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Purinoceptors on Neuroglia

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An Erratum to this article was published on 28 April 2009

Abstract

Purinergic transmission is one of the most ancient and widespread extracellular signalling systems. In the brain, purinergic signalling plays a unique role in integrating neuronal and glial cellular circuits, as virtually every type of glial cell possesses receptors to purines and pyrimidines. These receptors, represented by metabotropic P1 adenosine receptors, metabotropic P2Y purinoceptors and ionotropic P2X purinoceptors, control numerous physiological functions of glial cells and are intimately involved in virtually every form of neuropathology. In this essay, we provide an in depth overview of purinoceptor distribution in two types of CNS glia—in astrocytes and oligodendrocytes—and discuss their physiological and pathophysiological roles.

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Acknowledgements

GB thanks the Leverhulme Trust for their support. AV and OK acknowledge financial support from INTAS; AV research is also supported by Alzheimer Research Foundation (UK) and by the Grant Agency of the Czech Republic. The authors thank Dr. Gillian E. Knight for excellent editorial assistance.

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Authors and Affiliations

  1. School of Biological Sciences, The University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Alexei Verkhrasky

  2. Institute of Experimental Medicine, ASCR, Videnska 1083, Prague 4, 142 20, Czech Republic

    Alexei Verkhrasky

  3. Bogomoletz Institute of Physiology, Bogomoletz Str. 4, Kiev-24, Ukraine

    Oleg A. Krishtal

  4. Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK

    Geoffrey Burnstock

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  1. Alexei Verkhrasky
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  2. Oleg A. Krishtal
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  3. Geoffrey Burnstock
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Correspondence to Alexei Verkhrasky.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s12035-009-8070-3

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Verkhrasky, A., Krishtal, O.A. & Burnstock, G. Purinoceptors on Neuroglia. Mol Neurobiol 39, 190–208 (2009). https://doi.org/10.1007/s12035-009-8063-2

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  • DOI: https://doi.org/10.1007/s12035-009-8063-2

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