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Primary Pituitary Lymphoma: A Histological, Immunohistochemical, and Ultrastructural Study with Literature Review

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Abstract

We report the case of a 62-year-old man with headache and left sixth cranial nerve palsy. A computerized tomography scan revealed an osteolytic process involving the sella turcica and clivus. A partial tumor resection was achieved via an endoscopic transsphenoidal approach. Morphologic investigation revealed a diffuse large B cell lymphoma involving pituitary parenchyma. No systemic disease was found upon staging. Primary pituitary lymphoma is extremely rare. An accurate histologic diagnosis is key to successful treatment and a favorable prognosis. The literature is reviewed.

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Acknowledgement

Authors are grateful to the Jarislowsky Foundation and Lloyd Carr-Harris Foundation for the support and Ms. Corine Holubowich for the literature search.

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Correspondence to Olga Moshkin.

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Moshkin, O., Muller, P., Scheithauer, B.W. et al. Primary Pituitary Lymphoma: A Histological, Immunohistochemical, and Ultrastructural Study with Literature Review. Endocr Pathol 20, 46–49 (2009). https://doi.org/10.1007/s12022-009-9062-6

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