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Maternal nutritional history modulates the hepatic IGF–IGFBP axis in adult male rat offspring

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Abstract

Alterations in early life nutrition lead to an increased risk of obesity and metabolic syndrome in offspring. We have shown that both relative maternal undernutrition (UN) and maternal obesity result in metabolic derangements in offspring, independent of the postnatal dietary environment. Since insulin-like growth factor binding protein 2 (IGFBP2) has been shown to be independently associated with obesity and diabetes risk, we examined the IGF–IGFBP axis in male rat offspring following either maternal UN or maternal obesity to explain possible common pathways in the development of metabolic disorders. Wistar rats were time-mated and fed either a control diet (CONT), 50 % of CONT (UN) or a high-fat (HF) diet throughout pregnancy. Male offspring were weaned onto a standard chow diet and blood and tissues were collected at postnatal day 160. Plasma and hepatic tissue samples were analysed for key players in the IGF–IGFBP system. Both maternal UN and HF resulted in increased fat mass, hyperinsulinemia, hyperleptinemia and altered blood lipid profiles in offspring compared to CONT. Circulating IGF-1 and IGFBP3 levels and hepatic mRNA expression of IGFBP1 and IGFBP2 were significantly decreased in UN and HF offspring compared to CONT. DNA methylation of the IGFBP2 promotor region was similar between maternal dietary groups. Although chaperone gene heat-shock protein 90 and hepatic IGFBP1 were significantly correlated in CONT offspring this effect was absent in both UN and HF offspring. In conclusion, this study is one of the first to directly compare two experimental models of developmental programming representing both ends of the maternal dietary spectrum. Our data suggest that two disparate nutritional models that elicit similar adverse metabolic phenotypes in offspring are characterised by common alterations in the IGF–IGFBP pathway.

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Acknowledgments

The authors thank Eric Thorstensen and Rachna Patel for performing the autoanalyser and ELISA assay analysis, respectively. We also acknowledge funding support from the Health Research Council of New Zealand and Gravida; the National Centre for Growth and Development, Auckland, New Zealand.

Conflict of interest

The authors report no competing interests.

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Authors and Affiliations

  1. Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland, New Zealand

    Timothy Smith, Deborah M. Sloboda & Mark H. Vickers

  2. Murdoch Childrens Research Institute, Melbourne, VIC, Australia

    Richard Saffery & Eric Joo

  3. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada

    Deborah M. Sloboda

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  1. Timothy Smith
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  2. Deborah M. Sloboda
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  3. Richard Saffery
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  4. Eric Joo
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  5. Mark H. Vickers
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Correspondence to Mark H. Vickers.

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Smith, T., Sloboda, D.M., Saffery, R. et al. Maternal nutritional history modulates the hepatic IGF–IGFBP axis in adult male rat offspring. Endocrine 46, 70–82 (2014). https://doi.org/10.1007/s12020-013-0034-8

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  • DOI: https://doi.org/10.1007/s12020-013-0034-8

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