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Implication of Paraprobiotics in Age-Associated Gut Dysbiosis and Neurodegenerative Diseases

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Abstract

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are major age-related concerns in elderly people. Since no drug fully addresses the progression of neurodegenerative diseases, advance treatment strategies are urgently needed. Several studies have noted the senescence of immune system and the perturbation of gut microbiota in the aged population. In recent years, the role of gut microbiota has been increasingly studied in the manifestation of age-related CNS disorders. In this context, prebiotics, probiotics, and paraprobiotics are reported to improve the behavioural and neurobiological abnormalities in elderly patients. As live microbiota, prescribed in the form of probiotics, shows some adverse effects like sepsis, translocation, and horizontal gene transfer, paraprobiotics could be a possible alternative strategy in designing microbiome-based therapeutics. This review describes the health-beneficial effects of paraprobiotics in age-associated neurodegenerative diseases.

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Acknowledgements

The authors (ZR and MPD) want to thank the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India for financial support. NIPER

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  1. Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India

    Ziaur Rahman & Manoj P. Dandekar

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ZR gathered literature and drafted the manuscript; MPD conceptualized, reviewed, and corrected the draft.

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Rahman, Z., Dandekar, M.P. Implication of Paraprobiotics in Age-Associated Gut Dysbiosis and Neurodegenerative Diseases. Neuromol Med 25, 14–26 (2023). https://doi.org/10.1007/s12017-022-08722-1

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