Goats. Biol Trace Elem Res 134, 188–194 (2010). https://doi.org/10.1007/s12011-009-8460-4

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  • DOI: https://doi.org/10.1007/s12011-009-8460-4

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