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hESC Adaptation, Selection and Stability

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References

  1. Aladjem, M. I., Spike, B. T., Rodewald, L. W., Hope, T. J., Klemm, M., Jaenisch, R., et al. (1998). ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Current Biology, 8, 145–155.

    Article  PubMed  CAS  Google Scholar 

  2. Amit, M., Carpenter, M. K., Inokuma, M. S., Chiu, C. P., Harris, C. P., Waknitz, M. A., et al. (2000). Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Developments in Biologicals, 227, 271–278.

    CAS  Google Scholar 

  3. Baker, D. E., Harrison, N. J., Maltby, E., Smith, K., Moore, H. D., Shaw, P. J., et al. (2007) Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nature Biotechnology, 25, 207–215.

    Article  PubMed  CAS  Google Scholar 

  4. Bhattacharya, B., Cai, J., Luo, Y., Miura, T., Mejido, J., Brimble, S. N., et al. (2005). Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies. BMC Developmental Biology, 5, 22.

    Article  PubMed  CAS  Google Scholar 

  5. Brimble S. N., Zeng, X., Weiler, D. A., Luo, Y., Liu, Y., Lyons, I. G., et al. (2004). Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9 2001. Stem Cells Development 13, 585–597.

    Article  CAS  Google Scholar 

  6. Buzzard, J. J., Gough, N. M., Crook, J. M., Colman, A. (2004) Karyotype of human ES cells during extended culture. Nature Biotechnology, 22, 381-382

    Article  PubMed  CAS  Google Scholar 

  7. Chao, C., Saito, S., Kang, J., Anderson, C. W., Appella, E., & Xu, Y. (2000). p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO Journal, 19, 4967–4975.

    Article  PubMed  CAS  Google Scholar 

  8. Draper, J. S., Smith, K., Gokhale, P., Moore, H. D., Maltby, E., Johnson, J., et al. (2004) Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nature Biotechnology, 22, 53–54.

    Article  PubMed  CAS  Google Scholar 

  9. Enver, T., Soneji, S., Joshi, C., Brown, J., Iborra, F., Orntoft, T., et al. (2005) Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Human Molecular Genetics, 14, 3129–3140.

    Article  PubMed  CAS  Google Scholar 

  10. Ginis, I., Luo, Y., Miura, T., Thies, S., Brandenberger, R., Gerecht-Nir, S., et al. (2004). Differences between human and mouse embryonic stem cells. Developments in Biologicals, 269, 360–380.

    Article  CAS  Google Scholar 

  11. Hardy, K., Handyside, A. H., & Winston, R. M. (1989). The human blastocyst: Cell number, death and allocation during late preimplantation development in vitro. Development, 107, 597–604.

    PubMed  CAS  Google Scholar 

  12. Herszfeld, D., Wolvetang, E., Langton-Bunker, E., Chung, T. L., Filipczyk, A. A., Houssami, S., et al. (2006). CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nature Biotechnology, 24, 351–357.

    Article  PubMed  CAS  Google Scholar 

  13. Hoffman, L. M., & Carpenter, M. K. (2005). Characterization and culture of human embryonic stem cells. Nature Biotechnology, 23, 699–708.

    Article  PubMed  CAS  Google Scholar 

  14. Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991). p53 mutations in human cancers. Science, 253, 49–53.

    Article  PubMed  CAS  Google Scholar 

  15. Holm, T. M., Jackson-Grusby, L., Brambrink, T., Yamada, Y., Rideout, W. M., 3rd, & Jaenisch, R. (2005). Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell, 8, 275.

    Article  PubMed  CAS  Google Scholar 

  16. Hong, Y., & Stambrook, P. J. (2004). Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proceedings of the National Academy of Sciences of the United States of America, 101, 14443–14448.

    Article  PubMed  CAS  Google Scholar 

  17. Hussain, S. P., & Harris, C. C. (1998). Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Research, 58, 4023–4037.

    PubMed  CAS  Google Scholar 

  18. Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., et al. (2005). Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes & Development, 19, 489–501.

    Article  CAS  Google Scholar 

  19. Laslett, A. L., Grimmond, S., Gardiner, B., Stamp, L., Lin, A., Hawes, S. M., et al. (2007). Transcriptional analysis of early lineage commitment in human embryonic stem cells. BMC Developmental Biology, 7(1), 12.

    Article  PubMed  CAS  Google Scholar 

  20. Levine, A. J. (1997). p53, the cellular gatekeeper for growth and division. Cell, 88, 323–331.

    Article  PubMed  CAS  Google Scholar 

  21. Maitra, A., Arking, D. E., Shivapurkar, N., Ikeda, M., Stastny, V., Kassauei, K., et al. (2005) Genomic alterations in cultured human embryonic stem cells. Nature Genetics, 37, 1099–1103.

    Article  PubMed  CAS  Google Scholar 

  22. Mastromonaco, G. F., Perrault, S. D., Betts, D. H., & King, W. A. (2006). Role of chromosome stability and telomere length in the production of viable cell lines for somatic cell nuclear transfer. BMC Developmental Biology, 6, 41.

    Article  PubMed  CAS  Google Scholar 

  23. Metcalfe, A. D., Hunter, H. R., Bloor, D. J., Lieberman, B. A., Picton, H. M., Leese, H. J., et al. (2004). Expression of 11 members of the BCL-2 family of apoptosis regulatory molecules during human preimplantation embryo development and fragmentation. Molecular Reproduction & Development, 68, 35–50.

    Article  CAS  Google Scholar 

  24. Mitalipova, M. M., Rao, R. R., Hoyer, D. M., Johnson, J. A., Meisner, L. F., Jones, K. L., et al. (2005) Preserving the genetic integrity of human embryonic stem cells. Nature Biotechnology, 23, 19–20.

    Article  PubMed  CAS  Google Scholar 

  25. Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S., & Hannon, G. J. (2005). Characterization of Dicer-deficient murine embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 102, 12135–12140.

    Article  PubMed  CAS  Google Scholar 

  26. Nonaka, M., Horie, R., Itoh, K., Watanabe, T., Yamamoto, N., & Yamaoka, S. (2005). Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene, 24(24), 3976–3986.

    Article  PubMed  CAS  Google Scholar 

  27. Qin, H., Yu, T., Qing, T., Liu, Y., Zhao, Y., Cai, J., et al. (2006). Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. Journal of Biological Chemistry, 282, 5842–5852.

    Article  PubMed  Google Scholar 

  28. Ramalho-Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002). “Stemness”: transcriptional profiling of embryonic and adult stem cells. Science, 298, 597–600.

    Article  PubMed  CAS  Google Scholar 

  29. Reubinoff, B. E., Pera, M. F., Fong, C. Y., Trounson, A., & Bongso, A. (2000). Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro [see comment][erratum appears in Nat Biotechnol 2000 May;18(5):559]. Nature Biotechnology, 18, 399–404.

    Article  PubMed  CAS  Google Scholar 

  30. Sabapathy, K., Klemm, M., Jaenisch, R., & Wagner, E. F. (1997). Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO Journal, 16, 6217–6229.

    Article  PubMed  CAS  Google Scholar 

  31. Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., et al. (1998). Embryonic stem cell lines derived from human blastocysts. Science, 282, 1145–1147.

    Article  PubMed  CAS  Google Scholar 

  32. Van Sloun, P. P., Jansen, J. G., Weeda, G., Mullenders, L. H., van Zeeland, A. A., Lohman, P. H., et al. (1999). The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage. Nucleic Acids Research, 27, 3276–3282.

    Article  PubMed  Google Scholar 

  33. Wang, Y., Medvid, R., Melton, C., Jaenisch, R., & Blelloch, R. (2007). DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nature Biotechnology, 39, 380–385.

    CAS  Google Scholar 

  34. Xu, C., Inokuma, M. S., Denham, J., Golds, K., Kundu, P., Gold, J. D., et al. (2001). Feeder-free growth of undifferentiated human embryonic stem cells. Nature Biotechnology, 19, 971–974.

    Article  PubMed  CAS  Google Scholar 

  35. Xu, D., Wilson, T. J., Chan, D., De Luca, E., Zhou, J., Hertzog, P. J., et al. (2002). Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO Journal, 21, 4081–4093.

    Article  PubMed  CAS  Google Scholar 

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Grandela, C., Wolvetang, E. hESC Adaptation, Selection and Stability. Stem Cell Rev 3, 183–191 (2007). https://doi.org/10.1007/s12015-007-0008-4

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