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Thyroid Cancer Epidemiology in South Spain: a population-based time trend study

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Abstract

Purpose

Thyroid cancer (TC) is the most common malignant disease of the endocrine system. The aim of this study was to analyze incidence and mortality trends of TC (C73 according to ICD-O-3) in Granada (Southern Spain) during the period 1985–2013, by sex, age, and histological type.

Methods

This is a population-based cross-sectional study. Incidence data were obtained from the population-based Cancer Registry of Granada. All newly diagnosed cases of thyroid cancer over the period 1985–2013 were included. Joinpoint regression analysis with age-standardized rates were used to estimate annual percentage change (APC), CI 95% and turning points in trends. Results are presented by sex, age group, and histological type.

Results

During the study period there were 1265 diagnosed cases of TC in Granada (72.6% in women). Incidence trends significantly increased in both men (APC: + 5.4%) and women (APC: + 4.7%). The most common histological types in both sexes were papillary (74.8%) and follicular (16.8%). The incidence has increased during the study period mainly due to papillary carcinoma, which has increased annually around 6% in both sexes. TC mortality trend during this period decreased in men (APC: −0.3%) and women (APC: −2.3%).

Conclusion

Our data showed an increasing trend in incidence of thyroid cancer in Granada, especially in women between 55–64 years. Mortality showed a slight decrease trend during the study period in both sexes. Papillary carcinoma was the most common histological type, with an increase of the relative weight of papillary microcarcinomas. Our study is in accordance with the European and worldwide trends in thyroid cancer incidence and mortality and sex differences.

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Acknowledgements

We thank Granada Cancer Registry workers for their job collecting these data.

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Authors and Affiliations

  1. Andalusian School of Public Health (EASP), Granada, Spain

    Elena Salamanca-Fernández, Miguel Rodriguez-Barranco, Yoe-Ling Chang-Chan, Daniel Redondo-Sánchez & María José Sánchez

  2. CIBER Epidemiology and Public Health (CIBERESP), Granada, Spain

    Elena Salamanca-Fernández, Miguel Rodriguez-Barranco & María José Sánchez

  3. Biosanitary Investigation Institute ibs, Granada, Spain

    Elena Salamanca-Fernández, Miguel Rodriguez-Barranco, Yoe-Ling Chang-Chan, Daniel Redondo-Sánchez, José Expósito & María José Sánchez

  4. University Hospital Virgen de las Nieves Granada, Granada, Spain

    Santiago Domínguez-López

  5. Radiation Oncology Department, University Hospital Virgen Macarena, Sevilla, Spain

    Eloísa Bayo

  6. Preventive Medicine and Public Health Department, Hospital Virgen de la Victoria of Málaga, Málaga, Spain

    Dariusz Narankiewicz

  7. Radiotherapy and Oncology Department, University Hospital Virgen de las Nieves Granada, Granada, Spain

    José Expósito

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  1. Elena Salamanca-Fernández
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Correspondence to Miguel Rodriguez-Barranco.

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This article does not contain any studies with human participants or animals performed by any of the authors. This study is based on secondary administrative data.

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Salamanca-Fernández, E., Rodriguez-Barranco, M., Chang-Chan, YL. et al. Thyroid Cancer Epidemiology in South Spain: a population-based time trend study. Endocrine 62, 423–431 (2018). https://doi.org/10.1007/s12020-018-1681-6

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