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The Allium triquetrum L. Leaves Mitigated Hepatotoxicity and Nephrotoxicity Induced by Lead Acetate in Wistar Rats

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Abstract

The aim of this study was to scrutinize the possible mitigating role of leaves’ Allium triquetrum L. against the toxicity of lead acetate on liver and kidney markers of Wistar rat. Lead acetate (Pb) and leaves’ aqueous extracts (L) were orally administrated for 3 weeks. Rats were divided into the control, Pb group (500 mg/kg body weight/day), positive controls L (2g, 3g, 4g/kg BW/day), along with three combined groups of the same doses (Pb-L1, Pb-L2, Pb-L3). The levels of plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total proteins (TP), albumin (ALB), urea, creatinine (Cr), and uric acid (UA), as well as the hepatic and the renal malondialdehyde (MDA), glutathione (GSH), and glutathione peroxidase (GPx), were estimated. Results exhibited a significant increase in plasma AST, ALT, ALP, urea, creatinine, uric acid, and MDA levels of the Pb group compared to the control, with the exception of TP, ALB, GSH levels, and GPx activities that were significantly diminished, though the co-administration of garlic extracts (Pb-L) revealed a significant decrease in all mentioned markers, excluding the TP, ALB, GSH, and GPx levels. Likewise, Pb caused histological injuries in the hepatic and renal tissues of rats, while the co-administration of leaves’ wild garlic has reduced such effect. Thought, the Pb-L has attenuated the Pb-induced toxicity in a dose-dependent manner. In conclusion, the aqueous extracts of A. triquetrum have the potential to alleviate Pb hepatotoxicity and nephrotoxicity through the modulation of most biomarkers in Wistar rat.

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Acknowledgements

The authors would like to thank the General Directorate of Scientific Research and Technological Development (DGRSDT) for supporting this project (award number 04/2016).

Funding

The authors received financial support for bench fees, but not for authorship, and/or for publication of this article.

The datasets generated during the current study are available from the corresponding author on reasonable request.

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  1. Laboratory of Animal Ecophysiology, Department of Biology, Faculty of Sciences, University Badji Mokhtar-Annaba, 23000, Annaba, Algeria

    Labiba Kahalerras, Ines Otmani & Cherif Abdennour

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  1. Labiba Kahalerras
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  2. Ines Otmani
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  3. Cherif Abdennour
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L Kahalerras drafted the manuscript and contributed to the analysis and interpretation of results; I Otmani participated in the experimental work; C Abdennour corrected and revised the manuscript. All authors read and gave the final approval of the manuscript.

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Correspondence to Labiba Kahalerras.

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Kahalerras, L., Otmani, I. & Abdennour, C. The Allium triquetrum L. Leaves Mitigated Hepatotoxicity and Nephrotoxicity Induced by Lead Acetate in Wistar Rats. Biol Trace Elem Res 200, 4733–4743 (2022). https://doi.org/10.1007/s12011-021-03052-y

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